Antidepressants

Question 1

TCAs target both NE and 5-HT, so you see a lot of side effects. Name 4 different side-effects

Answer 1

1. Alpha-block (orthostatic hypotension)
2. Anticholinergics
3. Weight Gain
4. Arrhythmias and Seizures with OD

Question 2

Phenelzine and Tranylcypromine are both _______

Answer 2

MAOIs

Question 3

Why is Trazodone preferred over Nefazodone, even though they both antagonize 5-HT2 receptors?

Answer 3

Nefazodone has Black box warning due to hepatotoxicity

Question 4

Name the 2 SNRIs

Answer 4

1. Venlafaxine

2. Duloxetine

Question 5

SNRI or SSRIs mixed with MAOIs or dextrometh, sumatriptan, tramadol, or st john’s wort can all lead to _____ ______

Answer 5

Serotonin Syndrome

Question 6

Aside from Nausea, headache, anxiety, agitation, insomnia, and sexual dysfunction, name 3 SSRI side-effects

Answer 6

1. Extrapyramidal Effects
2. Seizures with Gross Overdose
3. Serotonin Syndrome with MAOI

Question 7

Bupropion and Mirtazapine are both ______

Answer 7

Heterocyclics

Question 8

Name the 2 MAOIs

Answer 8

1. Phenelzine

2. Tranylcypromine

Question 9

Name the 2 5-HT2 receptor Antagonists

Answer 9

1. Nefazodone

2. Trazodone

Question 10

3 Contraindications to Lithium Use

Answer 10

1. Dehydration
2. Cardio probs
3. Renal Probs

Question 11

Aside from CNS stimulation (agitation, convulsions), name 3 Key side effects of MAOIs

Answer 11

1. HTN rxn (especialy with tyramine-foods)
2. Hyperthermia
3. Orthostatic Hypotension

Question 12

Venlafaxine and Duloxetine are both _______

Answer 12

SNRIs

Question 13

Fluoxetine, Paroxetine, Sertraline are block the uptake of _______

Answer 13

Serotonin

Question 14

SNRIs share SSRI side-effects, but also includes which 3 side-effects?

Answer 14

1. Anticholinergic
2. Sedation
3. Hypertension

Question 15

Fluoxetine, Paroxetine, Sertraline, Citalopram, Escitalopram, and fuvovaxamine are all _________

Answer 15

SSRIs

Question 16

Venlafaxine and Duloxetine block the uptake of _____

Answer 16

SNRIs

Question 17

Mechanism of action for TCAs

Answer 17

Inhibit BOTH NE and 5-HT reuptake

Question 18

Name the 5 TCAS

Answer 18

1. Imipramine
2. Amitriptyline
3. Clomipramine
4. Desipramine
5. Nortriptyline

Question 19

Citalopram, Escitalopram, and Fluvoxamine all block the uptake of _____

Answer 19

Serotonin

Question 20

Name 6 SSRIs

Answer 20

1. Fluoxetine
2. Paroxetine
3. Sertraline
4. Citalopram
5. Escitalopram
6. Fluvoxamine

Question 21

Aside from decreasing thyroid function, Most common side effect with taking Lithium:

Answer 21

Tremor

Question 22

In regards to pharmacokinetic interactions, Paroxetine and Fluoxetine are potent inhibitors of ________

Answer 22

CYP 2D6

Question 23

What is special about the heterocyclic drug Mirtrazapine’s mechanism of action?

Answer 23

Inhibits serotonin auto-regulators to promote NE and Sero release

Question 24

Venlafaxine is metabolized via ________

Answer 24

CYP 2D6

Question 25

Most dangerous Antidepressant to OD on are __________

Answer 25

TCAs

Question 26

Imipramine, amitriptyline, Clomipramine, Desipramine, and Nortriptyline are all _______

Answer 26

TCAs

Question 27

Fluoxetine and Norfluoxetine has a long half-life of ____ _to _____ days

Answer 27

7-9

Question 28

SNRIS and TCA mechanism of action

Answer 28

Blocking both Sero and NE

Question 29

Nefazodone and trazodone are both _________ ________

Answer 29

Serotonin 5-HT2 Antagonists

Question 30

2 Key Antidepressant CYP2D6 inhibitors. (can boost TCA effects)

Answer 30

Paroxetine and Fluoextine

Question 31

TCAs are used for major depression, chronic pain, and _______

Answer 31

OCD

Question 32

Name the 2 Heterocyclic drugs

Answer 32

1. Bupropion

2. Mirtazapine