Communicable Diseases Flashcards
What are three different types of immunity?
Active immunity
Passive immunity
Cross immunity
What is active immunity?
Produced by own immune system.
Long term, in some cases life long.
Natural.
Vaccines.
What is passive immunity?
Transferred from another person. Eg. mother to infant, transfusion of blood products, immune globulins.
Produced by animals (anti toxins).
Temporary.
What is cross immunity?
Immunity from one virus or bacteria provides protection against another.
How early was small pox recorded as an epidemic?
Record of epidemic as early as 1350 BC
What role did small pox play on a global scale?
Instrumental in the destruction of Aztec and Inca empires and decimated the indigenous population in Canada after European contact.
Who developed the small pox vaccine, and when?
Vaccine developed by Dr. E. Jenner in 1796
When did the WHO launch a campaign to eradicate smallpox?
1967 WHO launched campaign to eradicate.
When was small pox declared eradicated?
May 1980
Define “communicable disease”.
A contagious disease of human or animal origin caused by an infectious agent.
What are the characteristics of communicable diseases? (6)
Infectivity Pathogenicity Virulence Toxicity Invasiveness Antigenicity
What is infectivity?
The ability to enter and multiply in the host.
What is pathogenicity?
The ability to produce a specific clinical reaction after infection occurs.
What is virulence?
The ability to produce a severe pathological reaction.
What is toxicity?
The ability to produce a poisonous reaction.
What is invasiveness?
The ability to penetrate and spread throughout a body tissue.
What is antigenicity?
The ability to stimulate an immunological response.
What are the goals of communicable disease control?
To decrease the occurrence, spread, and complications of diseases.
To eliminate and eradicate vaccine-preventable disease.
What are some components of communicable disease control programs?
Immunization Outbreak management Accurate immunization record-keeping Compilation of immunization coverage data Maintenance of vaccine potency Reduction of vaccine wastage Reporting of adverse events.
When was the last polio epidemic in Canada?
1959
When was the polio vaccine developed, and by who?
Developed in 1955 by Dr. Jonas Salk
What does “eliminate” mean? (in respect to communicable diseases)
Remove a disease from a geographical area (eg. country or region).
What does “eradicate” mean? (in respect to communicable diseases)
World wide removal of the disease
What are the responsibilities of federal/provincial/territorial governments?
They control communicable disease programs. Each province has a different one.
What are the steps of developing a vaccine? (4)
- Lab studies
- Pre-clinical goals
- Clinical
- Health Canada approval
What occurs during the lab studies step of developing a vaccine? (first step)
Identify infectious agent
What occurs during the pre-clinical goals step of developing a vaccine? (second step)
Immunogenicity
Safety studies
Who are vaccines being tested on during the pre-clinical goals step of developing a vaccine? (second step)
At this phase, it is being tested on animals.
What are the three phases of the clinical step of developing a vaccine? (third step)
Phase 1 - looking at immunogenicity and local systemic reactions (human reactions at this point)
Phase 2- looking at an optimal dosing schedule in your target population, and ongoing safety assessment.
Phase 3 - looking at immunogenicity of a target population, and ongoing safety assessment.
How many participants are involved in phase 1 of the clinical step of developing a vaccine? (third step)
Participants range from 10 to less than 100
How many participants are involved in phase 2 of the clinical step of developing a vaccine? (third step)
Participants range from 50-500
How many participants are involved in phase 3 of the clinical step of developing a vaccine? (third step)
Participants range from 300-30,000
What is variolation?
Variolation was a technique used by the turks and the Chinese to protect against smallpox. It’s the technique of transferring the infection from an infected person to a non-infected person through a scratch in the skin. The non-infected person would contract a mild infection and survive and be immune for life.
What are the reasons for capitalized letters vs lowercasse letters in vaxine titles? Eg. DTaP vs Tdap
When you see a capital letter, it means you are getting the full dose. A lower case letter means you are getting a reduced dose.
DTaP - Diptheria, Tetanus, acellular Pertussis full doses
vs Tdap - full dose of tetanus with reduced doses of acellular pertussis and diptheria
What are classifications of communicable diseases?
- Agents of bioterrorism
- anthrax
- smallpox
- botulism - Under MHO mandate:
- vaccine preventable
- food-borne water-borne
- vector-borne
- diseases of travelers
- Zoonoses
- Parasitic
- sexually transmitted infections
- tuberculosis
What are some viral vaccine preventable diseases?
Rubeola Mumps Rubella Varicella Hepatitis A and B Influenza Poloimyelitis HPV Rotavirus
What are some examples of bacterial vaccine-preventable diseases?
Dipterhia Tetanus Pertussis Haemophilus influenza type B Invasive pneumococcal disease Meningococcal C
What are some examples of killed/inactivated vaccines?
Meningococcal, diptheria
What are some examples of live attenuated vaccines?
MMR, varicella, flu mist
What are toxoids?
Protect against injury from bacterial toxins but are not bacteriocidal.
What are some examples of toxoids?
Tetanus toxoid
What are immune globulins?
These protect you for a short period of time until your immune system is activated
What is an example of an immune globulin?
Rabies immune globulin
What are some contraindications of receiving a live/attenuated vaccine?
Immunocompromised
Under 12 months of age (these babies are protected by their maternal antibodies)
Received another vaccine within past 28 days
Recent blood transfusion
What route are live/attenuated vaccines given? What about killed/inactivated?
Live attenuated are generally given subcutaneously
Killed/inactivated are generally given IM
What are 6 examples of rashes in infants and children?
Rubeola Rubella Roseola infantum Impetego Fifth disease Hand, foot & mouth disease
What is the appearance of a rubeola rash?
Dusky red blotch rash spreading down from face
What is the appearance of a rubella rash?
Slightly raised, red pinpoint rash spreading from behind ears to face and downward.
What is the appearance of a roseola infantum rash?
Raised red rash on trunk, after 3-4 days of high fever, which spreads to rest of body.
What is the appearance of impetego?
Moist, purulent yellow crusted sores surrounded by redness