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Complete Pharmacology > Cancer Biologic Drugs > Flashcards

Cancer Biologic Drugs Flashcards

1
Q

Aside from Hypersensitivity and Increased LFTs, Name 2 Adverse effects of Cetuximab

A
  1. Acneiform Eruption (red paps in sebaceous areas)
  2. Hypomagnesia
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2
Q

Considering that B-RAF mutations commonly result in Melanoma, it makes sense to use a Vengeful drug such as _______.

A

Vemurafenib

“V for Vemura” (V for vendetta)

“Wrathful Vengenace= RAF-ful Vengange”

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3
Q

Key MOA Difference of 1. Nivolumab and 2. Atezolizumab

A
  1. Nivo targets T-cells’ PD-L1
  2. Atezo targets Tumors’ PDL-1
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4
Q

Name the two main PD-1 Binding Drugs

A
  1. Nivolumab
  2. Atezolizumab
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5
Q

Ironically, the Vengeful Vemurafenib’s main adverse effect is

A

OTHER SKIN CANCERS

(cutaneous squam or keratocanthomas)

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6
Q

Two main drugs to treat NSCLC. One is against EGF-R, the other inhibits ALK.

A
  1. Erlotinib
  2. Crizotinib
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7
Q

Crizotinib is used for NSCLC, but ONLY if there a mutation in ______ or ______, which makes sense because it inhibits both of these guys.

A
  • ALK
  • ROS 1
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8
Q

Rituximab 3 indications

A
  1. CLL
  2. Diffuse B-Cell Lymphoma
  3. Follicular Lymphoma
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9
Q

ATRA binds mutated Retinoic acid receptor to drive differentation of ____ cells

A

Promyelocytic

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10
Q

Rituximab MOA

A
  • Target CD20 on B cells
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11
Q

B-RAF is an ____ with activating mutations seen in melanoma and other cancers

A

Oncogene

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12
Q

Imatinib Reks Gastrointestinal Stromal Turmors (GIST) by binding ______.

A

C-Kit

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13
Q

ATRA stands for __________ and is used to teat Acute Promyelocytic Leukemia (APmL)

A

All-Trans Retinoic Acid “The APL contains Retinoic acid”

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14
Q

Main Tyrosine Kinase Inhibitor drug that treats CML and GIST?

A

Imatinib

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15
Q

Cetuixmab treat which 2 main thirsty cancers?

A
  • Colorectal
  • Head & Neck
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16
Q

If you take imatinib, you should avoid grapefruit, but CYP_____ metabolizes it

A

3A4

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17
Q

” V for Vemurafenib” treats Melanoma by inhibiting mutated _____,, specifically the V600E mutation

A

BRAF

“Wrathful Vengence”

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18
Q

Trastuzumab binds to _______ tyrosine kinase and prompts immune-mediated antibody-dependent cellular cytotoxicity.

“Trash-Tuzumab”

A

HER-2

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19
Q

You might think you’re in love with Trastuzumab, but it might be the ______ that occurs as its main side-effect

A

Cardiomyopathy

20
Q

Tumors can bind on ________ Receptors on T-Cells to shut them down.

A

PD-1

21
Q

What teratogenic drug treats both Multiple Myeloma and Non-Hodg Lymphoma?

A

Lenalidomide

22
Q

Imatinib smacks CML and by binding to the cataylitc cleft of _____ on the ______ Chimeric Fusion. This is great, because you don’t want it to be constituitvely active anymore.

