Connective Tissue Histology Flashcards
What are the two major groups of CT?
Embryonic (contains pluripotent stem cells)
Adult
These cells produce collagens, proteoglycans, and glycoproteins.
Fibroblasts
Theses cells are CT stem cells.
Mesenchymal cells
These cells store and release fats.
Adipocytes
These cells produce and maintain cartilage components.
Chondrocytes
These cells produce bone components.
Osteoblasts
These cells produce RBCs and immune cells (i.e., macrophages, mast cells, lymphocytes, plasma cells).
Hematopoietic stem cells
Collagens (several different types, type-I most common) – resists ________.
Tension
This is a stretchable fiber.
Elastin
These fibers form a supportive meshwork.
Reticular fibers
This type of collagen fibers are aligned and cross linked to increase tensile strength. In electron micrographs, banding of collagen fibers is observed due to fibril alignment.
Type-I collagen
This is due to a vitamin C deficiency, which is a co-factor in cross-linking collagen fibers. This weakens the CT.
Scurvy
This disease is due to an abnormal collagen synthesis leading to weak collagen fibers (multiple forms).
Ehlers-Danlos Syndrome
In the ECM of CT there is amorphous ground substances. These include…
Proteoglycans
Hyaluronan
Glycoproteins
Extracellular proenzymes
What proteoglycans are part of the amorphous ground substance?
Chondroitin sulfates
Heparan sulfates
Keratan sulfates
What glycoproteins are part of the amorphous ground substance?
Cytokines
Growth Factors
Structure Proteins (i.e., fibronectin, laminin, etc.)
_______ receptors bind specific ECM components and initiate intracellular signaling.
Integrin
This type of CT is rich in ECM and mesenchymal stem cells (multipotent).
Embryonic CT