CIC: To Review Flashcards
Bacteria/ Viral/ Fungi/ TB: Opening pressure in CSF analysis
Bacteria: Elevated
Virus: Usually normal
Fungi: variable
TB: Variable
Bacteria/ Viral/ Fungi/ TB: Glucose e in CSF analysis
Bacteria: normal to decreased
Virus: usually normal
Fungi: Low
TB: Variable
Bacteria/ Viral/ Fungi/ TB: Predominate inflammatory cell in CSF analysis
Bacteria: Neutrophils (early or partially treated may have lymphocyte predominance)
Virus: Lymphocytes
Fungi: Lymphocytes
TB: Lymphocytes
Bacteria/ Viral/ Fungi/ TB: WBC Counts in CSF analysis
Bacteria: >=1000/mm^3
Virus: <100/ mm^3
Fungi: variable
TB: variable
Bacteria/ Viral/ Fungi/ TB: Total protein in CSF analysis
Bacteria: Elevated
Virus: Normal to elevated
Fungi: elevated
TB: elevated
Bacteria/ Viral/ Fungi/ TB: Staining in CSF analysis
Bacteria: Gram stain shows gram positive or gram negative
Virus: Gram stain negative
Fungi: India ink, positive
TB: AFB stain positive
Urgent threats
1) carbepenem resistant acinotobacter
2) candida auris
3) clostridioides difficile
4) carbepenem-resistant enterobacterales
5) drug-resistant Neisseria gnorrhoaea
Serious threats
-drug resistant campylobacter
-drug resistant candida
-esbl producing enterobacterales
-vancomycin resistant enterococci
-multidrug resistant pseudomonas aeruginosa
- drug resistant salmonella (both non typhi and typhi)
- drug resistant shigella
-mrsa
- drug resistant strep pneumonia
- drug resistant TB
Concerning threats
Erythromycin resistant GAS
Clindamycin resistant group B strep
Describe high temp sterilization
Steam (apprx. 40 min) or dry heat (1-6 hours depending on temp). Use for heat-tolerant critical surgical items
What is the modified toluidine blue stain used for?
Resp tract parasites and fungi
Ex) pneumocystis jerovecii
What is the trichrome stain used for?
Cysts, trophozites, parasites in stool
What is the wright gimesa stain used for?
Parasites in blood
What organisms is the beta lactamase test used for?
Strep and pseudomonas
What is the disk approximation test used for?
Clindamycin resistance in staph
Types virulence factors
- Adhesins
- exoenzymes
- toxins
- ability for antigenic variation
Steps of pathogenesis
1) exposure
2) adhesion
3) invasion
4) infection (multiplication)
Purpose of glycocalx
Facilitates attachment of bacteria to plastic devices and interferes with penetration of water soluble antibiotics
What organisms causes most ssi within 24 hours?
Strep pyogenes
Types of granulocytes
Neutrophils
Basophils
Eosinophils
Prophylactic antibiotic for pneumocystis jerovecii
Tmp/smx
Endogenous opportunistic organisms of the lungs
M TB
Coccidioides
Histoplasma
Pneumocystis jerovecii
Endogenous opportunistic agents that infect the skin
Staph aureus
Coagulase negative staph
Maladsezia furfur
HSV
Herpes zoster
Endogenous opportunistic organisms that infect the GI tract
Enterococcus
Streptococcus bovis
Colostrum septicum
Candida
Aerobic gram negatives
Endogenous opportunistic organisms that infects the CNS
Toxoplasma gondii
Examples of exogenous opportunistic organisms from hands of hcp
Gram negative
Staph aureus
C diff
Viruses
Examples of exogenous opportunistic organisms from water
Legionella
Crypyosporidium
Examples of exogenous opportunistic organisms from soil, dust, and env
Rhodococcus
Aspergillus
Zygomycetes
NTM
Do endospores in Bacillus spp. and Lactobacillus spp. stain?
No
Spirochetes
Treponema, Boirrelia, Leptospira
Are gram stains effective for spirochetes?
Not usually, but may be detected by darkfield flourescent microscopy
Stain for Cryptococcus neoformans in CSF
India ink
Stain for parasites in stool, including giardia, entamoeba, and endolimax
Trichrome
CSF: Predominant cell neturophil
Bacterial meningitis
CSF: predominant cell lymphocyte
Viral meningitis
CSF: predominant cell eisoinophil
Parasite or fungal meningitis (ie coccidioides)
Classic indicators of bacterial meningitis
Increased WBC
Increased protein
Decreased glucose
What CSF typically looks like for TB meningitis
lymphocytes
low glucose
Which is preferred for lower respiratory culture: bronchoscopy or sputum sample?
Bronchoscopy, such as BAL
Less or more sensitive: POC tests for Group A strep and fly
less sensitive
When are surveillance cultures for staff appropriate?
Not routinely, only when staff implicated in cluster/ outbreak
Types of antibody tests
EIA
Chromogenic immunoassay
Hemagglutination
Latex agglutination
Fluorescent antibody tests
Western Blot
Sensitivity and specificity for HCV RNA
Good sensitivity and specificity
Specificity of urine legionella EIA/ fluorescent antibody test
100% and also has good sensitivity
How reliable are tests for histo, coccidioides, and blastomyces?
High cross-reactivity with other fungi/ poor test reliability
Describe RPR
Screening test for syphilis, high sensitivity, so need confirmatory testing if positive
Specimen Collection Guidelines
1) Use standard precautions for collecting and handling all clinical specimens
2) Use appropriate collection devices
3) Use sterile equipment and aseptic technique
4) Collect specimens during acute phase of the illness (or within 2-3 days for viruses)
5) Collect specimens before administration of antibiotics whenever possible
6) Avoid contamination with indigenous flora from surrounding tissues, organs, or secretions
7) Optimized the capture of anaerobic bacteria from specimens by using proper procedures
8) Collect sufficient volume of specimen to ensure that all tests requested may be performed
9) Proper label: pt name, source, specific site, date, time of collection, and initials of collector
10) Provide clear/ specific instructions on proper collection technique to patients getting their own sample
Specimen Transport Guidelines
1) transport promptly to lab (preferably within 2 hours of collection)
2) Transport in container designed to ensure survival or suspected agents
3) Label properly, package, and protect during transport. Can use transport medium to preserve viability of microbes
4) leak-proof specimen containers and transport in sealable, leak-proof plastic bags
5) Never transport syringes with needles attacched
6) labs must have enforceable criteria to reject unsuitable specimens
What samples should NEVER be refrigerated?
CSF, genital, eye, inner ear
Common transport media
Stuart, amies, carey-blair
Common blood culture contaminants
S. epidermindis
Bacillus spp.
Propionbacterium
S. viridans
Modes of action of antimicrobials
- interfere with cell wall synthesis
- inhibit protein synthesis
- interfere with nucleic acid synthesis
- inhibit metabolic pathway
Leukocytosis (>10,000 WBC) is a sign of
Acute infection
Leukopenia (<4000 WBC) is a sign of
Overwhelming infection:
AIDS
viral hepatitis
Mononucleosis
Legionairre’s disease
Neutrophilia (increase) is a sign of
Inflammation
Bacterial infection
Neutropenia is a sign of
Overwhelming bacterial infections
viral infections (hep, flu)
What diseases cause an increase in basophils?
TB
Smallpox
Chickenpox
Influenza
What diseases cause an increase in monocytes?
- Bacterial infections
TB
Subacute bacterial endocarditis
syphillis
Diseases that cause lymphocytosis (increased >4000)
Infectious mononucleosis
Viral URI
CMV
Measles
Mumps
Chickenpox
Viral Hepatitis
Describe sensitivity
Good sensitivity - Detect sick people
High sensitivity: false positives, confirmatory testing needed
Low - more false negatives
Where are each of the following endemic:
Histpplasma capsulatum
Blastomyces dermatidis
Coccidioides immitis
Histo: Mississippi and Ohio River Valley
Blasto: acidic soil, “”
Coccidioidies: Southwest/ south and central CA
Describe specificity
Good specificity: Health people test negative
High specificity: more false negative, miss some cases
Low specificity: more false positives
What can cold agglutination tests detect?
- mycoplasma pneumo
- mono
- viral pneumo
Diseases with positive C-reactive protein
Meningitis
Pneumonia
Sepsis
TB
What does LAL (Limulus amebocyte lysate) test for?
Endotoxins
Organisms with endotoxins
- E coli
- Salmonella
- Shigella
- Pseudomonas
- Neisseria
- H. influenzae
- B. pertussis
- V. cholera
What organisms with the weil-felix agglutination test detect?
Rickettsia illnesses:
RMSF
Q Fever
Typhus
Rickettisal pox
How do antibiotics work?
- interfere with cell wall biosynthesis
- inhibit bacterial ribosomes
- interfere with DNA replication or RNA transcription
- inhibit metabolic pathways
Pharmacokinetic description for antibiotics
Best pharmodynamic parameters for beta-lactam drugs
Time > MIC
Drug of choice for susceptible enterococcus and Listeria
Aminopenicillins
What bacteria does pipercillin/ tazobactam (zosyn) cover, and what type of antibiotic is it?
Beta-lacatam (penicillin + beta-lactamase inhibitor)
Used as empiric in combination with vanco
Covers Gram + and pseudomonas
Cephalexin
Cefazolin
1st gen cephalosporin
Cefotelan
Cefoxitin
Cefuroxime
2nd gen cephalosporin
Ceftriaxone
Cefotaxime
Cefdinar
Ceftazidime
3rd gen cephalosporin (increasing gram - activity)
cefepime
4th gen cephalosporin (still covers some gram + (strep) and good coverage for gram -, pseudo,
Ceftraoline
5th gen cephalosporin
MRSA and Pseudomonas
Best pharmadynamic for fluoroquinolones
AUC: MIC
Best pharmadynamic for aminoglycosides
Cmax/ MIC
Carbepenems effective against
gram -
Fluoroquinolone examples
Ciprofloxacin
Levofloxacin
What is are fluoroquinolones used for?
gram negative
mechanism of fluoroquinolones
Inhibit bacterial enzymes
Describe tetracyclines
Static
Inhibit protein synthesis at the ribosome
Describe aminoglycosides
Inhibit protein synthesis
cidal
Combo drug for serious gram - MDROs
Examples of aminoglycocides
Amikacin
Gentamicin
Describe macrolides
Static
Inhibit protein synthesis
less serious infections
Examples of macrolides
Ezithromycin
Azithromycin
Clarithromycin
How does TMP-SMX (bactrim) work? What group does it belong to? What is it effective against?
interfere with bacterial folic acid synthesis
sulfanimide
UTI/ oral option MRSA/ Nocardia
Examples tetracyclines
tetracycline
monocycline
Doxycycline
Describe glycopeptides
Vancomycin
concentration dependent (AUC)
MRSA coverage, Staph, Strep, Enterococci
Acts at site of cell wall
Describe use of Linezolid uses
Gram +
Static- oral MRSA but not BSI
Activity against vancomycin resistant bugs
Describe daptomycin uses
Gram + cocci (but not strep)
cidal
vancomycin resistant bugs
Acts at cell membrane
Clindamycin uses
Think above the belt
Mostly gram +
static
Metronidazole uses
Think below the belt
Anaerobes, mostly gram negative
What is rifampin used for?
N. meningitidis
TB
What does successful antimicrobial therapy depend on?
BUG: virulence and susceptibility of the organism
DRUG: activity of the antimicrobial at site of infection
HOST: immunocompromise of host
SITE: body site of infection
What are oral options for MRSA?
Clindamycin, Doxycycline, TMP-SMX, and Linezolid
Bacterial resistance mechanisms
Efflux pumps
Enzyme
Alteration of target site:
Decrease porins
structure mutation
Decrease uptake
presumptive dx of TB in CSF
Lymphocytic pleocytosis (increase in lymphocytes)
hypoglycorrhacia (low glucose in CSF)
Toxicity of TB treatment
Occular and liver
Treatment for active TB
Months 1-2- Isoniazid (INH), rifampin (RIF), pyrazinamide (PZA) , and ethambutol (EMB)
Months 3-6 (up to 12 mos)- INH and RIF
How often should sputum samples be taken for active TB patients?
monthly
Latent TB therapy
9 months- INH
4 months- RIF
and monitor for active TB
When is someone contagious with influenza?
24 hours before, 3-5 days after but up to 7 days
Who should get antivirals for influenza?
Younger than 2, older than 65
immunosuppressed
Pregnant or 2 weeks post partum
Morbid obesity
CC resident
American Indian/ Alaskan native
Less than 19 on aspirin
Chronic conditions
Parts of virus identification
Virus Type/ Place/ Strain #/ Year/ Virus Subtype
A/ Sydney/ 05/ 97 (H3N2)
Pandemic influenza Phase:
Education- flu symptoms/ isolation
Vaccine
Facility plans for surge
Exp management plans
Just-in-time training plans
Comm plans
Phase 1-3
No human to human transmission
Phase?
Est # HCP needed
Start to increase isolation capacity
Review exposure management plan
Plan to sustain operation
Visitor screening plan
Staffing guidance for cases
Phase 4
Limited human- human transmission
Phase?
Enhanced screening and surveillance
Just-in time training
Schedule staff communications
Incident command
Phase 5
Sustained human to human transmission
Phase?
Implement surge strategy, staffing, supplies, and space
Cancel elective procedures
Implement employee exposure management plan
Phase 6
Efficient and widespread human - human transmission
Influenza iPC Plan
- early ID and isolation of patients
- annual education
- Vaccine to patients and HCP
- restrict ill patients and HCP
How long should flu pt be in isolation?
Private room, 7 days after onset and fever free for 24 hours
PEP for flu
High risk setting OB- antivirals for 2 weeks
Incubation for Hep A
28 days
(15-50 days)
How long does the prodromal phase of Hep A last in symptomatic patients? and the iciteric phase?
Prodromal (ILI, nausea, vomit)- 1-2 weeks
Iciteric Phase (jaundice, dark urine, pale stool, itch): up to 6 months
Window period for Hep A IgM test
5-10 days, within 3 weeks of exposure
Incubation for Hep B
90 days
(60-150 days)
Describe when each of the Hep tests will become positive:
HBsAg
HBeAg
anti-HBC
anti-HBS
HBV-DNA
HBsAg- 30 days
HBeAg- 30 days
anti-HBC- symptom onset
anti-HBS- after recovery
HBV-DNA- 30 days
Hep C incubation
2-12 weeks
(15-160 days)
Window period for anti-HCV and HCV RNA
Anti-HCV- 8-11 weeks
HCV RNA- 1-2 weeks after exposure
Testing for exposure to Hep C
Test ASAP and again 3-6 weeks after , RNA can detect earlier than anti-HCV
4th leading cause of community acquired pneumo
Legionella pneumophila
What increases the risk for aspiration of Legionella?
Intubation
Gen anesthesia
Nasogastric tube
Describe testing for legionella
Culture- 100% specific, 80% sensitive, use special selective media
Urinary antigen - sensitivity 80-90% and specificity 90-100%
DFA- Direct Fluorescent Antibody
Does not gram stain
Symptoms Legionnaire’s DIsease
Infiltrate in lungs
nonpurlent cough
pleural chest pain
Fever of 104
confusion*
hypoatremia (low sodium)
Incubation and recovery time pontiac fever
24-48 hours
2-5 days, self-limited
Treatment for legionella
quinolones and macrolides
Steps water safety plan
Describe H2O system
Assess risks
Control Risks
Audit
What are C. Diff toxins?
Toxin A
Toxin B
Binary toxin
Surge capacity: how many weeks should you have adequate resources available for?
6-8 weeks
Category: Brucellosis
B
Category: epsilon toxin Clostrium perfringens
B
Category: Food safety threats
B
Category: Glanders (burkholderia mallei
B
Category: Nipah virus
C
Category: Melloidosis (burkholderia pseudomallei)
B
Category: hantavirus
C
Category: Influenza
C
Category: Anthrax
A
Category: Smallpox
A
Category: Psittacosis (chlamydia pssitaci)
B
Category: Q Fever
B
Category: Ricin
B
Category: SARS
C
Category: Botulism
A
Category: Rabies
C
Category: Q fever (Coxiella Burnetti)
B
Category: Staphylococcol entertoxin B
B
Category: typhus fever (Rickettsia prowazecki)
B
Category: MDR-TB
C
Category: Plague
A
Category: Tularemia (Francisella tularensis)
A
Category: Yellow Fever
C
Category: Viral encephalitis
B
Category: Tickborne hemorrhagic
C
Category: Viral hemorrhagic fevers
A
Category: water safety threats
B
Precautions for fever >101.1F and cough in children
Droplet and contact
Precautions for vomitting
Standard
Precautions for watery or explosive stools, with or without blood
Contact
Precautions fever and rash
airborne
Precautions fever, upper chest rash, and stiff/ sore neck
Droplet
precautions eye infections
Standard
Precautions itchy rash without fever
Contact
Precautions petechial/ erythyromotic rash with fever
Droplet for 24 hours of antimicrobial therapy
Precautions: rash, positive history of travel to area with current outbreak of VHF in 10 days before onset
Droplet, contact, eye protection. Add N95 for aerosol generating procedures
Precautions macoulopapular rash with cough, coryza, fever
Airborne
Precautions vesicular rash in centrifugal pattern
Airborne and contact
What category of agents can be transmitted during autopsy? Which diseases is it unsafe to handle the dead bodies?
