Anaemia Flashcards
What is anaemia?
Low haemoglobin
What are the symptoms of anaemia?
Shortness of breath
Tiredness
Palpitations
Headache
What are the signs of anaemia?
Pallor
Tachycardia
Tachypnoea
Hypotension
What is koilonychia?
Spoon nails
What is koilonychia associated with?
Iron deficiency
What is glossitis?
Shiny enlarged tongue
What is glossitis associated with?
Vit B12 deficiency
What is angular stomatitis?
Sores at the corner of the mouth
What is angular stomatitis associated with?
Iron deficiency
What is Plummer Vinson syndrome?
Rare disease characterised by
- iron deficiency anaemia
- glossitis
- cheilosis
- oesophageal webs
Why might anaemia occur?
Reduced erythropoiesis Defects in haemoglobin synthesis Defects in red cell metabolism Loss of red cells Removal of RBCs by RES
What causes reduced erythropoiesis?
Empty bone marrow
Lack of response in haemostatic loop
Dyserythropoiesis
When does dyserythropoiesis occur?
Anaemia of inflammation
Anaemia of chronic disease
What can cause defects in haemoglobin synthesis?
Lack of iron
Lack of B12/folate
Mutations in proteins
What can cause defects in red cell membrane structure?
Hereditary spherocytosis
Hereditary elliptocytosis
Mechanical damage to cells
Heat damage