Anaemia Flashcards

1
Q

What is anaemia?

A

Low haemoglobin

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2
Q

What are the symptoms of anaemia?

A

Shortness of breath
Tiredness
Palpitations
Headache

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3
Q

What are the signs of anaemia?

A

Pallor
Tachycardia
Tachypnoea
Hypotension

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4
Q

What is koilonychia?

A

Spoon nails

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5
Q

What is koilonychia associated with?

A

Iron deficiency

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6
Q

What is glossitis?

A

Shiny enlarged tongue

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7
Q

What is glossitis associated with?

A

Vit B12 deficiency

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8
Q

What is angular stomatitis?

A

Sores at the corner of the mouth

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9
Q

What is angular stomatitis associated with?

A

Iron deficiency

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10
Q

What is Plummer Vinson syndrome?

A

Rare disease characterised by

  • iron deficiency anaemia
  • glossitis
  • cheilosis
  • oesophageal webs
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11
Q

Why might anaemia occur?

A
Reduced erythropoiesis 
Defects in haemoglobin synthesis
Defects in red cell metabolism 
Loss of red cells 
Removal of RBCs by RES
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12
Q

What causes reduced erythropoiesis?

A

Empty bone marrow
Lack of response in haemostatic loop
Dyserythropoiesis

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13
Q

When does dyserythropoiesis occur?

A

Anaemia of inflammation

Anaemia of chronic disease

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14
Q

What can cause defects in haemoglobin synthesis?

A

Lack of iron
Lack of B12/folate
Mutations in proteins

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15
Q

What can cause defects in red cell membrane structure?

A

Hereditary spherocytosis
Hereditary elliptocytosis
Mechanical damage to cells
Heat damage

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16
Q

What can cause defects in red cell metabolism?

A

G6PDH deficiency

Pyruvate kinase deficiency

17
Q

How can anaemia be evalulated?

A

By mechanism
By size
By presence or absence of retiulocytosis

18
Q

What can cause anaemia with reticulocytosis?

A

Acute blood loss
Splenic sequestration
Haemolysis

19
Q

How is anaemia with low reticulocyte count be further evaluated?

A

Size

  • microcytic
  • normocytic
  • macrocytic
20
Q

What can cause microcytic anaemia?

A
Thalassaemia 
Anaemia of chronic disease
Iron deficiency 
Lead poisoning 
Sideroblastic anaemia
21
Q

What can cause normocytic anaemia?

A

Primary bone marrow failure

Secondary bone marrow failure

22
Q

What can cause macrocytic anaemia?

A
Vitamin B12 deficiency 
Folate deficiency 
Myelodysplasia 
Liver disease
Hypothyroidism 
Alcohol