A
Choloera
VHF
smallpox
What are the two types of viral hemorrhagic fevers?
Filoviruses
Arenaviruses
Describe cutaneous anthrax
Incubation 1-12 days
Bulla develops and turns into necrosis
Standard and contact if copious drainage
Describe respiratory antrhax
Incubation 1-7 days
ILI progresses to dyspnea, shock, death in 85-90% untreated
Std precautions (not P2P)
If facility site of release or aerosolization: N95 or PAPR
PEP: vax + 60 days doxy or cipro
Describe botulism
Ingest/ inhale toxin
Incubation 1-5 days
Descending paralysis, resp failure
Standard precautions
Describe ebola
Transmission: mucous membranes, resp tract, broken skin/ percutaneous injury to body fluids of infected pt
Incubation: 5-10 days, up to 19
Symptoms: Vom, diarrhea, fever, hypotension, shock, hemorrhage
Precautions: Standard (esp HH, needle safety) + contact + droplet (or N95 for aerosol generating procedures)
Describe plague
inhalation
Incubation: 2-3 days
chills, ha, cough, dyspnea, rapid progression weakness and hemoptysis, circulatory collapse, bleeding diathesis
Precautions: standard and droplet for 48 hours after antibiotics
PEP for exposed HCP
Describe tularemia
Inhalation or ingestion
Incubation: 3-5 days
Symptoms: Pneumatic or typhoidal
Precautions: Standard
High risk: lab workers
Describe smallpox
Inhalation droplet/ contact with skin lesion
Incubation: 7-19 days
Symptoms: ILI vomit, centrifugal maculpapular rash around day 4 (more on face and extremities), and all lesions at same stage
Precautions: standard, contact, airborne for 3-4 weeks until all scabs separated
PEP: Vax within 4 days
IP for smallpox vax
cover vax site with guaze and semi-permeable dressing until scab separates (approx 21 days)
Adverse event:
- standard and contact until lesions crusted
Enteric:
onset 8-16 hours, lasts 24-48 hours, from meats, stews, gravies, vanilla sauce, vegetables, and milk products
Bacillus cereus
Enteric:
Onset 2-5 days, lasts 2-10 days
Symptoms: diarrhea, cramps, fever, vomiting, diarrhea, may be bloody
Source: Raw and undercooked poultry, unpasteurized milk, contaminated water
Campylobacter
Enteric:
Incubation: 8-16 hours, lasts 24-48 hours
Symptoms: Watery diarrhea, nausea, abdominal cramps, fever rare
Source: Meats, poultry, gravy, dried or precooked foods, time and/ or temp abused food
Clostridium perfrigens toxin
Enteric:
incubation 1-8 days, lasts 5-10 days
Symptoms: severe bloody diarrhea, abdominal pain, vomit, no fever
Source: undercooked beef (esp hamburger), unpasteurized milk and juice, raw fruits and vegetables, contaminated water
EHEC
Enteric:
Incubation 1-3 days, lasts 3-7 days
Symptoms: Watery diarrhea, abdominal cramps, some vomit
Source: Contaminated water or food
ETEC
Enteric:
Deadly for infants within a few days old
Cronobacter sakazakii
Enteric:
Incubation: 9-48 hours
Symptoms: Fever, muscle ache, nausea, diarrhea. Invasive disease within 2-6 weeks.
Source: fresh and soft cheese, unpasteurized milk, ready to eat deli meats, hot dogs
Listeria monocytogenes
Complications of Listeria monocytogenes
Pregnant women- premature delivery and stillbirth
Elderly/ immunocompromised- bacteremia or meningitis
Enteric:
Incubation 1-3 days, lasts 4-7 days
Symptoms: diarrhea, fever, abdominal cramps, vomiting
Sources: contaminated eggs, poultry, unpasteurized milk or juice, cheese, contaminated raw fruits and veggies
Salmonella spp
Enteric:
Incubation 24-48 hours, lasts 4-7 days
Symptoms: abdominal cramps, fever, diarrhea with blood and mucous
Source: ready to eat foods touched by infected workers, not common
Shigella
Enteric:
Incubation: 1-6 hours, lasts 24-48 hours
Symptoms: sudden onset of severe nausea and vomiting
Source: unrefrigerated meats, potato salad, and egg salads, cream pastries
S. aureus (entertoxin)
Enteric:
Incubation: 1-7 days, lasts 2-8 days
Symptoms: vomiting, diarrhea, abdominal pain, bacteremia, and wound infections
Source: undercooked or raw shellfish, especially oysters
Vibrio vulnificus
Complications of vibrio vulnificus
Immunocompromised or chronic liver disease: can be fatal
Enteric:
Incubation 24-48 hours, last 1-3 weeks
Symptoms: Appendicitis-like symptoms and vomiting, erythema nodosum
Source: undercooked pork, unpasteurized milk, tofu, contaminated water
Yersinia enterocolitica
Enteric:
Incubation period: 28 days, lasts 2-3 weeks
Symptoms: Diarrhea, dark urine, jaundice, ILI
Source: Shellfish, raw produce, contaminated drinking water, undercooked foods, foods handled by infected food handler
Hep A
Enteric:
Incubation: 12-48 hours, lasts 12-60 hours
Symptoms: Nausea, vomiting, ab cramping, diarrhea, fever, myalgia
Source: hands of HCP, P2P, aerosolized vomit, water
Norovirus
Enteric:
Incubation: 1-3 days, lasts 4-8 days
Symptoms: vomiting, watery diarrhea, low-grade fever
Risk: children, immunocompromised, elderly
Source: close contact within households, foods touched by infected workers
Very common childhood illness
Rotavirus
Prevention for rotavirus
Vaccine
Enteric:
Incubation: 3-4 days, sheds up to 35 days
Symptoms: watery diarrhea
Source: Shellfish, water, fomites
Astrovirus
Enteric:
Incubation: 8-10 days, last 2 weeks
Risk: Children under 4
Symptoms: Protracted diarrhea, or asymptomatic
Source: fecal/oral, droplet, transplants, p2P
Enteric adenovirus
Precautions for adenoviruses
Contact and droplet
Enteric:
Incubation 2-10 days
Symptoms- diarrhea, stomach cramps, slight fever, remits and relapses
Source: drinking water, undercooked food, food handled by sick food handler
Cryptosporidium
Enteric:
Incubation: 1-14 days
Symptoms: diarrhea, loss of appetite, substantial weight loss and fatigue
Source: fresh produce (berries), water, usually imported goods or related to travel
Cyclospora
Enteric:
Incubation period 1-2 weeks
Symptoms: malodorous diarrhea, malaise, flatulence, weight loss
Source: contaminated food or water, person to person
Giardia lamblia
Enteric:
Incubation 2-3 days to 1-4 weeks
Symptom: diarrhea for 1-6 weeks
Source: uncooked food or food contaminated by food handler, drinking water
Entamoeba histolytica
Enteric:
Incubation 5-23 days, or at birth in infants, lasts months
Symptoms: asymptomatic, lymphadenopathy, CNS in immunocompromised patients
Source: ingestion cat feces, raw/ partly cooked meat, perinatal
Toxoplasmosis
Enterobacteriaceae- lactose fermenters
E. coli
Citrobacter
Klebsiella
Enterobacter
Enterobacteriaceae- non-lactose fermenter
Salmonella
Shigella
Proteus
Pseudomonas
This virulence factor in gram-negative bacteria activates macrophages, white blood cells, releases cytotoxin, and causes septic shock, necrosis, DIC, and death
Lipid A endotoxin
This virulence factor provides resistance to antibodies, production of toxins, hemolysins, chromosomal or plasmid mediated
Pathogenic Islands
Virulence factor that helps Enterobacteriaceae evade immune mechanisms and phagocytosis
K antigens (capsule)
Virulence factor that helps Enterobacteriaceae with motility and adherence to GI and urinary epithelial cells
H antigens (Flagellar)
What antibiotics are carbapenemase producing klebsiella pneunominae resistant to?
Cephalosporins
monobactams
carbapenems
Enterobacteriaceae in the top 10 CLABSIs
Klebsiella
Enterobacter
E. Coli
Top Enterobacteriaceae for VAP
Klebsiella
Top Enterobacteriaceae for HAP
Enterobacter
Klebsiella
E. Coli
Top Enterobacteriaceae for HAI CAUTI
1) E. Coli
2) Klebsiella
3) Proteus
4) Enterobacter
5) Serratia
What HAIs does E. Coli typically cause?
CAUTI
CLABSI
VAP
SSI
What HAIs does Enterobacter cause?
Lower resp infections
UTI
wounds infections
Septecemias
Concern for Enterobacteriaceae
Multi-drug resistance, so treatment usually carbepenem
Motile fermenters Enterobacteriaceae
E. coli
Enterobacter
Serratia
Non-motile fermenter Enterobacteriaceae
Klebsiella
Motile non-lactose fermenters Enterobacteriaceae
Salmonella
Proteus
Non-motile, non lactose fermenting Enterobacteriaceae
Shigella
Yersinia
3 As of Klebsiella
Alcoholics, abscesses, aspiration
Carbepenemase producing genes
KPC
NDM
IMP
NDM
OXA-48
What antibiotic still typically works for CRE?
Fluoroquinolones
Most common flu strains in the last 30 years
H3N2
H1N1
TPN contamination
Fungi: C. albicans most freq, malassazia furfur
Gram + bacteria: Coagulase - staph
Gram - bacteria: E. coli, pseudomonas
Most common ESBL
Klebsiella and E. Coli
What antibiotics are ESBL resistant to?
third generation cephalosporins
monobactams
Common commensals that contaminate blood cultures
Corynebacterium
Bacillus
Propionibacterium
Coagulase-negative staph
Viridans group strep
Aerococcus spp.
Micrococcus spp.
Definition CLABSI (commensal)
2 positive cultures of common commensals from 2+ sets of blood cultures drawn <2 days apart AND patient has symptoms (fever, chills, hypotension)
Components of effective antimicrobial stewardship programs
1) leadership and culture
2) timely and appropriate antibiotic initiation
3) appropriate admin and deescalation
4) Data monitoring and reporting
Strategies for antimicrobial stewardship:
- Pharmacy restriction of meds
- audit and feedback
- antibiotic timeouts
- automatic stop orders
- documented indication
- dose optimization
- De-escalation (IV- oral)
Cultures that are NOT suitable for anaerobic culture and why
Why: contamination with resident anaerobic flora
Sputum
rectal swab
nasal/ throat
Urethral swab
Voided urine
Percentage of population exposed to coccidiodies in endemic regions
50%
Scabies incubation
4-6 weeks
RSV precautions
Contact + standard for duration of illness (mask when appropriate under standard precautions)
Most common cause of epidemic GI illness worldwide
Noro
Five major control factors for foodborne pathogens
1) person hygiene
2) adequate cooking
3) avoid cross-contamination
4) Keep food at safe temp
6) avoid foods from unsafe sources
Test for WNV
positive IgM- goes to public health lab
Precautions rabies
Contact precautions and eyewear and mask or face shield to protect mucous membranes
Shape of Borrelia burgdorferi
Spirochete
Primary causative agent transient aplastic crisis
Parvovirus B19
Treatment for parvovirus B19 in immunocompromised
immunoglobulin therapy
Precautions parvovirus B19
Droplet precautions
Resistance of Parvovirus B19
resistant to detergents, solvents, and heat. Stays in the environment for a long time
Symptoms parvovirus B19
Most asymptomatic
Slapped cheek rash (erythema infectiosum or fifth’s disease)
Prodrome: low-grade fever, cold symptoms
Few days later- rash
Infectious from symptom onset- 7 days after, most infectious in first 2 days
Incubation for parvovirus
4-14 days
Rash appears 2-3 weeks after infection
How parvovirus B19 transmitted
Droplet/ fomite, blood transfusion, vertical transmission
Complications parvovirus B19
spontaneous abortion in first 20 weeks of pregnancy
Transient aplastic crisis
Symptoms parvovirus in fetus
first trimester infection: anencephaly, spontaneous abortion
Second trimester: fetal hydrops and severe anemia
How long to isolate parvovirus B19 patient in transient aplastic crisis
7 days after admission, droplet or hospital stay if immunosuppressed
Surface proteins RSV
F (fusion)
G (attachment)
SH (small hydrophobic)
Infection control RSV
- HH
- cough etiquette
- cleaning/disinfection
- droplet and contact precautions
Most common cause of hospitalization for respiratory disease in chlidren
RSV
Incubation RSV, and when contagious
2-8 days
symptom onset until 3-8 days later
Treatment RSV
Palivizumab for high risk
Commensal fungi in GI tract and female genital tract
Candida albicans
Risk factors for fungal infections
Broad spectrum antibiotics
CVC
Immunosuppression
Neutropenia
Urinary catheter
Prothesis
TPN
When should you suspect candidemia?
High-risk patients with unexplained fever (esp if on broad spectrum antibiotics) or unexplained CNS signs and symptoms
Max hang time for lipid containing infusions
12 hours
Clinical presentation of aspergillus
cavitation/ fungal balls in the lungs/ fever/ hemoptysis
Most common viruses to cause meningitis
HSV, enteroviruses, arboviruses, mumps
Where does meningitis typically stem from?
organisms that colonize the nasophyrnyx
Precautions bacterial meningitis
H. influenzae and n. meningitidis- droplet 24 hours after appropriate microbial therapy
Precautions for aseptic meningitis
typically standard
Testing for CJD
- Western blot on brain tissue
- immunohistochemical tests for PrP on fixed tissue
- analysis of DNA extracted from blood or brain
- analysis of CSF for 14-3-3 protein
Highly infectious tissue CJD
Brain
Dura matter
Pituitary tissue
Spinal cord
Eye
*not CSF listed as low infectivity
Iatrogenic transmission of CJD
- pts exposed directly to infectious prion materials via inadequately sterilized neuro equip
- contaminated dura matter
- corneal transplants
- cortical electroencephalogram electrodes
- injections of cadaveric pituitary-derived growth hormone
4 chemicals that work on CJD
Chlorine
Phenol
Guanidine thiocyante
Sodium hydroxide
Parameters of pre-sterilization (before normal sterilization process from cleaning- sterilization) for CJD
prevac sterilizer- 134F- 18 min
Gravity displacement sterilizer- 132F- 1 hour
NaOh- 1 hour
How to clean contaminated surfaces with CJD
1:10 dilution sodium hypochlorite for 15 inutes
Reduction of red blood cell hemoglobin to methemoglobin leading to a green or brown zone of discoloration surrounding the colony on a blood agar plate
alpha-hemolysis
Complete lysis of red blood cells leading to a clear (transparent) zone surrounding the colony on a blood agar plate.
beta-hemolysis
Exotoxin produced by certain bacteria that have the ability to trigger excessive inflammatory immune response
Superantigen- examples: Strep pyogenes, S. dysgalactiae, S. equi
Group Strep A clinical
Pharyngitis
Scarlet fever
Erysipelas
Impetigo
Cellulitis
Necrotizing fascitis
Streptococcal toxic shock syndrome
Culture: white-to-gray colonies, 1 to 2 mm in diameter, and are surrounded by clear, colorless zones within which the red blood cells in the medium have been completely lysed
GAS, different from other beta-hemolytic strep because it’s susceptible to bacitracin
Gene to type for GAS
emm gene (codes for virulence factor)
If a patient has a sore throat, white spots, but a negative rapid antigen detection test for GAS, does that rule out strep?
No, test has 80-90% specificity so should culture
Precautions- Major GAS skin, wound, or burn infection that is draining
droplet, contact, and standard until 24 hours after initiation of effective therapy
Precautions GAS pharyngitis
Droplet until 24 hours after effective therapy
Precautions Scarlet fever
droplet for 24 hours after initiation of effective therapy
Precautions for strep pyogenes(GAS)
Droplet for 24 hours after initiation of effective therapy
Precautions group b strep neonatal disease
Standard
Precautions Strep pneumo, drug resistant
Standard, contact
Precautions non-drug resistant strep pneumo
standard
Risk factors for group b strep to infant born to colonized mother
- preterm delivery
- prolonged membrane repture during labor
- maternal fever during labor
- maternal history of prior infant with GBS sepsis
Most common cause of adult bacterial meningitis in the U.S.
Strep pneumo
Culture: gram +, α-hemolysis with partial lysis of red blood cells leaving a zone of greenish discoloration
Viridans group strep
Types of strep
GAS, GBS, viridans group strep, group C strep (animals), Group D strep (colon cancer, GI)
What are the common staph HAIs?
