Components of the blood Flashcards
What is in the blood
Plasma, red blood cells, white blood cells and platelets
What is in plasma
Ions, gases, water, waste, hormones, proteins, nutrients etc
What are red blood cells known as
Erythrocytes
How much of our blood do red blood cells make up
40-45%
Function of red blood cells
Deliver oxygen to our tissues using haemoglobin
Specialisations of red blood cells
Biconcave shape, no nucleus, small
Function of erythropoietin
Stimulate red blood cell synthesis
Life span of red blood cell
100 -120 days
How many red blood cells does an adult have
Approx 20 -30 trillion
How much of our cells do red blood cells represent
70%
Where does haemoglobin bind
Lungs - high partial pressure as high saturation of oxygen
Where does haemoglobin dissociate
Tissues - low partial pressure as low saturation of oxygen
What does sickle cell do red blood cells
Causes them to become long and flat
Life expectancy of someone with sick cell
40-60 years
What causes sickle cell
A change in the beta globin gene (6th codon) DNA changes from GAG to GTG
What is anaemia
Low rbc count or lower amounts of haemoglobin in circulation
What is polycythemia
High haemotacrit - high amount of blood that is rbc. Due to high rbc production or low plasma level
Normal range of wbc
Men: 4.7- 6.1 million/ ul
Women: 4.2-5.4 million/ ul
What are platelets known as
Thrombocytes
Role of platelets
Blood clotting
Normal platelet count
150,000 - 450,000/ ul
Low platelet count
Less than 50,000 - thrombocytopenia
What are white blood cells known as
Leukocytes
Function of monocytes
Differentiate into macrophages, respond to inflammation & bacterial infection - blob shaped
Function of eosinophils
Target parasites and inflammation - boob shaped
Function of basophils
Release histamine, initiate inflammatory response - - grape shaped
Function of neutrophil
Respond to microbial infection and fungi - bunch shaped
Function of lymphocytes
Production of antibodies
Which wbc is the most abundant
Neutrophil
Normal wbc count
3,500 - 10,500
Lower than normal wbc count name
Leukopenia
High than normal wbc count name
Leukocytosis
mnemonic to remember prevalence of wbc
Never Let Monkeys Eat Bananas
Neutrophils - 60-70% Leukocytes - 20-30% Monocytes - 1- 6% Eosinophils - 1-3% Basophils - less than 1%
How much of our total blood volume is plasma
55%