A
  • ABL
  • BCR-ABL
23
Q

Lenalidomide treats both _____ and _____

A
  • MM
  • NHGL
24
Q

Blake Bortezomib 2 Adverse Side Effects

A
  1. Neuropathy ( QB stocking Glove)
  2. Myelosuppresion (WBC, RBC, Platelet)
25
Q

Nivolumab and Atezolizumab MOA to treat cancer

A

Block the T-cell Sleeper, PDL1

26
Q

Aside found wound healing probs, GI perforation, and Proteinuria, what 3 Adverse effects do you expect with Bloody Bevacizumab

A
  • Cardiac (HTN)
  • Arterial Thrombotic Events (TIA, Stroke, Etc.)
  • Pulm Hemorrhage
27
Q

Cetuximab and Erlotinib both target ______, but treat different diseases

A

EGF-R

28
Q

Aside from Lenalidomide, ______ is a proteosome inhibitor that can also tackle Multiple Myeloma as fast as a Jaguar.

A

Bortezomib

“Blake Bortles”

29
Q

Ready, ______ Goes the extra mile to tag Extracellular Epidermal Growth Factor’s Receptor (EGF-R) while drinking a glass of ______, which also targets (EGF-R).

[Name the 2 Drugs that target EGF-R]

A
  • Cetuximab

“Ready, SET-uximab Go”

  • Erlotinib

“Merlot-inib”

30
Q

Lenalidomide is thought to treat both MM & NHL by inhibiting the two immuno-products known as ______ and ______

A
  • TNF-Alpha
  • IL-10
31
Q

Main anti B-cell CD20 targeting drug is called _______

A

Rituximab

32
Q

Aside from Fatigue, rashes, and MSK probs, name 3 key adverse effects of the PDL-1 (tumor) inhibitor Atezolizumab

A
  1. Pneumonitis
  2. Colitis
  3. Hepatitis
33
Q

In regards to Nivolumab vs Atezolizumab, Atezo can only treat _____ carcinoma, whereas Nivo treats that and Hodgkin, Melanoma, NSCLC, Renal, and Head/Neck

A

Urothelial

34
Q

Aside from nausea, vomiting, diahrrhea, cough, and shortness of breath, what key Adverse Reaction will the EGF-R blocker Erlotinib have?

A

Aceniform Eruption

35
Q

To tackle solid tumors, the drug ______ is Anti-VEGF

A

Bevacizumab

36
Q

Key adverse effect of Lenalidomide?

A

Teratogenic!

37
Q

Long Mnemnoic for Crizotinib?

A

Crazy Alkaline Rose Tea

“Crizo, ALK, ROS-1”

38
Q

Bloody Bevacizumab’s MOA to treat Lung, Colon, and breast cancer

A

Anti-VEGF Receptor

39
Q

Blake Bortezomib inhibits that vicious Jaguar bite from ______ _____ to down-regulate over-active NFKB signaling.

A

26-S Proteasome

40
Q

Aside from avoiding Grapefruit because of CYP3A4, Name 3 Adverse Effects of Imatinib that you should worry about when treating Chronic Myeloid Leukemia (CML),

A
  • Edema (face hands feet)
  • Skin Rash
  • Pancytopenia
41
Q

Just like Cetuximab, _______ also tags against EGFR-R, and also causes that Acneiform Eruption.

A

Erlotinib

“Glass of Erlot-tinib”

42
Q

ATRA is used to treat ____ ____ ____

A

Acute Promyelocytic Leukemia

43
Q

2 Mutations that decrease Cetuximab’s Response

A
  1. K-RAS
  2. BRAF
44
Q

Main drug used to bind HER-2?

(I swear it’s not Garbage, it’s actually pretty good against Breast cancer and GI Cancer.)

A

Trastuzumab

“Trash-Tuzumab”

45
Q

3 Adverse effects from ATRA when treating acute promyelocytic leuk? (Note: This can be reversed via Steroids and Chemo)

A
  • Leukocytosis (especially neutros)
  • Capillary Leak Syndrome (pulm edema)
  • Renal Failure
46
Q

What’s the Craziest Inhibitor of (ALK) Activin Receptor=lke Kinase/ other tyrosine kinase that treats NSCLC?

A

Crizotinib

“Crazy-tinib”

Complete Pharmacology (25 decks)

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