Bacteremia
Endocarditis
Pneumonia
Osteomylitis
SSI
Skin and soft tissue infections
Device associated infections
Risk factors for HA- MRSA
- LOS in hospital
- chronic wounds
- catheters
- antibiotics
MRSA resistance
Beta-lactams
macrolides
clindamycin
tetracycline
quinolones
aminoglycoside
Most common organism to infect CSF shunts
Staph epidermidis
How to dx scabies
prep skin with India ink to see burrows, microscopic examination of mites, or PCR
Treatment for scabies
Topical scabicide
Incubation scabies
4-6 weeks, as little as 10 days
Precautions scabies
Contact until 24 hours after treatment, may be longer for crusted scabies
PEP for scabies
Treatment for household members and intimate contacts
Outbreak response: scabies
Treat entire population at risk over the same 24-48 hour period, whether or not symptoms present and wash all clothing on hot cycle
Temp to kill scabies
Hot water wash at 122F for at least 10 minutes, and 10 minute dry
OR put linens in bag for 10 days
Survival of lice and lice eggs outside of host
2 days for head lice
30 days for eggs
Kill lice on personal items
140F for 5-10 min
Seal in bag 10-14 days
Freeze in bag for 12-24 hours
Human infestation of fly larvae
Myiasis
Kill bed bugs on personal items
Hot water wash at 120F for 10-20 minutes or freeze items
Heat items in room to 118 for 1 hour
Serogroups N. meningitidis
A, B, C, X, Y, W-135
Ages impacted by N. meningitidis
<5 years, 21 years, 65+
5 clinical manifestations of N. meningitidis
1) Bacteremia
2) Meningocomcemia without meningitis
3) Menigitis with or withouth meningococemia (70%)
4) Meningococcal encephalitis
5) Meningococcal pneumonia
What rash is commonly associated with N. meningitidis?
Petechial or purpuric rash
What condition related to a rash can lead to death from a N. meningitidis patient?
Purpura fulminans
What is a risk factor for meningococcal pneumonia?
Recent infection with virus
Antibiotics for N. meningitis
penicillin G and cephalosporins
When is vaccine for N. meningitiidis recommended?
Routine:
- all children 11 or 12
-Booster at 16-18
Campaign:
-3 cases from same serogroup in community <3 months
PEP for N. meningitidis
24 hours- 14 days after exposure
Rifampin
Ciprofloxacin
Ceftriaxone
Most common cause of encephalitis
Enterovirus (Coxsackievirus)
Period of communicability for N. meningitidis
7 days before onset to 24 hours after antimicrobial therapy
Incubation/ TBP/ HCP restriction/ PEP: conjunctivitis
Incubation: 24-72 hours
TBP:
viral- contact and standard
bacterial- standard
Restriction: Pt contact and pt env until discharge ceases
Incubation/ TBP/ HCP restriction/ PEP: acute diarrheal illness
Incubation: Varies
TBP: Contact for diapered and incontinent for duration of illness, may need negative stool samples
Restriction: pt contact, pt env, food until symptoms resolve
Incubation/ TBP/ HCP restriction/ PEP and post-exposure work-restrictions: Diphtheria
Incubation 2-5 days
TBP: Droplet until off antibiotics and 2 negative cultures 24 hours apart
Restriction: Exclude from duty until antimicrobial therapy complete and there are 2 negative samples
PEP: Exclusion and antibiotics
Incubation/ Symptom/ TBP/ HCP restriction/ PEP: Enterovirus (Coxsackie/ echovirus)
Incubation: 3-6 days
Symptom: resp, fever, rash, mouth sores
Contact: diapered or incontinent for duration of illness
Restriction: restrict from care of infants, neonates, and immunocompromised until symptoms resolved
Common name for coxsackie virus (which is an enterovirus)
Hand, foot, and mouth
Incubation/ TBP/ HCP restriction/ PEP Hep A
Incubation: Approx 28 days (15-50 days)
TBP: contact for diapered and incontinent until 1 week after jaundice, unless <3 years old and that is for duration of hospitalization
HCP: restrict from pt contact, pt env, and food handling until 1 week after jaundice
PEP: Hep A vax within 2 weeks
Incubation/ TBP/ HCP restriction/ PEP Hep B
Incubation: 90 days (60-150)
TBP: std, hemodialysis get their own space and equip
HCP: panel review exposure prone procedures
PEP: Source HBsAg positive and HCP susceptible- Hep B vax and HBIG
Incubation/ TBP/ HCP restriction/ PEP Herpes
Incubation: 2-12 days
Contact for severe/ disseminated disease until lesions dry and crust
Restrictions:
Herpetic whitlow: HCP from pt contact/ pt env until lesions dry and crust
Orofacial- cover and restrict from patient care immunocompromised
Incubation/ TBP/ HCP restriction/ PEP HIV
Incubation: 1-6 weeks
Standard precautions
restrictions: panel review for invasive exposure prone procedures/ local/ state health regs
PEP: within 72 hours, PEP will depend on pt viral load
Incubation/ TBP/ HCP restriction/ PEP and post-exposure work-restrictions: Measles
Incubation: 10-12 days to symptoms, 14 days to rash
TBP: airborne and standard until 4 days after rash onset
Restriction: Exclude for 7 days after rash onset
PEP: exclude day 5-21 if exposed and no symptoms, 4 days after rash if one develops
Vax within 72 hours of exposure or Immunoglobulin within 6 days
Incubation/ TBP/ HCP restriction/ PEP and post-exposure work-restrictions: meningococcal disease
Incubation: 2-10 days
TBP: droplet for 24 hours after initiation of effective therapy
Restriction: exclude from duty until 24 hours after effective therapy
PEP: prophy antibiotics within 24 hours for HCP without mask and close contact (intubation, mouth to mouth, suctioning), household, partners
Incubation/ TBP/ HCP restriction/ PEP and post-exposure work-restrictions: mumps
Incubation: 16-18 days (12-25 days)
TBP: Droplet until 5 days after parotitis onset (updated from 9)
Restrict: exclude from duty until 5 days after parotitis (updated from 9)
Post exposure: Exclude susceptible days 12-26 or 5 days after parotitis
Incubation/ TBP/ HCP restriction/ PEP and post-exposure work-restrictions: Pediculosis
Incubation: 7-10 days
TBP: contact until 24 hours after initiation of therapy
Restrict: no patient contact until treated and observed lice free (24 hours after initiation of therapy)
Incubation/ TBP/ HCP restriction/ PEP and post-exposure work-restrictions: Pertussis
Incubation: 7-10 days (6-21 days)
TBP: Droplet until 5 days start of antibiotics
Restriction: Exclude until 5 days after the start of effective therapy
PEP: Z-pack
Incubation/ TBP/ HCP restriction/ PEP and post-exposure work-restrictions: Rubella
Incubation: 14 days (12-23 days)
TBP:
congenital: contact until 1 year old
Adult: droplet for 7 days after rash onset
Restriction: Exclude until 5 days after rash onset
Post-exposure: Exclude susceptible day 7- day 21
PEP: Vax within 72 hours in non-pregnant, susceptible contacts
Incubation/ TBP/ HCP restriction/ PEP and post-exposure work-restrictions: Staph aureus
Incubation: Varies
TBP: furunculosis/ draining lesions: contact until wounds stop draining
Restriction: Draining lesions: restrict from pt contact, pt env, and food until lesions no longer draining
Incubation/ TBP/ HCP restriction/ PEP and post-exposure work-restrictions: GAS
Incubation: varies
TBP: Droplet, contact if lesions present for 24 hours after start of appropriate therapy
Restrictions: pt care, pt env, and food until 24 hours after effective antimicrobial therapy
Incubation/ TBP/ HCP restriction/ PEP and post-exposure work-restrictions: Active TB
TBP: airborne, draining lesions- contact and airborne until effective therapy, improving, and 3 consecutive negative sputum smears 8-24 hours apart
Restriction: exclude HCP until deemed non-infectious
Post exposure: test immediately and 12 weeks after exposure
Incubation/ TBP/ HCP restriction/ PEP and post-exposure work-restrictions: Varicella zoster
Incubation: 14-16 days (10-21 days)
TBP: Airborne and contact (but no mask for vax, no recommendations for surgeon or N95 for susceptible) until all lesions crust and dry
Restriction: Exclude until all lesions crust and dry
Post exposure: Exclude susceptible day 10-day 21 (28 for VZIG)
PEP: Vax within 5 days, VZIG for preg and immunocompromised
Incubation/ TBP/ HCP restriction/ PEP and post-exposure work-restrictions: Herpes zoster
TBP:
Localized immunocompetent- standard
Disseminated immunocompetent: airborne and contact
Disseminated or localized immunocompromised: airborne and contact
For duration of illness
Restriction:
Localized: cover lesions, restrict from high risk patients until all lesions crust and dry
Generalized or immunocompromised: restrict from pt contact until lesions crust and dry
Post exposure: susceptible exposed to disseminated or immunosuppressed pt: exclude from day 10 - day 21 (28 VZIG)
Incubation/ TBP/ HCP restriction/ PEP and post-exposure work-restrictions: Ebola
Incubation: 8-10 days (2-21)
TBP: Droplet, standard, and contact for duration of illness
Exclusion: Exclude for duration of illness
Post exposure: State regs differ- exclusion may be for 21 days post exposure
Incubation/ TBP/ HCP restriction/ PEP and post-exposure work-restrictions: Scabies
Incubation: 4-6 weeks
TBP: contact until 24 hours after start of effective therapy
Restriction: restrict from pt contact/ pt env for 24 hours after effective therapy
Contagious period for measles
1-2 days before until 4 days after rash
3 cs of measles prodromal phase
Cough, coryza, conjunctivitis
Word to describe measles rash
Morbiliform
Complications of measles
- otitis media
- bronchopneumonia
- bronchitis
- splenomegaly
- encephalitis
- death
Condition that may occur years after measles infection in the very young
Subacute sclerosing panencephalitis (SSPE)
transport of measles test specimen
ASAP- measles liable
4 degrees C (freezing causes loss of virus)
sample early in acute phase
What vitamin deficiency is related to measles?
Vitamin A
Vaccine info for MMR
Live attenuated
Give at 12 months and before school (4-6 years)
Who should not receive the MMR vaccine?
Pregnant
Severely immunocompromised
Recent recipients of immunoglobulin or blood products
If another patient was exposed to a measles case and is susceptible, what is recommended for the exposed pt?
- AIIR for 5-21 days after exposure
- Vax within 72 hours
Contagious period mumps
1-2 days before until 5 (formerly 9) days after parotitis
% of mumps patients that are asymptomatic
30-40%
When is the highest risk for congenital rubella?
early pregnancy in first 12 weeks
Symptoms congenital rubella
- retarded growth
- mental retardation
- congenital heart disease
- deafness
- ocular abnormalities
- anemia
- hepatosplenomegaly
- increased miscarriages
- increase stillbirths
Rubella symptoms adult
25-50% asymptomatic
otherwise prodrome with ILI and then maculopapular rash, arthritis, and arthralgia (in women) for 3-5 days
Contagious window for rubella
7 days before rash until 7-14 days after rash
Testing: rubella
Send to CDC for confirmation
Usually use serology (IgM or paired IgG) since viral iso difficult
Typical age range for mumps cases
5-19 years old
Primary virulence factor for pertussis
Pertussis toxin
How does pertussis toxin work?
PT prevents migration of lymphocytes to areas of infection and adversely affects phagocytosis and glucose metabolism, causing compensated insulinemia
Complications of pertussis:
pneumonia
seizures
encephalopathy
death
Describe the vaccine for pertussis
Acellular vaccine
4 doses DTAP (2,4,6, and 15-18 months)
Booster 4-6 years
TDAP- 11-18 years (best around 11-12)
Every pregnancy
19+- Tdap for adults that never received a dose
Recommendations if multiple patients exposed to pertussis?
PEP and cohort
additional measures for more extensive respiratory outbreaks/ community spread
Universal masking
limit visitation
exclude sick children from daycare
Herpes viruses
HH1 (HSV-1)
HH2 (HSV-2)
HH3 (VZV)
HH4 (EBV)
HH5 (CMV)
HH6 (HHV-6)
HH7 (HHV-7)
HH8 (KSHV)
HHV that causes:
B cell lymphoma
Hodgkin lymphoma
NP carcinoma
Hairy leukopenia
EBV
Common name for HHV-6 and HHBV-7
Roseola
HHV that can cause:
Primary effusion lymphoma
Multicentric Castleman disease
HHV-8 Kaposi Sarcoma
HHV that causes gingivostomatitis
HSV-1
What differentiates chickenpox and measles:
Measles: conjunctivitis, rash appears on forehead, hacking cough, koplik spots
Chickenpox: rash appears on chest, face and back, decreased appetite, spots turn into itchy blisters
Symptoms congenital CMV
- petechiae (blueberry muffin rash)
- jaundice
- hepatosplenomegaly
- microcephaly
- hearing loss
- eye abnormalities
- developmental delays
Type of virus herpes
DNA
Life threatening herpes virus for patients with severe skin conditions like burns
Eczema herpeticum
Biggest complications risk for Varicella
Secondary bacterial infection
Healthcare populations of concern for herpes viruses
Immunocompromised
Solid Organ transplants
Hematopoietic stem cell transplants
Most common disease to cause birth defects in the United States
CMV
Illness that causes gray baby syndrome (Pallor, hypotension, and resp destress) in preterm babies infected after transfusion
CMV
Clinical outcomes of AIDS and transplant recipients that get CMV
Interstitial pneumonia
Cytomegalo-retinitis
Cytomegalo-enteritis (GI issues)
What is the mortality rate of post-transplant lymhoproliferative disease from EBV?
50%
95% of children are infected with this disease by age 3
HH6 (roseola)
Concerns for HHV6 in transplant recepients
- HSCT can reactivate
Allogenic transplants- can cause graft rejection
Screening recommendations for HIV
once age 13-64
more frequently (every 6 months- 1 year for higher risk behavior)
Most common opportunisitic infections HIV
Pneumocysitis jiroveci
TB
Disseminated mycobacterium avium
Disseminated mycobacterium kansasaii
CDC core strategies for HIV
1) Dx
2) Prevent
3) Treat
4) Respond
Tests for HIV and description:
1) rapid antibody tests (23-90 days after infection), require confirmation for positive with HIV antibody differentiation immunoassay
2) Viral p24 antigen/ antibody test (venous 18-45 days after exposure, fingerprick (18-90 days after exposure)
3) NAAT (10-33 days after exposure)
Work restrictions for hcp with RSV
HCP with acute resp symptoms should NOT provide care to high-risk patients
When to provide education about MDROs
At hire and routinely as changes occur
Elements of an occupational health program
1) Educate HCP about IP and their responsibility for IP
2) Investigate exposures to OBs
3) Provide care to HCP with work-related illness/ exposure
4) ID infection risk to preventative measures
5) contain costs by preventing infectious diseases that result in absenteeism/ disability
Elements of a the respiratory protection program:
- Person specially trained to oversee program
- administrator evaluate effectiveness of program
- training & demonstration of use by employee
- Sufficient number, models, and sizes
- Fit test annually or as needed
- Seal check with each use
Elements of exposure control plan and how often to review
Annually
1) protective measures provided by employer
2) engineering/ work practice controls
3) PPE
4) HBV vax within 10 days of hire
5) Training
Ways to measure needlestick injuries
Occupied Beds: Needlesticks / Bed/ Year:
# needlesticks/ total occupied beds
Occupation: Needlesticks/ nurses/ year
# needlesticks reported by nurses/ # full time nurses employed
Device-based rate: needlesticks/ device type/ year
# needlesticks from device type/ # device type used or purchased
General HIV PEP
Most exposures warrant 2 drug regimen with:
2 nuceloside reverse transcriptase inhibitors (NRTIs) or
1 NRTI and 1 nucleotide reverse transcriptase inhibitor
What are the components of a successful occupational health
1) leadership and management
2) Communication, collaboration, assessment, and reduction of risk for HCP
3) Medical evaluations
4) Occupational education and training for infection prevention including essential precautions for disease transmission
5) Management of testing protocols and return to work guidelines
6) HCP treatment
7) Immunizations
8) Testing protocols
9) management of potentially infectious exposures and responses
What’s the recommendation for MMR if born before 1957?
If no immunity per lab evidence for rubella, get 1 dose of MMR
If exposure to varicella occurs after vaccination series is started, does HCP need to be exluded?
No, but they should be monitored for symptoms daily days 10-21 (or 28 if they get VZIG)
When should meningitis PEP be started?
within 24 hours of exposure, no more than 2 weeks
What antibiotics for meningitis PEP are contraindicated for pregnant women?
Rifampin
Cipro
They can take ceftriaxone
unique symptom of Hep B
Scleral icturus
When to test for HCV after exposure
Baseline testing for anti-HCV and ALT, RNA testing at 4-6 weeks after exposure, then repeat anti-HCV and ALT at 4-6 months after exposure
When to test for HIV after exposure
Baseline, follow up testing for 6 months
Timeline to start HIV PEP
72 hours
Higher risk HIV exposures
Patient symptomatic, has AIDS or high viral load
Exposure from large hollow needle, deep puncture, needle used in patient artery or vein
When would you use an expanded 3-drug PEP for HIV?
PT HIV class 2 for less severe or more severe exposure
OR
PT HIV class 1, but there is a more severe exposure
What PEP is most often recommended for mucous membrane exposures to HIV?
2-drug unless patient HIV class II and large volume of blood into mucous membrane
How to make IVs and central lines safer for HCP
Replace IV, aerterial, and central line tubes with needless or blunt canula devices
What can be done to make scalpels safer
round tipped scalpel blades
alternative material blades (silicone)
retractable, disposable blades
Hierarchy of controls
Most effective to lease effective:
Elimination
substitution
engineering
administrative controls
PPE
What vaccine contain egg?
MMR and influenza
What vaccines contain thimerosal?
DTAP, DT, Td
Influenza
Meningococcal
Who should avoid live vaccine?
