Coagulation Cascade Flashcards
What are the parts of the coagulation cascade?
Intrinsic pathway
Extrinsic pathway
Common pathway
What triggers the intrinsic pathway?
Vessel wall damage
What happens in the intrinsic pathway?
Factor 12 activated
Activates factor 11
Activates factor 9
Factor 9 and factor 8 activate factor 10
What triggers the extrinsic pathway?
Tissue factor released by damaged tissue
What happens in the extrinsic pathway?
Factor 7 binds to tissue factor
Activates factor 9
Factor 9 and factor 8 activate factor 10
What happens in the common pathway?
Activated factor 10 causes the conversion of prothrombin to thrombin
Thrombin hydrolysis fibrinogen to form fibrin
What blood test is used to measure the intrinsic pathway?
APTT
Which factors are involved in the intrinsic pathway?
Factors
- 8
- 9
- 11
- 12
What blood test is used to measure the extrinsic pathway?
PT
What factor is involved in the extrinsic pathway?
Factor 7
What factors are involved in the common pathway?
Factors
- 2 (thrombin)
- 5
- 10
