Deck 4

Question 1

Pathogens engulfed by macrophages:

Answer 1

May survive and replicate in the macrophage phagocytic vesicles

Question 2

An inflammatory response recruits:

Answer 2

phagocytes to the infection site

Question 3

Lymphocyte recirculation:

Answer 3

Occurs for both naive and effector lymphocytes

Question 4

The regions of the antibody molecule which contribute MOST to the affinity of the antibody for antigen are the:

Answer 4

CDR

Question 5

T independent antigens does not:

Answer 5

get presented on MHC class II

Question 6

Superantigens induce:

Answer 6

CD4 T cells to produce cytokines that inhibit an immune response

Question 7

Type I hypersensitivities diseases:

Answer 7

Milk allergy in cattle: alpha casein gains access to circulation and stimulate immune response
Anaphylactic reaction
Atopic dermatitis
Food allergy
Drug allergy
Systemic anaphylaxis
asthma-like disease
Hay fever
Conjunctivitis
Hives
Anaphylactic shock

Question 8

Type II hypersensitivities diseases:

Answer 8

Haemolytic transfusion reaction
Haemolytic disease of newborn
Drug-induced haemolytic anaemia
Infectious agents induced haemolytic anaemia by bacterias, viruses etc.

Question 9

Type III hypersensitivities diseases:

Answer 9

Local reactions: Arthur’s reaction, blue eye and pneumonia
Systemic reactions: glomerulonephritis, arthritis, vasculitis, serum sickness, serum-sickness-like reaction by drugs, anaemia/leukopenia/thrombocytopenia

Question 10

Type IV hypersensitivities diseases:

Answer 10

Delayed type
Contact dermatitis
Tuberculin reaction
Glanders, malleus
Granulomas

Question 11

The ligand for TCR is:

Answer 11

MHC + peptide

Question 12

Gene conversion is a biological mechanism that

Answer 12

Increases the diversity of antibodies produced by plasma cells

Question 13

Th1 cells secretes cytokines which activate:

Answer 13

macrophages

Question 14

Toxic nitrogen radical example:

Answer 14

NO2
N2O4
N2O3
N2O5

Question 15

The typical class of antibodies formed during secondary immune response are:

Answer 15

IgG

Question 16

Immune system cell adhesion molecules (CAM) does not:

Answer 16

attract leukocytes to an infection site

Question 17

B-cell development in the bone marrow yields the mature B-cell with a membrane:

Answer 17

IgM molecule

Question 18

Invariant (Ii) chain:

Answer 18

Prevents exogenous binding to class II MHC in the endoplasmic reticulum
Is degraded in the MHC II compartment to CLIP

Question 19

What is NOT a similarity between the cellular and humoral immune response?

Answer 19

Cytokine signals promote effector cell differentiation
Memory cells are generated
Antigen-specific lymphocytes undergo clonal selection and expansion

Question 20

Type IV hypersensitivity involve _____________ of cells:

Answer 20

Cytotoxic T cell mediated lysis of cells