- Pregnant or planning to become pregnant in 28 days
- Symptomatic HIV
- Treatment induced immunosuppression
- Malignancy
- Receipt of antibody production within window of vax
Immunoglobulin available for these diseases
Hepatitis A
Hepatitis B
Chickenpox
Tetanus
Measles
Rubella
Rabies
Who is considered at risk and should get the Hep B vaccine?
- STI treatment facilities
- HIV testing and treatment facilities
- drug abuse treatment/ prevention
- healthcare targeting MSM/ drug/users
- correctional facilities
- hemodialysis
- developmental disabilities
- HCP with risk to blood exposure
What age group should not get LAIV?
> 49 years (higher risk for severe complications from flu)
How many doses of MMR and how far apart?
2 doses, 28 days apart, after 1st bday
Can you give MMR vaccine and the TST test at the same time?
Yes, same day as vaccine or wait 4 weeks for TST
Can you give live vaccines at the same time?
Yes, but you should give them the same day OR wait until 28 days between live vaccine if not the same day
Can patients with HIV get the MMR vaccine?
Yes if asymptomatic and CD4 >15%
What is a potential side effect of rubella vaccine in adults
increased risk of arthritis and arthralgias
If getting an elective splenectomy, when should you get the pneumococcal vaccine?
2 weeks before
GBS linked to what vaccines?
Flu (1970s)
Tdap?
COVID
Is there an indication for Tdap as part of an outbreak response?
No
What type of vaccine is vaccinia?
Live vaccine- smallpox
Who should be vaccinated for smallpox in a routine non-emergency? How often?
- Lab workers who work with vaccinia or orthopox viruses that infect humans (every 3 years)
Those who administer smallpox vaccine to others (every 10 years)
How long should you wait to do a TST after smallpox vaccine
1 month
What is a concern for vaccinia vacine?
Live vaccine can cause the virus to be transmitted to close contacts
What vaccine are the follow considerations for close contacts for:
- cardiac disease
- eye disease with topical steroids
- immunodeficiency disorders
- eczema
- pregnancy
- breastfeeding mothers
- infants
- 3 or more cardiac risk factors (hypertension, diabetes, high cholesterol)
- latex sensitivity
Vaccinia vaccine
What are the side effects of the vaccinia vaccine? Note, most people will have at least 1 adverse event
Rash
Inadvertent ocular inoculation
myocarditis
This live vaccine can cause a rash in immunocompromised and potentially transmit disease to others
Varicella
Proof of immunity: varicella
1) written 2-dose vax record
2) lab evidence
3) physician verified dx
Indications for meningococcal vaccine
- asplenia
- travel to countries with endemic meningococcal disease
- lab employees with exposure
Goals of the HCP vax program
1) achieve high rates of immunization
2) Devise and implement specific vaccine strategies
3) provide education about vaccine
4) Justify the cost
Can Hep B vaccine be frozen?
No
Do HCP born before 1957 have to provide lab evidence of disease?
Yes- all HCP must have documented immunity against measles
Is there a booster for polio?
Yes, booster recommended for high-risk
What vaccines should be frozen?
Vaccinia
Powdered varicella vaccine
Recommended vaccines for healthcare workers
Hep B
Influenza
MMR
Tdap
Type of temperature monitoring device recommended by CDC
Digital Data Logger
Way to measure temperature in vaccine fridge
Buffered temp probe with buffer (glycol, glass beads, sand, teflon)
difference between expiration date and beyond use dates on vaccines
Expiration - final day that vaccine can be used
Beyond use- last date or time that vaccine can be safely used after it was moved
When to discard multi-dose vials
after max number of doses drawn, exp date, or 28 days after first puncture, whichever comes first
What is the maximum number of transport + clinic hours for a vaccine?
8 hours
Vaccine storage requirements
- original packaging, , labeled separate containers
- middle shelf away from walls/ ceiling/ floor/ door
- temp stable area
- store with diluent
- leave room for circulation
What should be used to keep vaccines cold during transport?
Phase change materials
What diseases are standard precautions the only preventative measure?
CMV (Std)
HCV (std)
Parvovirus B19 (droplet)
TB (airborne)
What vaccines are contraindicated for pregnant women?
HPV
Live flu (LAIV)
MMR
Varicella
Zoster
What vaccines are recommended during pregnancy?
inactivated flu
Hep A if indicated
Hep B sometimes
Tdap
What is the concern if a pregnant woman cares for an immunocompromised patient with chronic anemia?
Parvovirus B19
What diseases can pregnant women take PEP chemoprophylaxis for?
N. meningitidis
Syphillis
HIV
What birth defects can varicella cause?
- malformations (skin, limb, CNS, eye)
Requirements for volunteers, contract workers, etc..
1) review medical eval and immunizations programs for facility
2) Process for management of job-related illnesses and exposures, including work restrictions
3) Counseling services related to exposure
4) maintenance and confidentiality of health records
What education should be offered to nonemployee HCP
- IP policies and procedures and their locations
- chain of infection/ modes of transmission
- BBP exposure prevention and plan
- TB education and plan
- HH
- PPE
- Fed, state, and local regulations
- process to report events, near misses, and unsafe work practices
Actions taken to decrease the potential impact of a sitution
mitigation
measures taken before an event that help prepare an individual, facility, or community to respond to the emergency
preparedness
Intervention undertaken in response to a known or suspected event
Response
Intervention implemented after the emergency has been declared over
Recovery
Water needed for emergency management
25 gal a day for pt care
Control to reduce the likelihood of an exposure by altering the manner in which the task is accomplished
administrative and work practice controls
Example- training HCP on safer technique to recap needle
Clinical symptom primary TB
Erythema nodosum
Fever
Cough
Gohn complex
Parts of the TB control plan
1) risk assessment
2) Administrative controls (methods to ID pts and get to AII)
3) Environmental Controls
4) Respiratory protection
Leading cause of NTM in the U.S.
Mycobacterium avium complex
Bacteria that cause pneumonia most often in older adults (65+)
Strep pneumo
Klebsiella pneumo
Pseudomanas
Legionella
How long should chemoprophylaxis continue during a flu outbreak?
at least 14 days, 7 days after the last case
What vaccines are recommended for older adults (as routine vax)
Flu (high antigen)
COVID
TDAP (if never had one before) and TD every 10 years
Pneumo
Zoster
Most common HAI in neonates
BSIs
Pneumonia
Standard Precaution Components
- Hand hygiene
- Appropriate use of PPE
- Respiratory hygiene/ cough etiquette
- Proper placement of patients
- Safe injection practices
- Disinfection and sterilization of reusable medical equipment
5 moments of hand hygiene
1) before touching a patient
2) before a clean or aseptic procedure
3) after body fluid exposure risk
4) after touching a patient
5) after touching patient surroundings
Are ambulatory centers required to use precautions for MDROs?
No, Due to the shorter stays and typically lower intensity of care, the risk of spread of MDROs in outpatient facilities is generally reduced and as a result, many ambulatory facilities may choose to not use precautions
How much space should there be around furniture/ procedure tables in ambulatory centers?
3 feet
Recognize antigens, differentiate into plasma cells that secrete antibodies (immunoglobulins), which inactivate microorganisms alone or in combination with complement phagocytes
B-lymphocyte
Help or suppress cell function, may also be cytotoxic, killing target cells that express foreign antigens
T-lymphocytes
Immune cells that help fight bacteria and fungi, migrate toward site of infection (chemotaxis), ingest and kill microbes
phagocytes (including neutrophils, eosinophils, basophils, monocytes, and macrophages)
What is are the precautions for a TB autopsy?
N95
What patients are at increased risk for fungal infections?
- Leukemia
- Solid tumors and leukopenia
- Bone marrow transplant
- Injection drug users
- Pts with intra-abdominal or cardiothoracic surgery
- Burn victims
- Premature/ low birth weight infants
Do antimicrobials in multidose vials protect against:
Bacteria
Viruses
Bacteria- yes
Viruses- no
What do you look for during an antibiotic time out? When should the timeout occur?
- Correct dose
- Duration of therapy
- Indication for treatment
24-48 hours after culture results
How far must sterile items be stored from the ceiling or sprinklers?
18 inches
How far must sterile items be stored from the floor?
8-10 inches
What type of pressure is needed in a sterile storage room
positive
How many ACH for sterile storage rooms?
at least 4, but 10 preferred
Temperature of sterile storage room
65-72F
What infections require mothers to withhold breastmilk?
HIV
HSV on breast
WNV
Human T-cell lymphotropic virus type I or II
Active TB (but can pump and give milk to baby if treatment not contraindicated)
Humidity sterile storage
35-75%
ACH/ pressure for decontamination/ contaminated storage area
Negative, 10 ACH
Portals of entry for CVCs
- Stopcocks for medicine injection (cap when not in use, closed systems preferred)
- Admin IV infusions
- Collection of blood samples
Which type of alcohol has greater activity against:
Bacteria
Viruses
Bacteria: isopropyl alcohol
Viruses: ethyl alcohol
Types of antiseptics
- Alcohol
- Chlorohexidine
- Chlorine
- Hexachlorophene
- Iodine
- Chloroxylenol (PCMX)
- Quat ammonium
Indications for hand washing
- visibly soiled
- Before eating
- Before preparing food
- after using the bathroom
- exposed to spire-forming organisms
Per fire code, what is the minimum width of the corridor with hand sanitizer dispensers, and how far apart must they be?
- 6 feet
- 4 feet apart
What antiseptic agents have persistent activity against bacteria?
CHG
Iodophers
Process for surgical hand antisepsis
remove jewelry, clean nails, wash hands and arms
How to improve HH?
- administrative support
- convenient and acceptable products/ dispensers
- monitoring and feedback
- role modeling- excellent HH
- Motivational/ incentive programs
What is required for HH by the TJC?
Education, monitoring, and feedback
Type of hand hygiene monitoring with the following pros:
Real-time corrections
- assess HH technique and durations
- ID reasons for missed HH opportunities
- Pts and families can observe and notify
Direct Observation
Type of hand hygiene monitoring with the following pros:
- Always in place
- Capture all HCP and visitors
- Minimized hawthorne effect
- Not time consuming
- Just-in-time reminders
- Consistent
Automated monitoring (sensing devices)
Type of hand hygiene monitoring with the following pros:
- Less time and resources
- All the time
- Better for difficult to observe areas, like the OR
Product volume monitoring
Type of hand hygiene monitoring with the following cons:
- Time consuming
- Difficult to recruit observers
- Variability of observers
- Hawthorne effect
- Biased to weekday/ day shifts, captures small portion of HCP
Direct observation
Type of hand hygiene monitoring with the following cons:
- $$
- HCP need special badge
- Rely on entry/ exit but may not detect other HH moments
- No immediate feedback
- Unpopular with HCP
Automated Monitoring
Type of hand hygiene monitoring with the following cons:
- Need accurate supply info at the unit level
- documenting data can delay distribution
- cannot assess technique or duration
- cannot discern HCP/ visitor use
Product volume monitoring
Calculations for HH through product volume monitoring
Volume used (specific product) / 1000 pt days
Reasons for poor HH adherence
- Lack of knowledge
- Increased demands with less time
- Irritated, dry hands
- Lack of soap and paper towels
- Inaccessible sinks
- Shortage of sinks
- Belief that wearing gloves replace need tor HH
- Lack of administrative sanctions
This ruling protects employees from unprotected contact with patient blood, body fluid, secretions, excretions, mucous membranes, and non-intact skin
OSHA Bloodborne Pathogen Standard (1991)
What is needed for success of a BBP program
- administrative support
- Education
- Policies and procedures
- Institutional culture
When to use gloves under standard precautions
Touching:
- mucous membranes
- non-intact skin
- blood
- body fluids
- secretions
- excretions
- contaminated objects
Examples of safe work practices
- check PPE before contact (so not re-adjusting)
- Position pt so sprays/ splatters –> away from HCP
- Barrier for resuscitation
What patients should be prioritized if single room is not available?
Pts with poor hygiene/ etiquette or increased risk for severe outcomes
Standard precautions
- Hand hygiene
- PPE
- Resp/ cough etiquette
- Safe work practices
- Env cleaning
- Safe injection practices
- Patient placement
What HCP should be restricted from working with patients on airborne precautions?
- immunocompromised
- pregnant
- Susceptible
What policies and procedures are needed regarding transmission based precautions?
- Chemoprophylaxis
- PEP
- Immunization
- TB screening for HCP
When to use contact precautions
Heavy environmental contamination
Diseases transmitted by contact with pt or pt env
PPE for contact precautions
Gown and gloves
What PPE should env where for cleaning contact precautions rooms.
Gown and gloves
What should be used for terminal cleaning of contact precaution rooms
HP or UV light
Distance between patients for droplet precautions
6 ft
Type of masks required for:
TB
Smallpox
Measles
Chickenpox
TB- N95
Smallpox - N95
Measles- N95 or surgical mask (if not immune)
Chickenpox- N95 or surgical mask (if not immune)
How many ACH for protective env
12 ACH
Administrative measures for MDRO control
- implement active surveillance culturing (based on risk assessment)
- activate computer alerts for colonized patients
- provide accessible and frequent sinks/ abhr dispensers
- maintain nurse staffing levels
- enforce HH adherence
- enforce contact precaution adherence (including cohorting pts)
Surveillance for MDROs
- monitor microbiology isolates
- calculate incidence/ infection rates
Use molecular typing for investigating outbreaks - active culture surveillance
Planning for active surveillance cultures
- provide additional personnel to obtain cultures and additional lab personnel to process cultures
- ensure turnaround time for screening results
- monitor adherence to contact precautions
- provide mechanism for communicating results to HCP
- measure outcomes to evaluate the effectiveness of active surveillance cultures and contact precautions
Control methods for MDROs
- Administrative measures/ adherence monitoring
- MDRO education
- Judicious use of antimicrobials
- Surveillance
- Isolation precautions
- Environmental measures
- Decolonization
How long MDRO patients are on contact precautions
Duration of hospital stay
Antimicrobial agents that may be targeted for MDRO control
- vancomycin
- third generation cephalosporins (including for ESBLs)
- anti-anaerobic agents VRE
- quinolones
- carbepenems
If single rooms/ cohorting patients with the same MDRO is ot possible, who should room with a patient with an MDRO
pts at low risk of getting the MDRO (lower acuity), have short lengths of stay, and are not associate with adverse outcomes
How long after surgery should you use sterile gloves?
24 hours
How long after surgery should you use sterile dressings?
24-48 hours
When to use clean technique
- wound care
- peripheral venous catheters
- respiratory suctioning
Pressure for OR
positive
Type of gloves and type of technique for wound cleaning
Clean gloves, clean technique
Type of gloves and type of technique for routine dressing changes without debidement
Clean gloves, clean technique
Type of gloves and type of technique for dressing change with mechanical, chemical, or enzymatic debridement
clean gloves, clean technique
Type of gloves and type of technique for dressing change with sharp, conservative bedside debridement
sterile gloves, sterile technique
Type of gloves and type of technique for central line dressing change
Sterile gloves, sterile technique
Type of gloves and type of technique for tracheal suctioning when the tracheal suction is not within a closed sheath
Sterile gloves, clean technique
Type of gloves and type of technique for tracheostomy care or suctioning within a closed sheath
Clean gloves, clean technique
What are the aspects of aseptic technique
- barriers
- patient and equipment preparation
- environmental controls
- contact guidelines
process for keeping away disease producing microorganisms
asepsis
Technique to prevent the transfer of any organisms from one person to another or from one body site to another
Surgical asepsis/ sterile technique
Technique to practice interventions that reduce the numbers of microorganisms to prevent and reduce transmission risk from one person (or place) to another
Medical asepsis/ clean technique
Timeline to follow superficial SSI
30 days
Timeline to follow secondary incisional SSI
30 days
Surgeries that require 90 day follow up for deep incisional or organ space SSI
- Breast surgery
- Cardiac surgery
- Coronary artery bypass graft
- Craniotomy
- Spinal fusion
- Open reduction of fracture
- Herniorrhaphy
- Hip prosthesis
- Knee prosthesis
- Pacemaker surgery
- Peripheral vascular bypass surgery
- Ventricular shunt
Signs/ symptoms deep tissue/ organ space infections
- abscess
- deep incisional (primary/ secondary)
- osteomyletis
- -itis of the surrounding organ or space (ie endocarditis)
- arterial/ venous infection
- intrabdominal, not specified elsewhere
- other infections of lower respiratory system
NHSN Superficial SSI definition
- DOE within 30 days of operative procedure
- AND involves only skin and subcutaneous tissue of the incision
- AND pt has at least one of the following:
1) purulent drainage from the incision
2) organism ID’d from superficial site by culture or non-culture
3) Dx of SSI
4) Superficial incision deliberately opened by HCP and further testing not performed AND patient has one of the following:
a) localized pain
b) tenderness
c) localized swelling
d) erythema/ or heat
NHSN deep incisional SSI definition
- DOE within 30 or 90 days of procedure
- AND involves deep soft tissues of incision (facial/ muscle layers)
- AND patient has least one of the following
1) purulent drainage from deep incision
2) Abscess or other evidence of infection involving deep incision detected in fross anatomical or histopathological exam or imaging test
3) Deep incision spontaneously dehices (bursts open) or is deliberately opened or aspirated
a) AND organism from deep soft tissue ID’d from culture/ non-culture
b) AND patient as either fever or localized pain and tenderness
NHSN organ/ space SSI definition
- DOE- withing 30 or 90 days of the procedure
- AND involves any part of the body deeper than the facial/ muscle layers
- AND patient has at least on of the following:
1) Purulent drainage from drain placed into organ/ space
2) Organisms ID’d from fluid or tissue in organ/ space by culture or non-culture test
3) An abscess or other evidence of infection involving the organ/ space detected on gross anatomical or histopathological exam, or imaging test evidence suggestive of infection - AND infection in an organ/ space (ie osteomyletis, Pharyngitis, meningitis, joint or bursa infection, disc space infection, etc.)
