Deck 1 Flashcards
Histamine is produced by what cell?
Mast cell
What is a haptoglobin?
A protein i n the blood which binds haemoglobin from damaged red blood cells
What is haemoimmunoglobulin?
Peripheral lymphoid organs are designed to?
Maximize contact between antigen and lymphocytes
Facultative intracellular bacteria can survive for days due to their ability to:
Inhibit fusion of phagosome with lysosomes
Escape into cytoplasm
Be resistant to lysosomal enzymes
Macrophages kill pathogens using (4):
Nitric oxide
Oxygen radicals
Peroxides
Proteolytic enzymes
CD8 is a co-receptor on T cells that binds:
The constant region of class I MHC
Upon initial exposure to allergen, plasma cells secrete antigen-specific IgE that binds to mast cell FceRI. The mast cells are said to be:
sensitized
An antibody Fab contains (4):
Complementarity determining regions
H and L chain variable regions
One antigen binding region
One H-L interchain disulphide bonds
Phagocytosis can be stimulated by:
antigen binding to complement or antibody
A type III hypersensitivity reaction is mediated by:
Complement activation by immune complexes deposited in the blood vessel walls, kidneys and joints
An autoimmune disease mediated by type III hypersensitivity is:
Lyme arthritis caused by immune complexes resulting from a persistent infection with Borrelia burgdorferi
Complement is:
Activated by binding to specific complement receptors
Antigen-specific
A potent promotor of virus entry into host cells
A series of intracellular proteins which work with antibody to eliminate endogenous antigen
Present in the circulation in an inactive form
Recognition and killing of cancer cells by NK cells is a type of:
Innate immunity
Complement activation by a component of the bacterial surface is a type of:
Innate immunity
Antigen entering the body by intravenous injection activates antigen-specific lymphocytes in:
the spleen
The role of corticosteroids is to influence the activity of:
NF-kB as well as other transcription factors resulting in suppression of expression of different genes in activated T cells or macrophages
Signalling to a cytotoxic T cell that a cell is infected with a virus depends on:
binding of processed antigen to cell class I MHC
It takes how many days after antigen contact before T cells are armed effector cells?
4-5 days
Germinal centres are:
sites of rapid antigen-induced B cell division in the lymph nodes and spleen
