Deck 3

Question 1

Mast cells release their granule content to stimulate inflammation in response to:

Answer 1

antigen binding to IgE on mast cell FceR

Question 2

For the process of genetic recombination, which enzyme is required?

Answer 2

RAG

Question 3

NADPH require:

Answer 3

oxygen

Question 4

Cytokine reaction to cell close to them?

Answer 4

paracrine

Question 5

Rearrangement of both BCR and TCR gene segments does NOT:

Answer 5

Result in isotype switching after antigen stimulation of mature lymphocytes

Question 6

Non-steroidal anti-inflammatory drugs act by:

Answer 6

Inhibition of cyclooxygenase

Question 7

A common feature of all hypersensitivities are:

Answer 7

Inflammation

Question 8

Somatic hypermutation is a biological mechanism that:

Answer 8

Increases the specificity of antibodies produced by plasma cells

Question 9

Specific antibodies are readily detectable in serum following primary contact with antigen after:

Answer 9

5-7 days

Question 10

A fundamental difference between the antigen receptor on B cells (BCR) and on T cells (TCR) is their:

Answer 10

Different requirements for antigen presentation

Question 11

Antigen entering the body by intravenous or subcutaneous injection activates antigen specific lymphocytes in:

Answer 11

i.v. - spleen
s.c. - lymph nodes

Question 12

Th2 cells secretes cytokines which:

Answer 12

stimulate proliferation of B cell

Question 13

Invariant (Ii) chain prevents:

Answer 13

Prevents exogenous peptide binding to class II MHC in the endoplasmic reticulum
Is degraded in the MHC II compartment to CLIP

Question 14

Clonal selection:

Answer 14

Results in proliferation of antigen-specific lymphocytes

Question 15

Lymphocytes require their antigen-specificity by:

Answer 15

somatic recombination

Question 16

The effect of interferons on cells during viral infection is reflected in the ability of these cells to produce antiviral proteins. These proteins include enzymes which cleave:

Answer 16

viral RNA

Question 17

To detect a humoral immune response to influenza virus, you would measure:

Answer 17

Serum antibody titre

Question 18

During the lag period between antigen contact and detection of adaptive immunity:

Answer 18

innate immune effectors are eliminating antigen

Question 19

A virus vaccine that can activate cytotoxic T cells MUST contain:

Answer 19

live virus

Question 20

Complement activity is restricted by

Answer 20

DAF
CD55
C4bp
Factor H
Crry found in rodents