What information is collected for each operative procedure?
- wound class
- ASA score
- Trauma
- Closure technique
- Duration of procedure
- General anesthesia?
- emergency procedure?
- Diabetes mellitus
Uninfected, operative wound in which no inflammation is encountered and the respiratory, ailmentary, genital, or uninfected urinary tract is not entered. Primarily closed, and if necessary, drained with closed drainage.
Clean wounds
Wounds class of operative incisional wounds that follow nonpenetrating (blunt) trauma
Clean wound
Operative wound in which the respiratory, ailmentary, genital, or urinary tracts are entered under controlled conditions and without unusual contamination.
Clean contaminated wound
Wound class for operations of biliary tract (ie chloecystectomy)
Clean contaminated wound
Wound class for operations of the appendix (appendectomy)
Clean contaminated wound
Wound class for operations of the vagina (hysterectomy)
Clean contaminated
Wound class for operations of the oropharynx (tonsilectomy)
Clean contaminated
Open, fresh, accidental wounds. Operations with major breaks in sterile technique or gross spillage from the GI tract, and incisions in which acute, nonpurulent inflammation is encountered.
Contaminated
Wound class of open cardiac massage
Contaminated
Wound class perforated bowel
Contaminated
Old traumatic wounds with retained devitalized tissue and those that involve existing clinical infection or perforated viscera.
Dirty/ infected
Wound class: wound with purulence/ existing clinical infection
Dirty/ infected
Wound class: wound with perforated viscera
Dirty/ infected
Wound class: open traumatic wounds >4 hours
Dirty/ infected
Wound class: wound with devitalized tissue
Dirty/ infected
Wound class: wound with penetrating injuries > 4 hours
Dirty/ infected
Wound class: Wound with acute, nonpurulent inflammation
Contaminated
Wound class: wound with gross (any) spillage from the GI tract (bile)
Contaminated
Wound class: wound with infarcted or necrotic bowel (non-perforated)
Contaminated
Wound class: open, fresh, accidental wounds
Contaminated
Wound class: major break in sterile technique
Contaminated
Would class: operation entered the respiratory, GI, or genitourniary tract
Clean/ contaminated
Wound from operation that did not enter the resp, GI, or genitourniary tract and shows no sign of infection
Clean
ASA score: The patient was previously healthy and fit
1
ASA score: current smoker
2
ASA score: social alcohol drinker
2
ASA score: pregnant
2
ASA score: obesity
2
ASA score: well-controlled diabetes melitus
2
ASA score: well controlled hypertension
2
ASA score: mild lung disease
2
ASA score: the patient has mild systemic controlled disease
2
ASA score: the patient has severe, but not incapacitating systemic disease
3
ASA score: patient has substanive functional limitations
3
ASA score: patient has one or more moderate to severe disease
3
ASA score: poorly controlled diabetes
3
ASA score: poorly controlled hypertension
3
ASA score: COPD
3
ASA score: morbid obesity
3
ASA score: active hepatitis
3
ASA score: alcohol dependence
3
ASA score: implanted pacemaker
3
ASA score: moderate reduction of ejection fraction (systolic heart failure)
3
ASA score: end-stage renal disease undergoing regular dialysis
3
ASA score: myocardial infarction (heart attack) > 3 months ago
3
ASA score: CVA (cerebrovascular accident or stroke) > 3 months ago
3
ASA score: transient ischemic attack (TIA AKA mini-stroke) > 3 months ago
3
ASA score: coronary artery disease (CAD) or stent > 3 months ago
3
ASA score: patient has incapacitating systemic disease
4
ASA score: recent myocardial infarction (heart attack) in last 3 months
4
ASA score: CVA (cerebrovascular accident or stroke) in last 3 months ago
4
ASA score: transient ischemic attack (TIA AKA mini-stroke) within 3 months
4
ASA score: coronary artery disease (CAD) or stent within 3 months
4
ASA score: ongoing cardiac ischemia or severe valve dysfunction
4
ASA score: severe reduction of ejection fraction (systolic heart failure)
4
ASA score: sepsis
4
ASA score: Disseminated intravascular coagulation (DIC) (blood clots)
4
ASA score: ARDS (acute respiratory distress syndrome)
4
ASA score: end stage renal disease (ESRD)
4
ASA score: the patient is moribund and not expected to survive 24 hours
5
ASA score: ruptured abdominal/ thoracic aneurysm
5
ASA score: massive trauma
5
ASA score: intracranial bleed with mass effect
5
ASA score: ischemic bowel in the face of significant cardiac pathology (blood flow to bowel completely blocked)
5
ASA score: multiple organ/ system dysfunction
5
Closure technique: closure of skin during original surgery (any portion of incision by any manner, even if there are drains)
Primary closure
Closure technique: closure of wound in way that leaves the skin completely open following surgery (may be packed with guaze)
Non-primary closure
Closure technique: laparotomy in which the incision was closed to the level of the deep tissue layers, sometimes called the fascial layers, but the skin level was left open
non-primary closure
Closure technique: the abdomen was left completely open after the surgery (open abdomen)
non-primary closure
What is the most common HAI - making up 32% of HAIs?
Pneumonia
Infection present day of admission (day 1), 2 days before admission, and 1 calendar day after admission
Present on Admission
How long must a patient be on mechanical ventilation for VAP?
> 2 calendar days
Definition PNU-2 (Pneumonia with common bacterial, fungal, or viral pathogens
- Imaging test evidence
- AND Clinically defined signs and symptoms
- AND specific lab findings
Definition PNU-1 (pneumonia based on clinical findings
- imaging test evidence
- AND clinically defined signs and symptoms
What would show up on test imaging for VAP?
- infiltrate (substance that’s denser than air, such as blood, pus, or protein, that lingers in the lungs)
- consolidation (fluid replaces air in lungs)
- cavitation (gas-filled area in the center of a lung nodule)
- pneumatoceles (air filled cysts)
How many chest images does a patient with underlying disease need to meet NHSN’s VAP definition? A healthy patient?
2 for patient with underlying disease
1 for healthy patient
NHSN- need at least one of these key symptoms for VAP classification in people > 1 year
1) Fever
2) Leukopenia or leukocytosis (>1 year, 12k)
3) Altered mental status with no other cause
NHSN- Need at least two of the following symptoms for VAP in anyone >1 (in addition to fever, leukopenia or leukcytosis, or altered mental status) in people >1 year
- new or worsening sputum, increased secretions or suctioning
- new or worsening cough, dypsnea, tachpnea
- rales or bronchial breath sounds
- worsening gas exchange (ie increased O2 demand)
NHSN: If child is 1 year old or less, they need to have worsening air exchanged to be classified with VAP. How does that present?
pulse oximetry <94%
increased O2 requirement
NHSN, what are the symptoms for children <=1 year for VAP (need 3)
- temp instability
- leukopenia or leukocytosis (15k in <=1 year old)
- new or change to sputum, increased resp secretions or suctioning
- apnea, tachypnea, nasal flaring
- wheezing, rales, rhonchi
- cough
- bradycardia or tachycardia
If these organisms are detected in respiratory secretions or tissue, and the individual has symptoms and chest imagining findings, they person has VAP per NHSN
- Virus
- Bordetella pertussis
- Legionella pneumophila
- Chlamydia pneumoniae
- Mycoplasma pneumoniae
What tests for legionella pneumonphila fall under the NHSN defintion for VAP
- culture or non-culture based micro test
- fourfold rise in serogroup 1 antibody titer to >=1:128 by indirect IFA
- Detection in urine by RIA or EIA
NHSN: what are the pathogen exclusions for VAP unless they are ID’d from lung tissue or pleural fluid
- Candida species or yeast
- Coagulase-negative staph
- Enterococcus
Unless ID’d from lung tissue or pleural fluid, these community associated fungal pathogens are excluded from the NHSN VAP definition, why?
- cryptococcus
- histoplasma
- coccidioides
- paracoccidiodes
- blastomyces
- pneumocystis
They rarely cause or are not known to cause HAIs
Is sputum a minimally contaminated LRT specimen?
NO
What are acceptable specimens for pneumo testing?
- bronchoalveolar lavage (BAL)
- protected specimen brushing
- endotrachael aspirate
NHSN: HAI VAP: Where do organisms need to be ID’d from?
Blood/ pleural fluid
NHSN: HAI pneumo histopathlogical lab results
- abscess formation or consolidation
- lung parenchyma invasion by fungi
NHSN: VAP: specimen sources for positive quantitaive culture
- minimally contaminated LRT specimen (BAL, protected specimen brushing, or endotracheal aspirate)
- lung culture
NHSN: VAP >= _________% BAL-obtained cells contain intracellular bacteria on direct microscope examination
5%
How do symptoms of immunocompromised people differ for the definition of NHSN VAP?
Immunocompetent need 1 primary symptom (fever, leukopenia or leukocytosis, or altered mental status) and at least 2 other resp symptoms and imaging
Immunocompromised people need just one symptom (primary symptoms or resp syptoms) and a lab (which can include candida or fungi)
Is physician DX enough to classify as VAP in NHSN?
No
What is the rate equation for VAP in NHSN?
of VAP in location/ # ventilator days in location *1000
How long does a central line have to be in to be considered a CLABSI in NHSN?
at least 2 days, so may be a CLABSI on or after the 3rd calendar day
Intravascular catheter that terminates at or close to the heart or in one of the great vessels used for infusion, withdrawal of blood, or hemodynamic monitoring
Central line
Is ECMO considered a central line?
No
Are peripheral IVs or midlines considered central lines?
No
Are ventricular assist devices considered central lines?
No
What are the 3 types of central lines?
- Temporary central line (non-tunneled, non-implanted catheter)
- Permanent central line (tunneled or implantable catheter)
- Umbilical catheter
What are the common commensals for CLABSIs?
- Diphtheroids
- Bacilus spp.
- Propionibacterium
- Coagulase-negative staph
- Virdans group strep
- aerococcus
- micrococcus
- rhodococcus
LCBI 1
- recognized bacterial or fungal pathogen ID’d from at least 1 culture and organism ID’d in blood is not related to another site
Are symptoms required for an LCBI 1?
No (related to pathogens, not common comensals)
What are the parameters for an LCBI 2 if common commensals are detected?
- @ least 1 symptoms (fever or hypotension)
- AND organisms not related to infection at another site
- AND same common commensal ID’d from 2+ blood specimens collected on separate occasions (within 2 days - same or consecutive days)
What are the different CLABSI symptoms for LCBI (common commensal in neonates and infants)?
- Fever
- Hypothermia
- apnea
- Bradycardia
Other are the same as LCBI 2
What does LCBI stand for?
Lab-confirmed Bloodstream Infection
Generally, what are the rules to be defined as a mucosal barrier injury-lab-confirmed bloodstream infection?
LCBI
AND allogenic HSCT recipient in past year with GI GVHD or massive amounts of diarrhea OR neutropenic
Commensals include viridans group strep or rothia spp
SIR
observed HAIs/ predicted HAIs
Equation for CLABSI rate
CLABSIs for location/ # central line days for that location *1000
Equation for Central line DUR
central line days for location/ pt days for that location
Equation for central line SUR
observed central line days/ # predicted central line days
What are some complications of CAUTIs?
- cystitis
- pylenoephritis
- gram negative bacteremia
- endocarditis
- vetebral osteomyelitis
- septic arthritis
- endopthalmitis
- meningitis
Timeline for a healthcare associated infection, example if admitted to hospital on June 3
Date of event occurs on or after third calendar day of admission to inpatient location (where the date of admission is day 1)
Example: admitted to the hospital on the June 3
June 1- June 4 - POA
June 5 and later- HAI
UTI where indwelling catheter in place for more than 2 consecutive days in an inpatient location and the catheter is in place on the DOE or the day before
CAUTI
Drainage tube inserted into urinary bladder through the urethra, left in place, and connected to a drainage bag
Foley catheter
What devices are not included in CAUTI rates?
- condom caths
- straight in and out caths
- nephrostemy tubes
- ileoconduits
- suprapubic caths
Describe a catheter associated symptomatic UTI (SUTI)
- Indwelling catheter in place 3+ days and present any portion of DOE or removed day before DOE
- AND pt has signs/ symptoms
- AND pt has positive urine culture (no more than 2 species, @ least 1 is >=10^5 CFU/mL)
Signs/ symptoms of CAUTI (need 1)
- Fever
- Suparpubic tenderness
- costovetebreal angle pain or tenderness
CANNOT BE USED WHEN CATH IN PLACE:
- urinary urgency
- urinary frequency
- dysuria (burning while urinating)
NHSN definition, non-catheter associated UTI
No cath or cath in place <2 days
- signs/ symptoms of UTI
- Urine culture with no more than 2 species and at least 1 bacteria is >=10^5 CFU/ mL
What are the additional symptoms for UTI/ CAUTIs in kids < 1 year old
- Fever
- Hypothermai
- Apnea
- Bradycardia
- Lethargy
- Vom
- Suprapubic tenderness
10^5
100,000
If someone has a urine culture with <2 species and 1 bacteria is >100,000 CFU, mL, but they are asymptomatic, could they have a CAUTI?
Yes, but they would need a matching organism ID’d in a blood specimen
Do fungi meet the case definition for CAUTIs?
No, bacteria only
Do parasites meet the case def for CAUTIs?
No, bacteria only
Equation for CAUTI rate
cautis/ # cath days *1000
Equation for DUR
of urinary cath days/ # patient days *1000
MRSA- staph aureus specimen that tests positive for ____ resistance, _____ resistance, or _____ resistance via susceptibility, PCR or other methods
oxacillin-resistance, cefoxitin- resistance, or methicillin-resistance
Cefoxitin
2nd generation cephalosporin
Ceftazidime
3rd gen cephalosporin
Cefotaxime
3rd generation cephalosporin
Cefepime
4th generation cephalosporin
CephR-Klebsiella
Resistant to Ceftazidime, cefotaxime, and cefepime
What are the genes that code for resistance to carbepenems?
KPC
NDM
CIM
IMP
Oxa-48
What are MDRO-Acinetobacter spp resistant to?
@ least one of each:
Aminoclycoside
Carbapenems
Fluoroquinolones
LabID even specimen collected >3 days after admission to the facility (on or after day 4)
Healthcare facility onset
LabID event specimen collected in outpatient location or an inpatient location <=3 days after admission to the facility (days 1-3)
Community onset
LabID event collected from a patient who was discharged from the facility <=4 weeks prior to the date current stool specimen was collected
Community-onset Healthcare facility associated
When is a LabID event considered recurrent?
If it’s been >14 days and <8 weeks or 56 days
What is the leading cause of death from infection in the hospitalized patient?
Pneumonia
What are the parameters for healthcare associated pneumo?
- acute care hosp for 2+ days within 90 days of infection
- resided in nursing home or LTC
- Received IV antibiotics, chemo, or wound care within 30 days
- attended hosp or hemodialysis clinic
How long does someone have to be in the hospital to be considered a hospital-acquired pneumonia case/
at least 48 hours
Most common organisms CAP
- S pneumo
- S aureus
- H influenzae
- M orexellacatarhallis
What are the most common causes of atypical CAP?
- Legionella
- Chlamydia penumoniae
- Mycoplasma pneumoniae
- enterobacter
Risk factors for S. aureus pneumo
- end stage renal disease
- IV drug s
- prior flu
- prior antibiotic use with quinolones
How does MRSA pneumo impact neutrophils
Causes severe neutropenia
Risks for HAP/ HCAP
- antimicrobials in past 90 days
- hosp 5+ days
- high freq MDROs in community
- immunosupressed
CAP quality measures from the TJC
- blood culture within 24 hours and before antibiotics
- antibiotic timing
- antibiotic selection
- pneumococcal vax
- influenza vax
- smoking cessation counseling
Resp therapy equipment maintenance guidance
- only change circuit when soiled or malfunctioning
- drain and discard condensate
- sterile water for bubbling humidifiers
- only filter suspected TB
Prevention for HAP, HCP, and VAP
- flu and pneumo vax
- HH & glove use
- Resp therapy equip maintenance
- Avoid endotracheal intubation
- selective oral decontamination
- subglottic secretion drainage
- Iso pts with resistant organisms
- reduce nasogastric tubes
- start enteral feeding 24-48 hours after intubation
- ventilator bundle
Why are vascular access devices used to access the vascular system?
- hemodynamic monitoring
- admin medication
- infusions
- blood sampling
- dialysis
Short term or long term: peripheral access device
Short term
Short term or long term: midline catheter
Short term
Short term or long term: PICC line
Long term
Short term or long term: Tunneled CVAD
Long-Term
Short term or long term: Port
Long-term
Short term or long term: Non-tunneled percutaneous
Short-term
Length time for peripheral IV
<5 days
If UV guided up to 14 days
Length of time: midline cath
<=14 days
Length of time: non-tunneled intravenous device
<= 14 days
When is midline preferred to PICC?
