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Complete Pharmacology > Adrenergics, SNS Agents > Flashcards

Adrenergics, SNS Agents Flashcards

1
Q

Out of NE, Epi, and Isoproterenol, which gives lowest peripheral resistance?

A

Isoproterenol

Unopposed Beta 2

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2
Q

Propanolol, Nadolol, Pindolol, and timolol are all _____ Beta Blockers

A

Nonselective

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3
Q

Epinephrine MOA, which receptors? What happens to pulse pressure?

A

B1=B2,
a1=a2
Widens pulse pressure

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4
Q

Main side effect of Non-selective Alpha Antagonists?

A

Postural Hypotension

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5
Q

Prototypical Alpha 1 agonist

A

Phenylephrine

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6
Q

3 Main Non-Selective Beta Blockers

A
  1. Propanolol
  2. Nadolol
  3. Pindolol
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7
Q

Isoproteronol MOA? What happens to pulse pressure?

A
  • B1=B2

- Pulse pressure Drops

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8
Q

Prototypical Adrenergic Beta 1 agonist

A

Dobutamine

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9
Q

Name 4 Main B1 Selective Blockers

A
  1. Metoprolol
  2. Acebutolol (ISA)
  3. Nebivolol
  4. Esmolol
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10
Q

Dopamine at low doses vs High doses effects

A

Low: Increase renal perfusion & diuresis
High: B1 and Alpha Effect

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11
Q

Alpha-methyl dopa main side effect

A

Dug-Induced lupus

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12
Q

Two main Adrenergic Alpha 2 Agonists

A
  • Clonidine

- Alpha-Methyl Dopa

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13
Q

Two contraindications of Epi

A
  1. Hyperthyroidism

2. On non-selective Beta Blocker

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14
Q

3 Side effects of Dopamine

A
  1. Vent/SVT arrhythmias
  2. Wide QRS
  3. Angina
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15
Q

Adminster ______ to reverse Beta Blocker Toxcity

A

Glucagon

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16
Q

Phenoxybenzamine MOA

A

Irreversible a1=a2 Block

- Blocks vasoconstrict

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17
Q

Norepinephrine MOA, which receptors? What happens to pulse pressure?

A

B1»>B2 (no Beta2)
a1=a2
Pulse pressure mild boost (both SBP and DBP go up)

18
Q

Out of the 4 Alpha-1 Blockers, ) ______ has the longest half life and _______ is the most Uro-selective

A
  • Doxazosin

- Taumulosin

19
Q

Two Non-selective Alpha Antagonists

A
  1. Phenoxybenzamine (IRR)

2. Phentolamine (Rev)

20
Q

Metoprolol, Acebutolol (ISA), Nebivolol, Betaxolol, and Esmolol are all _____ Beta Blockers

A

B1

21
Q

Out of the B1 selective blockers, name why each is special.

  • Esmolol
  • Nebivolol
  • Acebutolol
A
  • Esmo is the shortest acting
  • Nebi is the longest acting
  • Ace has partial agonist
22
Q

Prazosin, Terazosin, Doxazosin, and Tamulosin are all ___ ____ ____

A

Selective Alpha 1 Blockers

23
Q

Alpha-methyl Dopa Main use

A

HTN in pregnancy

24
Q

Dobutamine MOA

A
  • B1 Agonist

- some alpha1 maintains resistance

25
Q

Phentolamine MOA

A

Reversible a1=a1 Block

- Blocks vasoconsrict

26
Q

Aside from cardiac arrest and heart block, what is Isoproteronol used for?

A

Stokes-Adams Attack

Syncope from brady

27
Q

Labetolol and Carvedilol are both _____ Beta blockers

A 
Mixed Nonselective
(Also block Alpha)
28
Q

Phentolamine and Phenoxybenzamine are both used to treat _______

A

Pheochromocytomas

29
Q

Pindolol is the weirdest Non-Selective Beta Blocker because:

A

It’s also Partial agonist to B1 and B2

30
Q

Clonidine 2 main uses

A
  1. Hypertensive Urgency

2. Anxiolytic

31
Q

2 uses for Dobutamine

A
  1. Cardiogenic Shock

2. Cardiac Stress test

32
Q

Never use Beta blockers for _______ Angina

A

Vasospastic

You want B2 to function

33
Q

Main side-effect of Phenylephrine

A

Supine HTN

34
Q

4 Selective Alpha 1 Blockers

A
  1. Prazosin
  2. Terazosin
  3. Doxazosin
  4. Tamulosin
35
Q

Prototypical Non-selective Beta Agonist?

A

Isoproteronol

36
Q

Alpha-Methyl Dopa MOA

A

Alpha 2 Agonist

- Decrease SNS outflow

37
Q

NE Major side effect?

A

Ischemic Necrosis

38
Q

Clonidine MOA

A

Alpha 2 agonist

- decrease tone, HR, SNS outflow

39
Q

Epi is used for _____ whereas NorEpi is used for _____ in ______ or _____ _____

A
  • Anaphylaxis
  • Hypotension, Sepsis
  • Cardiogenic Shock
40
Q

Phenylephrine MOA

A

Alpha 1 agonist constriction

Complete Pharmacology (25 decks)

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