Coccidian II Flashcards
Though rare, it has a wide geographical distribution (higher prevalence in warmer climates).
Isospora Belli
The least common of the intestinal coccidia that infect humans.
Isospora Belli
Can cause severe disease with fever, malaise, persistent diarrhea and even death in AIDS patients.
Isospora Belli
Monoxenous (required one host) , probably not zoonosis: Asexual and sexual multiplication occurs in man.
Isospora Belli
Mode of Transmission: Human are probably infected by accidental hand-to-mouth ingestion of mature oocyst in food and water.
Isospora Belli
Habitat: Distal duodenum and proximal jejunum.
Isospora Belli
It may be from mild gastrointestinal distress to severe dysentery.
Clinical Manifestations — Isospora Belli
The loose, pale yellow and foul-smelling stools are suggestive of?
Malabsorption process
Infections are often asymptomatic and self -limiting.
Clinical Manifestations — Isospora Belli
There may be diarrhea over a period of several months to 15 years.
Clinical Manifestations — Isospora Belli
There may be chronic diarrhea, vague or crampy abdominal pain, weight loss, weakness, malaise and anorexi
Clinical Manifestations — Isospora Belli
The name is dervived from Greek: sarx means?
flesh
cystis means
bladder
rare human infection.
Sarcocystis
heteroxenous parasite
Sarcocystis
originally identified as 2 species.
Sarcocystis
taxonomic confusion
Sarcocystios
[2] generally named after host species
- Sarcocystis hominis
- Sarcocystis suihominis
[2] heteroxenous parasite
- predator-prey life cycle
- humans support both stages
originally identified as [2] species
intestine - isospora
tissue - sarcocystis
First human case reported in 1976.
Cryptosporidium spp.
Self-limiting diarrhea in immunocompetent persons.
Cryptosporidium spp.
Profuse, watery diarrhea associated with AIDS (life threatening).
Cryptosporidium spp.
Disease: Cryptosporidiosis
Cryptosporidium hominis
Common cause of diarrhea among travelers and in day care centers.
Cryptosporidium hominis
World wide in distribution.
Cryptosporidium hominis
Can occur as water-borne outbreaks.
Cryptosporidium hominis
Zoonosis from domestic animals.
Cryptosporidium hominis
More common in children than adult.
Cryptosporidium hominis
- 4-5 mm oocysts
- 4 sporozoites
- no sporocysts
Cryptosporidium hominis
Brush border of the mucosal epithelium of the stomach or intestine.
Habitat of Cryptosporidium Hominis
May involved the gallbladder and pancreatic duct.
Habitat of Cryptosporidium Hominis
Villi of intestine: infiltration of inflammatory cells into the lamina propia and elongated crypts.
Pathogenesis of Cryptosporidum Hominis
Diarrhea and Nausea and vomiting, abdominal cramps, weight loss and fever.
Clinical manifestations of Cryptosporidium Hominis
First human case in 1979.
Cyclospora Cayetanensis
Name in 1993
Cyclospora Cayetanensis
Initially called ‘cyano-bacteria like body’ (CLB) or large Cryptosporidium
Cyclospora Cayetanensis
no known animal reservoir.
Cyclospora Cayetanensis
More common in tropical and sub-tropical areas.
Cyclospora Cayetanensis
Infection most common in HIV/AIDS patients.
Cyclospora Cayetanensis
In freshly passed in stools, the oocyst is not infective (direct fecal oral transmission cannot occur; this differentiates from Cryptosporidium).
Cyclospora Cayetanensis
In the environment, sporulation occurs after days or weeks at temperatures between 22°C to 32°C, resulting in division of the sporoblast into two sporocysts, each containing two elongate sporozoites.
Cyclospora Cayetanensis
8-10 mm oocyts
2 sporocysts
2 sporozoites each
Cyclospora Cayetanensis
Fresh produce and water can serve as vehicles for transmission
Cyclospora cayetanensis
birds
C. baileyi
cat
C. felis
birds
C. baileyi
cat
C. felis
turkeys
C. meleagridis
mouse
C. muris
fish
C. nasorum
mammals
C. parvum
humans
C. hominis