<=14 days
When is a non-tunneled intravenous device preferred to a PICC?
<=14 days in critically ill patients
Timeline for PICC line
6+ days (weeks - months)
Length of time for tunneled intravenous device
> =15 days
What type of CVC is preferred for >=31 days
Implanted port
Can you administer vesicants in a peripheral access device?
No, not a central line, does not terminate in heart
Can Midline catheters accommodate vesicants?
No
What CVCs can accommodate irritants and vesicants?
- PICC lines
- Percutaneous short-term CVADs
- Tunneled long-term CVADs
- Implanted ports
CVC used for ongoing, high frequency access and can be accessed for months before requiring replacement
Tunneled
CVC used for temporary central access in critical and inpactient acute care setting
Non-tunneled
Complications of PICCS
- localized/ central infection
- thrombosis
- mechanical failure
Complications of implantable device insertion
- Catheter embolism
- malposition
- pneumothorax
- thrombosis
Where do CVCs terminate?
- Superior vena cava
- cavoatrial junction
When are cuffs present on catheters?
present on tunneled, not on non-tunneled
How are ports accessed?
Non-coring huber needle
What catheter has the lowest levels of BSI?
PICCs and Implanted ports
Coating on CVC to prevent colonization
- minocycline-rifampin
- chlorohexidine-silver sulfadizine
- platinum/ silver
Top microorganisms that cause CLABSIs
skin microbes:
- coagulase negative staph
- staph aureus
- enterococcus facalius
- klebsiella spp/
- candida albicans
= enterococus faceium
What is the source of most endemic CLABSIs?
Contamination of VAD
What is the source of most epidemic CLABSIs?
contamination of infusate
Pathology of BSI
- skin organisms –> percutaneous –> blood during insertion or days following
- Microbes contaminate catheter hub and lumen when catheter inserted
- Contaminated fluids
- another remote source of infection (not as common)
What size drape does a peripheral arterial cannulation require?
Small, sterile drape
All other lines require large, sterile full body drapes
How often to change wound dressing and gauze over central lines
Gauze- while wound draining, change every 2 days
Polyurethane film dressing- every 7 days
Are add on systems to central lines recommended?
No
How often should central line add-one be replacd?
Every 96 hours
How often should parenteral nutrition be changed?
not to exceed 24 hours
How often should blood products/ lipid emulsions be changed?
Lipid- 12 hours
generally 12-24 hours
What personal hygiene recommendation do they make for skin decolinization for people with central lines?
Chlorohexidine bathing
Are topical antimicrobials recommended for patients with central lines?
No, only for hemodialysis catheter exit sites
What are the VADA-BSI measures if the bundles and basic measures are not working?
- antiseptic/ antimicrobial impregnanted catheters
- chlorohexidine dressings
- antiseptic containing needleless connectors
- antimicrobial locks solution for CVADs
Who is antibiotic lock solution best suited for?
- long-term hemodialysis with limited venous access
- history recurrent BSIs
- High risk - ie prosthetic heart valve
Maximum dwell time to Antibiotic lock solution (ALS)
48 hours
What ALS antibiotic is best for a staph aureus infection?
Cefazolin
What ALS antibiotic is best for MRSA?
Vancomycin
What ALS antibiotic is best for gram-negative bacteria
Ceftazidime, gentamicin, ciprofloxacin
What ALS antibiotic is best for enterococcus?
ampicillin
If resistant- vancomycin
What ALS solution is best for mixes of gram positive and gram netative?
Ehtanol
prophylaxis may be used during hemodialysis to prevent _______
Thrombolysis
Antisepsis for neonates and infants
iodine, need to remove after asepsis
When to use chlorhexidine-gluconate impregnated sponge for catheters?
Oncology patients
General: management of short-term CVAD with VADA-BSI (fever/ inflammation/ staph bacteremia/ candidemia)?
Culture and remove
Replace in a new site if needed
General management of long-term CVAD with VADA -BSI
do not always need to remove, but remove when:
- persistent exit site infection
- tunnel infected
- endocarditis, septic thrombosis, or septic pulmonary emboli
- Most organisms other than coagulase-negative staph and enterococcus
A patient has a CLABSI from S. aureus, and they were treated with antibitoics and is now feeling better and symptoms appear to have resolved. Should the CVAD be removed?
Yes
What waterborne pathogens can cause BSI that require the CVC to be removed?
- Stentrophomonas
- Burkholderia
- Pseudomonas
Antibiotic for gram negative CLABSI
4th gen cephalosporin
carbapenem
Antimicrobial for candidemia
IV fluconazole
Is a midline a central line?
No
What organisms are most likely to contaminate the catheter hub?
- endogenous skin flora
- exogenous - HCW hands
What organisms are most likely to be introduced through the exit site?
- endogenous skin flora
- extrinsic organisms on HCW hands or contaminated disinfectant
Is contaminated infusate typical with short-term IVDs?
No
Infusion contaminated at the manufactuerer
Intrinsic contamination
Infusate contaminated during sterile compounding or on-site
Extrinsic
What catheters are responsible for most infections?
1) hemodialysis: non-cuffed
2) pulmonary artery catheter (Swan ganz)
3) Short-term non medicated CVCs
Swan Ganz or pulmonary artery catheter
Which is the lowest risk for skin antisepsis for VADA BSIS: 70% alcohol. 10% povidone iodine, or 2% chlorohexidine
2% chlorhexidine
Patient placement for CVC placement
tendelenburg for most
Supine- PICC / femoral
Most BSIs are of cutaneous origin that access the site ____________
extraluminally
What level disinfectant for environmental cleaning for surfaces infected with blood/ body fluids in dialysis center
Intermediate level
Reasons for infection in dialysis
- break in IP practices
- Bacterial seeding from remote site
- poor hygiene of care access arm
Types of dialysis infections
- access site infection
- bacteremia
- peritonitis
What organism is the biggest concern for fistulas?
Staph aureus
Infection prevention fistula
- patients wash access site daily and before hemodialysis
- Staff to practice HH, wear masks and gloves before accessing sites
- patients recognize infection sign/ symptoms
- antiseptic used - CHG + alcohol preferred
Decreasing risk for dialysis
- strict adherence to aseptic technique for ALL dialysis procedures
- Disinfection/ maintenance of equipment
- Well-trained staff
- Monitoring for bacterial contamination
- Patient education
- Active surveillance
What do you need to test for every 4 hours in dialysis?
Chloramine and chlorine
What is the CMS limit that requires disinfection within 48 hours for bacteria/ endotoxins?
Bacteria: action at 50 CFU/mL, limit 200
Endotoxin: action at 0.125 EU/ml, limit 2
What is the problem with bacteria and endotoxins in the dialysate?
fever
bacteremia
How often to test dialysis treated water and dialysate?
At least monthly
- weekly if new water system or change to system
Methods for dialysate/ treated water testing?
- membrane filter
- spread plate
NO calibrated loop
How often to disinfect mixing tank for bicarbonate in dialysis
Daily before first patient
What infections can result from improper cleaning and disinfection of priming waste?
Gram- negative rods
enterococcus
Most common pathogens in peritoneal dialysis
- staph aureus/ staph
- pseudomonas aeruginosa
- enterobacteriaceae
Most common sources dialysis infections
- patients skin or nares
- dialysate delivery system
- breaks in technique
- extrinsic or intrinsic contamination
- migration from GI tract
- vaginal leaks
Catheter placement peritoneal dialysis
- avoid skin folds and beltline
- easily accessible for pt inspection and care
- downward in pediatric patients
What is preferred for peritoneal dialysis: double cuff or single cuff?
double cuff
How often should hemodialysis patients receive Hep serology?
admission, then every 3-6 months
What to review when there is an increase in infection caused by water-associated gram-negative organisms or endotoxin-like reactions at the dialysis location?
- culture processed water and dialysate
- review cleaning and disinfection
- review multi-use vials processes
Steps after dialysis center sees positive HBsAg for first time
- report to HD
- Isolate
- did they get vax in last 30 days?
- follow up tests for confirmation of infection
- medical record review (eposures?)
Normal treatment for uncomplicated cystitis
nitrofuraton monohydrate/ macrocrystals (Macrobid)
or
TMP-SMX (bactrim)
What organisms typically causes epididymitis related to UTIs in males >35 years
E. coli
Pseudomonas
Symptoms of pyelonephritis
abrupt onset fever
unilateral costovertebral angle tenderness
Risks for pyelonephritis
- female
- sex
- new sex partner
- spermicide
- maternal history of UTI
- recent UTI
- Diabetes
- smoking
- incontenence
How to get a sample from a patient with an indwelling urinary catheter?
Sample port using aseptic technique, do NOT use leg bag
What is indicative of a contaminated urine sample?
3 or more species in the sample
Symptoms UTI in children
- fussy
- fever
- anoerexia
- emesis
- ab pain
- neonatal jaundice
- poor weight gain
- enuresis
- hematuria
Risk factors UTI in reproductive age female
- spermicide
- delayed postcoital micturition
- multiple sex partners
- more freq sex
Screening and treatment for UTIs in pregnant women
- screen at 12-16
- treat even if asymptomatic
- admit for pyelonephritis
- avoid TMP-SMX after 32 weeks of pregnancy
Should you treat asymptomatic UTIs in elderly patients?
No
What pathogens are responsible for UTIs in LTC males?
E. coli
Proteus morabilis
Treatment for complicated UTIs (males, children, diabetics with symptoms)
Fluroquinolones
What pathogens cause UTIs in diabetics?
E. coli
Klebsiella
Group B Strep
Most common HAI (correct)
UTIs
How do most CAUTIs in males happen?
intraluminal route from contaminated drainage bag
How do most CAUTIs in females happen?
transeurethral migration up extraluminal surface of catheter
Indications for indwelling unrinary catheters
- anatomic, urinary retention, bladder obstruction
- measure urinary output in critically ill patient
- perioperative use for certain surgeries
- assist in health open sacral or perineal wounds in incontenent pts
- improve comfort for end of life, pt preference
What position is best served to give catheter removal reminders?
nurses
What is the time limit for urinary catheter use in surgery?
<=48 hours
IPs role in preventing CAUTIs
- appropriate infrastructure to prevent CAUTI
- CAUTI surveillance
- education and training
- appropriate technique during catheter insertion
- appropriate management indwelling catheters
- accountability
- performance measures
What organisms commonly cause HAI UTIs?
E. coli
Enterobacteriaceae (pseudomonas, Serratia)
carotid endarterectomy
removes plaque in the coritid artery
Laminectomy
Removal of the roof of the spinal cord
Anoscope
examines anus and rectum
Thorascoscope
examines chest organs through small incision
arthroscope
examines joint through incision above knee
Colposcope
Examines cervix through vagina
Endoscopic retrograde cholangiopancreatography
combines X-rays with upper GI endoscopy to diagnose or treat problems with the bile and pancreatic ducts.
Enteroscopy
Used to examine your small intestines via your mouth or anus.
Proctoscope
examine the anal cavity, rectum, or sigmoid colon (just the rectum and colon)
Hysteroscope
examination of the inside of the uterus
Sigmoidoscope
shorter version of a colonoscopy, focusing on the rectum and the lower part of the colon
Mediastinoscope
examine the space between your lungs via an incision above your sternum.
thoractomy
surgical procedure that allows a surgeon to access the chest’s pleural space and thoracic organs, cut between the ribs
thorascope
examine your chest cavity and its contents (your lungs and the covering of the lungs) via an incision in your chest.
Chromoendoscope
technique that uses a specialized stain or dye on the lining of the intestine during an endoscopy procedure.
duodenoscope
flexible, lighted, hollow tube that doctors use to examine and treat issues in the pancreas and bile ducts
Reasons for outbreaks from endoscopy
- defective equipment
- inability to access elevator channels during cleaning and disinfection
- inadequate cleaning and disinfection
- contaminated automatic endoscope reprocessor (AER)
- Biolfilms in endoscope or AER
- Contaminated multidose vials, needles, y=syringes for anethesia
How often to discard endoscope detergent
After each use
What organisms have been associated with endoscopy outbreaks?
- Hep B
- Hep C
- CRE
- P. aeruginosa
- S. marcescens
- M. tb
What is the general manual parameters for HLD of endoscopes?
- > 2% glutaraldehyde at 25C, 20-90 minutes
- rinse with large amounts of water
When does cleaning the endoscope with brushes occur?
Before HLD
Difference between alcohol % for antisepsis versus in the endoscope rinse after disinfection.
Antisepsis: 60-95%
Disinfection rinse: 70-90%
IP for bronchoscopy
- immunizations (esp flu) and TB screening
- disposable caps/ valves
- screen for symptoms
IP for if someone has resp symptoms and is due for a bronchoscopy procedures
- push back date of procedure
- complete in AIIR
- PPE
- Thoroughly clean room before next patient
- allow enough time for airborne agents to dissipate
If the endoscope breaks the mucousal barrier, what level of disinfection is required?
Sterilization
Cleaning/ disinfection process for water bottle used to clean lens/ irrigation during procefure
- clean bottle and connecting tube with HLD at least daily
- Use only sterile water
MEC
Minimum effective concentration for disinfection
Who do reports need to go to if there is an outbreak related to endoscopy equipment?
- IP
- physician
- CDC
- FDA
- manufacturer
Outbreak response for endoscopy
- report
- remove and label the equipment after possible failure
- isolates
- env sampling- standard OB inv
- evaluate policies and procedures, technique of personnel, and handling of equipment
Endopthalmitis
Inflammation of intraoccular cavities
What are the common reservoirs for adenoviruses in opthalmology?
- HCP hands
- tears
- Contaminated equipment
- contaminated environment
- contaminated medications (lower risk)
What equipment can spread adenoviruses through contamination?
- tonomometer tips
- opthalmoscopes
- slit lamps
- trial contact lenses
Prevention for adenoviruses in opthalmology
- meticulous HH
- gloves during outbreaks and when exposed to patients excretions or tears
- disinfect tonometer tups
- single dose vials
- clean and disinfect surfaces before patients, between patients, and EOD
In ophthalmology, what viruses are spread in similar ways to adenoviruses?
- Coxsackievirus
- Enterovirus
Methods for disinfecting tonometer tips
5-10 minute soak in:
- 3% hp
- 70% isopropyl or ethyl alcohol
- 5000 ppm bleach
blepharitis
inflammation/ infection of the eyelid
Endopthalmitis
inflammation/ infection of the intraocular fluids (anterior and vitreous tissues)
Intravitreal
Injection of meds into vitreous chamber
intracameral
injection of meds into anterior chamber
Keratitis
inflammation and/or infection of the ocular external surfaces (conjunctiva and cornea)
inflammation of the retina
Retinitis
Noninfectious inflammation of vitreous and/or anterior chamber following intravitreal injections and/or surgery
sterile endophthalmitis
Toxic anterior segment syndrom
acute, sterile inflammation following anterior segment surgery
What disease is associated with contact lenses?
Keratitis
What microorganisms are associated with contact lenses?
P. aeruginosa
Filamentous fungi
What organisms are most often associated with infectious endothalmitis
Skin commensals
esp Staph and strep
The U.S sees most of the following compared to other countries:
- gram negative isolates
- gram positive isolates
- fungal isolates
- parasitic isolates
Gram negative isolates
Source of infectious endophthalmitis
- organisms introduced at time of surgery/ trauma
Level of disinfection for diagnostic laser lens
HLD
Level of disinfection for fundus contact lenses
HLD with 1:10 bleach for 25 minutes
Level disinfection lacrimal lavage probe
sterilization
Level of disinfection- occuluders
Low level, wipe with 70% alcohol
Level of disinfection: Opthalmoscopes
Low level, wipe with 70% alcohol
Level of disinfection phoropter
low- wipe with 70% alcohol
Level of disinfection: scleral depressor, lid elevertors, specula, forceps
Sterilize
level of disinfection- tweezers in eye doctor
Sterilize
IP for tonopen
use sterile, disposable tonopen cover for each pt exam
Organisms that penetrate intact epithelium
- N. gonorrhoeae
- N. meningitidis
- S. pneumoniae
- L. monocytogenes
- C. diphtheriae
What bacteria are associated with kertitis in cooler climates?
S. aureus
C. albicans
What bacteria are associated with eye infection in homeless populations?
S. pneumo
Moracella spp.
Most common virus to cause pink eye
Adenovirus
Most common bacteria to cause pink eye
S. penumo
S. aerues
Organisms most commonly associated with eye infections in infants
- gonnorrhea
- chlamydia
If patients require this medical device, they are more likely to get eye infections with gram negative bacteria like kelbsiella, proteus, and pseudomonas
ventilator
What risks are associated with keratitis
contact lenses
trauma
refractive surgery
What microorganisms cause keratitis after refractive surgery
S. aureus
NTM
What disease have potential to be spread through corneal transplant?
- CJD
- HBV
- Rabies
- HSV
Sources for TASS
- handling/ cleaning surgical instruments
- contaminated solutions
- contaminated intraocular lenses
- toxic meds
- powder gloves
- residue on instruments
How do most bacterial healthcare associated pneumonias occur?
Organisms colonizing the oropharynx or upper GI tract are aspirated
Bacteria associated with contaminated aerosols that cause penumonia
Legionella
Aspergillus
Serratia marcescens
Most common routes of transmission associated with respiratory care
- Droplet nuclei
- direct contact with contaminated fluids, hands, and equipment
measures how fast and how much air you breathe out
spirometer
Which is safer, enteral or parenteral nutrition?
Enteral
When should you change the ventilator circuit?
if visibly soiled or malfunctioning
Risks for respiratory infections
- age
- severe underlying disease
- immunosupression
- enteral feeding
- thoracic or abdominal surgery
- invasive ventilator support
Where are the following organisms found as common commensals?
- viridans strep
- coagulase negative staph
- Haemophilus spp.
- Neisseria spp.
- Moracella spp.
- Peptostretococcus spp. (gram positive cocci)
- Stomatococcus spp. (gram positive cocci)
- Prevotella (gram negative cocobacilli)
- Candida
Respiratory tract/ upperGI
What level of disinfection is required for mechanical ventilators
LLD of surfaces
Caring for breathing circuits, humidifiers, and het/ moisture exchangers (HME)
- don’t change unless visibly soiled or malfunctioning
- periodically discard condensate
Level of disinfection for nebulizers between patients
HLD
Level of disinfection between patients for mist tents
HLD
Level of disinfection for portable respirometers and vent. thermometers
HLD
Level of disinfection for resuscitation bags
HLD
Do you have change mist tents for the same patient
No, not recommended to change
Disinfection for small volume nebulizer in between uses for the same patient
clean, disinfect, rinse with sterile water
Level of disinfection incentive spirometry and airway clearing devices
Single use
Cleaning/ disinfection for pulmonary function testing
None for internal machinery
change mouthpiece and filter between patients
LLD of surfaces handled by patient between patients
IP for tracheostomy care
- tracheostomy - sterile conditions
- use gown, gloves, aseptic technique to replace trach tube
- no antibiotic cream
- NO routine cuff deflation
- ensure proper cuff pressure
Level of disinfection for trach tube
HLD or sterilization
IP suctioning resp secretions
- open system- use new sterile catheter each time
- Sterile saline
IP for artificial airways
- tracheostomies only for critically ill pts needing long term intubation
- elevate head 30-45 degrees
- oral over nasal intubation
- ensure proper cuff pressure
- No routine cuff deflation
PPE for suctioning a trach
Eye protection
mask
gloves
gown
Is routine PEP with antimicrobials to prevent VAP recommended?
No
Pressure for OR
Positive pressure
ACH in OR
20
humidity OR
20-60%
Temp OR
68-75
Traffic zones in surgery
Unrestricted
Semi-restricted (hosp attire and cap required)
Restricted zones (masks required, keep door closed)
Goal to limit traffic
What are the four levels and gowns and what is the most resistant to fluid?
4 levels
Level 4 is the most impermeable
Skin prep for surgery
- pre-op cleansing (night before and morning of surgery)
- Apply antiseptic and allow to dry
- if hair removal necessary, remove with clippers right before surgery
% probability that the product is sterile
microbiological safety index, the higher the number, the more sterile
How often should the policy for aseptic technique be reviewed
annually
scrub process surgeons
- remove jewelry
- clean nails
- scrub with antimicrobial soap for manufacturers recommended time (2-6 minutes)
- Use ABHR with persistent activity
What if TB patient needs emergency surgery?
- intubate/ extubate in negative pressure room
- surgery at time with minimum surgeons and personnel
- portable HEPA filter
- N95s
- Anesthesia circuit for .3 um, and change after surgery
True or false: HCP are at increased risk of latex allergy
True
Who to give SSI data and feedback to
individual surgeons confidentially
What increases the risk of a surgical site infection (pathogenesis)?
1) inoculum of bacteria
2) virulence
3) Adjuvant effects of the microenvironment
4) Impaired host defenses
What body systems have higher numbers of bacteria and therefore can increase the inoculum of bacteria?
GI
Female genitourinary
Respiratory tract
Bacteria that cause SSIs and can cause severe infections due to their virulence
S. aureus
S. pyogenes
C. perfringens
Example of bacterial synergism
Bacteroides fragilis + gram negative bacteria- much more virulent
Wound left open at end of surgery, heals by granulation and contraction
Secondary closure
Part of healing process in which pink tissue containing connective tissue and capillaries forms around edges of wound
Granulation
Wounds closed a few days after surgery
Secondary closure
When might secondary closure be preferred?
Massive contamination
Polyester foam over wound, transparent plastic adhesive drape over foam and surrounding skin, suction at port site that removes inflammatory fluids
Negative pressure wound therapy (NPWT)
Is pressure irrigation recommended for high-risk grossly contaminated wounds?
No studies, may make contamination worse
Surgical Care improvement Project Measures
1) antibiotic given 60 minutes pre surgery (or 120 for vanco or fluoroquinolones)
2) Consistent with recommendations based on most likely organisms
3) Discontinued 24 hours post-op (or 48 hours for coronary artery bypass graft)
Steps to managing a wound
- open and drain the wound (get culture here)
- Debridement
- Remove foreign body (suture material, judgement for implants)
- antimicrobial management
- wound management
When managing an open wound, what is the best method to cover?
saline-soaked, loosely packed gauze
How often to change saline-soaked gauze in open wound?
3x per day
ASA score: 21 year old, well conditioned male athlete undergoing elective groin hernia repairs
1
ASA score: 46 year old woman with mild but controlled hypertension undergoing a laparoscopic cholecytectomy
2
cholecytectomy
Surgical procedure to remove gall bladder
ASA score: a 53- year old man with insulin-dependent diabetes and coronary artery disease undergoing elective aortofemoral bypass
3
aortofemoral bypass
procedure that bypasses blocked or diseased large blood vessels in the abdomen and groin
ASA score: a 62-year old woman on chronic renal hemodialysis undergoing emergency laparotomy for perforative divertivulitis
4
ASA score: a 58-year old man with morbid obesity, type 2 diabetes, and shock undergoing extensive debridement for streptococcal necrotizing fascilitis
5
Carotid endarterectomy
Surgery to remove plaque buildup in common carotid artery
Laminectomy
Surgery in which surgeon removes part or all of the vertebral bone to help ease pressure in spinal cord
Laparotomy
Surgical incision cut into abdominal cavity
Craniotomy
Part of skill temporarily removed to expose brain and perform intracranial procedure
Ventricular shunt
Cerebral shunt that drains excess CSF when there is an obstruction
Coronary artery bypass graft
surgical procedure that restores blood flow to the heart by bypassing blockages in the coronary arteries
Colon resection
surgical procedure to remove part or all of the colon or rectum
Common organisms that infect indwelling medical devices
S. aureus
S. epidermidis
Pathways for infection of indwelling medical devices
- Introduction of organism at time of surgical implant
- contiguous spread of post-op wound infection
- hematogenous seeding
Host risk factors for indwelling medical device infections
- Previous surgery at the same site
- infection elsewhere in body
- diabetes
- corticosteroids
- poor nutritional status
- irritative skin conditions
- obesity
(generally things that lead to slower skin healing)
3 types of prosthetic joint infections
- early infection (within 3 months)
- delayed infection (3-24 months after surgery)
- late infection (2+ years after surgery)
What is late infection of a prosthetic joint typically from?
hematogenous seeding
What organisms typically causes late, fulminant infection of prosthetic joints?
S. aureus
GAS
What organisms typically cause indolent late infection of prosthetic joints?
coagulase-negative staph
Propinobacterium
How to test for and dx prosthetic joint infections
clinical symptoms
Imaging
labs (aspiration of synovial fluid (leukocytes, gram stain and culture)
histopathology (after surgery)
How to prevent implantable joint infections
- screen host and treat infections before surgery
- OR environment
- surgical prep (skin prep, hair removal with clippers, prophy antibiotics)
How to manage infections in implanted devices
Surgery and 6+ week antibiotics
- Single stage exchange
- 2 stage exchange
- arthrotomy and debridement and 6-8 weeks antibiotics (only select pts)
What typically causes early prosthetic valve endocarditis (PVE) within 12 months of valve replacement?
perioperative or immediate post op HH
What organism is responsible for most prosthetic valve endocarditis infections and mortality?
S. aureus
What symptom is most common with prosthetic valve endocarditis
Fever
What are the common echocardiogram findings in prosthetic cardiogram endocarditits?
- vegetations
- periprosthetic abscess
- new paravalvular regurgitation
What is paravalvular regurgitation?
Leak caused by space between the heart tissue and valve replacement
What organisms to expect if there are symptoms for prosthetic valve endocarditis but cultures are negative
HACEK group
What is the treatment for prosthetic valve endocarditis?
antimicrobials for 6+ weeks and likely requires surgery
Prevention for prosthetic valve endocarditis
prophy antibiotics with vanco/ gentamycin
Most common cause of defibrillator/ pacemaker (cardiovascular implantable electronic device) infections
hematogenous seeding of bacteria, esp S. aureus
Ways that cardiovascular implantable electronic device infection presents
Generator pocket infection or
Intravascular electrode infection
What should be a consideration if there is a recurrent pocket infection?
Endocarditis
Most common organism to cause generator pocket infection
S. aureus
When should the cardiovascular implantable electronic device be removed?
If there is a intravascular electrode infection
Prevention for cardiovascular implantable electronic devices
Prophy antibiotics
The following sites are infection locations for this type of device:
- surgical site
- driveline exit site * most common
- device pocket
- pump
- pump pocket
Left ventricular assist device
Symptoms of systemic left ventricular assist device infection
abscess formation on pump\
fever, pain, local swelling
Sepsis, endocarditis, cerebral embolism, multiorgan failure, death
Best method to dx endocarditis
transesophageal echocardiogram
Diseases that can be passed through tissue allograft implants
CJD
HIV
Hep B
Hep C
HSV
Cytomegalovirus
Clostridium
Fungi
Rabies
HPV
Who screens tissue for tissue allograft
American Association of Tissue Banks
Prevention of infection in implants: pre-operative
- Screen patient (medical history, clinical evaluation, pre-op testing)
- ID and treat infections before elective surgery including dental surgery for cardiac
- Pre-op antiseptic shower
- skin prep
- hair removal by clippers before surgery
how to prevent spinal implant infection
make sure implant is sterile and cover with a sterile drape
Treatment for spinal implant infection
removal and 4-6 weeks antimicrobial thearpy
Prevention of infection in implants: Peri-operative
- help maintain normothermia
- prophy antibiotics and maintain levels throughout surgery
- HH & sterile technique
- 3 sets of gloves- outer set for draping
- OR environment
- prevent hematoma formation
Prevention of infection in implants: post- surgical
- minimize hematoma
- monitor wound/ infections
- heart valves- antibiotics for dental and high risk procedures
If someone with an implant has S. aureus, what is the assumption
assume infected hardware
Out of all the implantable devices, what one has the highest risk of infection?
Ventricular assist device
ventriculoperitoneal (VP) shunt
surgical procedure that involves implanting a thin plastic tube to drain excess cerebrospinal fluid (CSF) from the brain’s ventricles to the abdomen’s peritoneal cavity
Endocarditis symptoms
FROM JANE
Fever
Roth spots
Osler nodes
Murmur
Janeway lesions
Anemia
Nail-bed hemorrhage
Emboli
Gram negative fasticious coccobacilliary organismms that grow slowly in blood culture media and can cause endocarditis
HACEK group
Haemophilus
Actinobacillus actinomycetemcomitans
Cardiobacterium hominis
Eckinella
Kingella
Process of combining, mixing, or altering ingredients to create a medication tailored to the needs of an individual patient when there is not a drug commercially available
Drug compounding
What are the most common products of sterile compounding?
- large volume IV solutions
- small volume IV solutions
What type of hood do they use for sterile compounding?
Laminar airflow + Hepa filter
Pharmacy responsibilities
- handle preparation and storage of compounded sterile and nonsterile preparations
- actively participate in aseptic training of staff to prepare compounded preparations
- management- ID staff who would benefit from education and evaluation of aseptic technique
- Coordinate medicine recalls
What is the primary engineering control for preventing contamination of compounded sterile preparations?
Compounding unit capable of ISO 5 air cleanliness + laminar airflow + biosafety cabinet
<= 100 particles per cubic ft or 3520 particles per cubic meter
International Organization for Standardization Class 5 (ISO 5)
Where do all PN fluids need to be prepared? (Iso class)
ISO class 5
What type of unit is required for hazardous drug preparation?
Biological safety cabinet or compounding aseptic containment isolator
How often do sterile compounding employees have to train and demonstrate competency?
at least annually
Every 6 months for garbing and HH
How do they test that hcp maintains sterility in compounding
Finger and thumb sampling on gloves, expect 0 cfu/mL and <=3 CFU/ mL after media testing
PPE in compounding
Sterile gloves
cap
shoe covers
mask
gown (only reusable item)
Infection prevention used in sterile compounding to maintain sterility of gloves
regularly clean gloves with 70% isopropyl alcohol
Iso class 3- Iso class 8- what happens as you increase in #
Iso class 3 starts at 35.2
Every isoclass is 10x the number of particles from the iso class before it
How many air exchanges and what type of filter is required for sterile compounding?
at least 15 ACH
HEPA filter
What is an example of a department where it’s appropriate to do regular airborne sampling?
Sterile compounding for particulate matter
These diseases can be found in immunocompromised patients if nearby ground is disturbed or there is exposure to bird droppings
Aspergillus
Cryptococcus neoformans
Histoplasma capsulatum
Coccidioides immitis
What organism is associated with “cloud shedding”
Staph aureus
What are the requirements for air intake?
Outlets need to be at least 25 ft from air intake systems
Bottom of outdoor intakes:
- 6 ft above ground
- 3 ft above roof level
Away from medical surgical vac systems
Away from areas with car fumes
Filtration methods for pre-filters (Low-medium efficiency, 20-40%)
- Straining
- Impingement
- Interception
Filtration methods for high-efficiency filters (>=90%) used in most areas of the hospitals
- Diffusion
- Electrostatic
How are high efficiency filters tested?
Dust spot
What size particle do HEPA filters remove, and how efficient are they?
> =0.3 um
99.97% efficient
Where to use HEPA filters
PE
Test for HEPA filter
Diothlphthalate (DOP) test
What organisms does ultraviolet germicidal irradiation work for?
- vegetative bacteria
- vegetative fungi
Do not work to kill fungal spores
Temperature for air in most occupied spaces
68-73
Pace of laminar air flow
90 ft/ min
How far does med prep have to be from the sink?
3 ft
There are several limitations of air sampling, give a few examples
- lack of standards linking fungal spore levels with infection*
- lack of standard protocols for testing
- substantial lab support needed
- culture issues (false negatives, lag time)
- unknown incubation period for aspergillus spp infection
- Variability in sampler redings
- sensitivity of sampler used (volume of air sampled)
- Lack of details in literature about describing sampling circumstances (unoccupied rooms versus occupied rooms)
- Lack of correlation between fungal strain from env and clinical specimen
- confounding variables with high risk patients (visitors, time outside PE)
- Need to determine idea temp for incubating cultures
In this method of air sampling, you put a petri dish with agar in the area you want to sample
Settle plate
What are settle plates best suited to measure?
Larger particles, not sensitive to respirable
This method of air sampling collects large volumes of air in a short period
Solid impactor (slit or sieve impactors)
What are solid impactors best suited to measure?
Detect low numbers of fungal spores in highly filtered areas
Survival time s. aureus
12 months
Survival time C. diff
5 months
Survival time norovirus
2 weeks
Survival time acinetobacter
11 months
Survival time pseudomonas
16 months
removal of foreign mater material from object normally accomplished using water with detergents and enzymatic products
Cleaning
Reduction in microbial population on an inanimate object to a safe or relative safe level
Sanitizing
Elimination of many or all pathogenic organisms with exception of bacterial spores
Disinfection
What should IP know about their detergents/ disinfectants?
- name
- active ingredient
- directions
- where/ how used
- manufacturer info
What are the two zones of care
Patient zone
Healthcare zone
Moments of HH for environmental services
- Before entering room/ gloving
- After leaving room/ removing gloves
- Before handling clean linens
- After bagging soiled linen and placing it on a linen cart
- After collecting and bagging trash and placing it in a trash cart
- After handling soiled equip (mops, cloths/ buckets)
- After using bathroom
- Before/ after eating
Survival time enterococcus
46 months
Survival time klebsiella
30 months
Who should write the cleaning and disinfection policies?
Multidisciplinary team
disinfecting agent to kill most viruses and all vegetative bacteria, except tubercle bacilli
Low-level disinfection
Disinfectants that kill most bacteria, fungi, viruses, and mycobacteria, but not bacterial spores
Intermediate-level disinfection
Disinfectants that eliminate all microorganisms from an instrument or surface, except for a small number of bacterial spores
High-level disinfection
Common disinfectants used in environmental services
- quat ammonia
- bleach
- hydrogen peroxide
Bleach dilution for nonpourous surfaces
1:100
Bleach dilutions for pourous surfaces
1:10
Chemical to clean room with or after C. diff patient
1:10 bleach or EPA sporicidal agent
terminal cleaning of C. diff room
- UV or HP recommended
- replace privacy curtain
When should EVS change the privacy curtain?
C. Diff
Noro
MDRO
Terminal cleaning of room with noro/ diarrheal outbreak
- UV/ HP
- Steam clean carpet upholstry
What chemical is recommended to clean nurseries?
Quat
Chemical to clean rooms for SARS
1:100 bleach
PPE for EVS in SARs room
Gown
Gloves
Mask
Protective eyewear
Indicators of bed bugs
Bites
Casings
Fecal stains
Skin casts
Sweet musty odor
How EVS to clean room with bed bugs
- Place belongings in plastic bags/ sealed containers
- Remove clutter
- Vacuum with HEPA filter
- Clean reusable equipment (ie walker)
- call exterminator
- HCP- Protective gown/ gloves
Cleaning policies and procedures are required to include:
- address dept concerns
- specify cleaning procedures
- list cleaning agents and equipment
- provide cleaning schedules
- optional: quality control
Cleaning mattresses and pillows
- discard when cracked, torn, or permanently stained
- disinfect between patients and when visibly soiled
EVS commode
clean and disinfect daily and when visibly soiled
Dump and decontaminate before taking out of room
EVS bathroom cleaning frequency
daily and when soiled
During diarrheal outbreaks- 3x per day
Types of antiseptics
Chlorohexidine*
Tricolsan
Chloroeylenol (PCMX)*
Iodophor
Quat
Alcohol*
*most popular
How often to change mop solution
Every 3 rooms or after 60 minutes, whichever comes first
Describe UV radiation for terminal cleaning
- terminal cleaning
- No need to shut off HVAC
- Move furniture away from walls
Describe HP for terminal cleaning
- 2-5 hours
- shut off HVAC and tape doors
Process for cleaning OR
1) before first case of day: wipe and disinfect horizontal surfaces
2) After each case:
- decontaminate horizontal surfaces, equip, exam tables, anethesia machines, med carts, other equip
- change cloths freq and after cleaning blood and body fluid
- clean and disinfect floor around pt area
3) conclusion of day:
- decontaminate all items and wet vac
Methods to evaluate effectiveness of cleaning
- visual
- ATP bioluminescense (not indicative of pathogen- acceptable or unacceptable)
- Fluorescent markers (tag before cleaning)
Most effective at immediately reducing bacterial counts on hands
Alcohol
Most persistent antimicrobial activity in antiseptic
CHG
Does alcohol have a residual antimicrobial effect?
No
Concern with Hexachlorophene as surgical scrub
Absorbed into blood after repeated use
Microbe detected in outbreaks in neonatal units, military field hospitals
Acinetobacter
Sources acinetobacter outbreaks/ infections
- hydrotherapy burn unit
- Hands of HCP
- Contaminated irrigation tubing, burn unit
- contaminated endoscopes for upper GI/ biliary
- other sources: sinks, resp theapy equip, disinfectants, distilled water
This organism survives in moist environmentsl and has minimal nutritional requirements. It tolerates a variety of temps, and has innat antibiotic resistance
P. aeruginosa
What organism is most likely to contaminant a disinfectant, germicide, solution, or antiseptic?
P. aeruginosa
Environmental gram negative that is associated with cystic fibrosis patients
Burkholderia
Sources of outbreaks of burkholderia
- intra-aoritic balloon pumps
- contaminated water
- resp therapy equip
- contaminated disinfectants
This environmental gram negative can cause abcesses, meningitis, conjunctivitis, wound infections, pneumonia, and has antimicrobial resistance. It has been associated with resp therapy equip, contaminated disinfectants, and ice machines
Stentophomonas maltophila
Where do enterococci colonize?
Human GI tract and biliary tract
Enterococci have both intrinsic and acquired resistance to many anti-microbials, what do they have intrinsic resistance to?
- B-lactams
- aminoglycosides
- clindamycin
- fluoroquinolones
- TMP-SMX
Disease that enterococci is often associated with
Prosthetic heart valve endocarditis
Enterococci is the ____ most common cause of SSIs
3rd
IP guidance for VRE:
- antimicrobial stewardship, esp for vancomycin and cephalosporins
- facility-wide education on infection control, including HH
- Early detection, prompt implementation of barrier precautions
- Decolonization
Organisms associated with water
- pseudomonas
- acinetobacter
- moraxella
- aeromonas
- xanthomonas
- legionella
- aspergillus
- fusarium
- atypical mycobacterium
Diseases that pass through contaminated equipment
Pseudomonas
NTM
Most commonly reported waterborne pathogesn
Pseudomonas
Legionella
This type of organism may be found when there is excessive moisture around pipes and insulation, condensation in drain pans, or flooding
Fungi
Organisms that can grow in eyewash stations
Acanthaemobae
Pseudomonas
Legionella
IP for potable water system
- sufficient pressure to operate at max demand
- isolation valves to separate/ turn off parts of water system
- install vac breaker on faucets, prevent backflow
- avoid floor drains
- no drainage piping in ceiling or exposed
- avoid dead ends
These organisms can grow in ice chests and machines
Cryptococcus
NTM
Pseudomonas
Legionella
Enterobacter
What is the HACCP?
Hazard analysis and critical control point plan
Water risk assesment
Weekly- monthly cleaning process for ice machine
discard ice, clean chest with detergent then chlorine solution, let dry and return to service
Monthly- quarterly cleaning process for ice machine
Discard ice from machine, clean with detergent, take apart and check lines, circulate 50 PPM chlorine for 4 hours, remove chlorine solution, flush with tap, return to service
How often should pools be filtered?
3x per day
How often should pools be drained and disinfected?
every 1-2 weeks
How to clean after flooding/ leakage
remove moisture source
clean in 24-48 hours
disinfect with bleach solution
thoroughly dry
IP for water management
- facility risk assessment for areas of potential growth or transmission
- designs to reduce risk of microbial growth/ release
- compliance to maintenance practices that help control transmission risk
- employ remediation measures during emergencies
- consider disinfection modalities when surveillance or risk assessment indicates a need
Problems with hyper-chlorination treatment of water system
Temporary
Byproduct trihalomethanes
Corrosion
Taste and odor
Benefit of monochloramine treatment of water system
Can penetrate biofilms
Problems with monochloramine treatment of water system
Taste and odor problems
Trihalomethanes
Benefits of chlorine dioxide treatment of water system
No by-products
Breaks down biofilm
Long-term effects
minimal corrosion
Problems with copper/ silver ionization treatment of water system
Copper may deposit, localized corrosion
Copper toxic to aquatic species
Benefits of copper/ silver treatment of water system
no by products
long term-effects for hot water
Problems of ozonation treatment of water system
Some toxic byproducts
Odor problems
potential corrosion
No long term effects
does not work on biofilms
How to test biofilms
cannot culture
PCR, sequencing of NAAT
What is the amount of increased resistance of biofilms to antibiotics
1000 x
What are the clinical consequences of biofilms?
- metastasis (release) of attached microorganism to distal sites
- Fragments of the biofilm can spread infection
- increased resistance to antibiotics
- Neutralization of host defense mechanisms
- enhanced exchange of genetic material: more virulence and resistance
- increased # organisms per unit of tissue in indwelling medical device
- increased occlusion and reduced flow of catheter lumens
Diseases associated with biofilms
- otitis media
- sinusitis
- valve endocarditis
- Cystic fibrosis
What organisms are in healthcare textiles?
- Gram negative bacteria
- Coagulase negative staph
- Bacillus spp.
- Normal skin flora
Clean state, free of pathogens in sufficient numbers to minimize infection risk (specifically for textiles)
Hygienically clean
Regulating agencies for healthcare textiles
FDA
OSHA
EPA
What is the ideal level of moisture in healthcare setting walls/ floors/ etc.
<20%
Process to assess the impact of construction and renovation on HCF on ICP programs and practices, and ensures new construction is designed to meet the needs of the anticipated pt population
Infection Control Risk Assessment (ICRA)
Written work process and equipment requirements to manage potential infection risk from proposed construction
Infection control risk mitigation recommendations (ICRMR)
Agency that writes construction and renovation in healthcare standards
Facilities guideline institute (FGI)
Who should help write the ICRA?
IP, safety, engineering, HCP from affected area
Design considerations for ICRA
- # , location, and types of iso rooms and AIIR
- special HVAC needs
- # , location, and types of HH stations
- Risk assessment (including for waterborne pathogens)
- selection of surface finishing and furnishing materials
What to include in ICRMR
- pt location relative to construction, pt relocation
- containment barriers
- construction phases, impact on plumbing and HVAC
- effect of traffic flow, access to exits, life safety
- training for staff, construction workers, pts, visitors
- lav/ cafe areas for construction workers
- rqmt that new materials clean and free of damage
- how ICRMR monitored, written procedures to stop work if needed
Pressure of construction zone
Negative
What is the IP’s role in construction and renovation?
- assess needs and risks of patient staff, visitors, and population affected by construction
- Address infection prevention needs of pt and HCP that will occupy the space after construction
- provide evidence- based guidance on IP to the project design team
Considerations for plumbing design
- CMS requires water mgmt plan
- remove deadlegs or at least use valve to isolate
- consider points to inject the chlorine/ disinfectant
What can be used to contain a small job (working on ceiling)
Portable containment unit with negative air pressure machine
All workers and tools must fit in unit
Isolating ventilation in the construction space
- wrap return ducts that serve other areas in plastic
- prevent leaks
- fan and filtered exhaust grill to exterior of building
- HEPA filter required if air cannot be exhausted outside
- shutting of HVAC can negatively impact air pressure in other parts of the building
When is an anteroom required?
- for combined AII/ PE room
Who should be present at construction rounds?
Project manager
Safety
Security
Contractor Reps
What surveillance is recommended during construction projects?
active surveillance:
- airborne infection in immunocompromised patients
- review labs and postmortem data
Best practices for construction and renovation
- avoid routing construction personnel through the hospital
- strictly maintain negative pressure at all times
- prevent circulation of dust with tight barriers or enclosures
- use dust containment carts
- protect HVAC so as not to hinder negative pressure
- Recommend anteroom where workers can change into protective apparel and store and clean equipment
- Use clean and properly sized walk-off tacky mats
Positive pressure rooms
ORs, protective environment, special procedure rooms
Negative pressure rooms
- Airborne isolation rooms
- toilet rooms
- bronchoscopy
- triage, waiting room at the ER
- radiology waiting room
ASHRAE scale for filters
Minimum efficiency reporting values (MERV)
Scale: 1-16, where 16 is the highest filtration rate
Surgery airflow
noninduction, unidirectional difffusion
25-35 fpm
Where should exhaust outlets from contaminated areas be located?
Above roof
OR and cath lab pressure and ACH
positive pressure, minimum of 15 + 3 outdoor
Should you change pressure in OR for TB patient?
No, get back to AII ASAP
Minimum number of ACH for PE
12
Minimum % filter for PE
95%, filter .3 microns
Minimum ACH in AIIR
12
Add HEPA if there are less
Ancillary support areas ACH, pressure, and filtration:
Food service
Dx imagining
Treatment rooms
Sterilizing/ clean supply distribution
Other service areas
+ pressure
10 ACH
90% filtration
What is the temp for AII or PE
70-75 F
Planning checklist for environmental surveillance
- determine plan and purpose of surveillance
- Review literature for published information to guide baseline values or threshold
- establish facility-specific baseline or threshold (range of acceptable values)
- Determine actions if values exceeded
- Ensure micro lab involved in plan
- Determine sampling methods and culturing techniques
- ensure collecting/ sampling personnel trained for consistency
- Conduct sampling and quantify results
- determine if values exceed established threshold
- Analyze and communicate results, follow action plan if needed
Describe the ACH, pressure, temp, and humidity for: soiled/ decontamination
10 ACH
negative pressure
60-65 F
30-60% RH
Describe the ACH, pressure, temp, and humidity for: Assembly/ prep and pack
10 ACH
Positive
68-73 F
30-60% RH
Describe the ACH, pressure, temp, and humidity for: Sterilizer loading/ unloading
10 ACH
Positive
68-73 F
30-60%
Describe the ACH, pressure, temp, and humidity for: Sterile Storage
4 (downward draft)
Positive
up to 75F
<70
What is needed for waste to cause infection
- Dose
- Host susceptibility
- presence of a pathogen
- Virulence of a pathogen
- portal of entry
How to process microbiological waste
Chemical, thermal (autoclave), or radiological (irradiation) treatment prior to disposal as nonhazardous waste, or ship off-site as regulated waste
How to process animal waste
Evaluate for potential zoonotic exposure risk and treat on site prior to disposal
How to process waste with blood saturated materials or bulk liquids
Collect as regulated waste, use chemical bleach or thermal treatment on site to decontaminate and solidify bulk blood if transported off-site
How to process sharps waste
Place in appropriate rigid puncture- resistant, closeable and leakproof container for immediate disposal
How to process pathology waste
formalin fixation to reduce infectious material, then incinerate or grinding acceptable, cannot release recognizable body parts into waste stream
Who regulates waste management?
OSHA, DOT, and EPA
Objectives of waste management plan
- infectious waste safe for disposal
- minimal risk to HCP, visitors, community
- mtg or exceeding local, state, and fed regs
- educate HCP about HCP-risks and handling medical waste
Parts of the waste management chain
Designation
segregation
packaging
storage
transport
treatment
disposal
contingency planning
staff training
What disease has been passed between patients in a surgical plume?
HPV
Types of regulated infectious waste
- contaminated sharps
- microbiological waste
- animal waste
- pathology waste
- blood/ blood products
- Cat A isolation waste
Best method to transport infectious waste to be transported
leakproof carts that are cleanable
What are the documents that have to travel with waste to it’s final destination
Waste manifest
How to treat contaminated waste?
- Steam sterilization
- chemical disinfection
- gas/ vapor sterilization
- irradiation
- incineration
How to determine if sterilization of infectious waste worked
use a biological indicator
Parts of OSHA and DOT required training for WM
- Definition of infectious waste
- handling procedures
- appropriate PPE
- HH
- Labeling IW
- Post exposure management
How often does OSHA require waste management training?
First 90 days and every 3 years
Preferred waste management method for Category A waste
Use on-site inactivation (autoclave or incineration)
FDA class- device not life supporting of life-sustaining or for a use which is of substantial importance in preventing impairment of human health (example bandages, enema kits)
Class 1
FDA class: General controls alone are insufficient to provide reasonable assurance of the device’s safety and effectiveness, and there is sufficient info to establish special controls (ex- surgical gloves, contact lenses, powered wheelchairs)
Class 2
FDA class: life supporting or life-sustaining device or devices for a use which is of substantial importance in preventing impairment of human health, or the device presents a potential unreasonable risk of illness or injury (ex implantable pacemaker, automated external deibrillators)
Class 3
Animals that are not specific to the patient
Animal assisted activities
Animals are specific to patient’s therapy
Animal assisted therapy
Rule about raw food for animals in AAA or AAT
Animal cannot have eaten raw animal foods in past 90 days
How far in advance does a visiting animal have to bathe?
24 hours
Are animals allowed on the bed?
If an animal goes on the bed, there should be a barrier between the patient and the animal, preferred animal is in a carrier or on a short leash
What patients should be excluded from AAA/ AAT?
open wounds
burns
trachea
immunosuppressed
isolation
zoonotic diseases (Salmonella, TB, campy, shigella, Strep A, MRSA, ringworm, giardia, amebiasis)
What are the rules if a personal pet is allowed to visit?
- bath within 24 hours
- record of current vax before visit
- short leash/ carrier
- Staff escort in/ out of facility
- Only allowed to interact with owner and no other staff or patients
- visits limited based on predetermined factors
- inform handler they may be asked to remove pets at any time
Are comfort/ emotional support animals service animals?
No
Where are service animals allowed?
Everywhere but ORs, burn units, and sterile environment
Can service animals be where food is prepared and sold?
Yes
Can be used to measure pressure
manometer
What is the risk of rinsing medical care equipment with tap water?
Gram negative bacteria
What are some organisms that can grow in contaminated solutions (ie solution of bleach) and disinfectants?
- Pseudomonas*
- Burkholderia
- Serratia marcesens
- Stenotrophmas maltophila
Bacteria that are associated with resp equipment
Burkholderia cepacia
Stentrophomonas maltophila
Acinetobacter
Enterobacter
What is/ are the source(s) of Mycobacterium abcessus
medical instruments that were not sterilized properly
What is/ are the source(s) of Mycobacterium avium complex
potable water
What is/ are the source(s) of Mycobacterium chelonae
- Improperly sterilized medical instruments
- contaminated solutions
- hydrotherapy tanks
- Jet injectors
- Bronchoscopy
What is/ are the source(s) of Mycobacterium fortuitum
- Aerosols from showers/ other water sources
- ice
- medical instruments not sterilized properly
- hydrotherapy tanks
- deionized water
- intrinsically contaminated lab solutions
What is/ are the source(s) of Mycobacterium marinum
Hydrotherapy tanks
fish tanks
What is/ are the source(s) of Mycobacterium ulcerans
potable water
What is/ are the source(s) of Mycobacterium kansasii
potable water
Which NTM are more resistant to chlorine (rapid or slow-growing?)
slow-growing
If water is down, where should you use sterile/ bottled water?
- surgical scrub
- ER surgical procedures
- pharma preparations
- pt care equip
What is the temp for heat flushing water?
160-170F
What type of ice should you use for medicine/ solution transport
Sterile ice
What type of ice should you use for immunocompromised patients
Sterile ice
Who should be restricted from using hydrotherapy tanks and wounds
Pts with draining lessions
Examples of intermediate level disinfectants
- chlorine containing compounds
- alcohols
- some phenolics
- some iodphors
Examples of low level disinfection chemicals
- quat ammonia
- some phenolics
- some iodophors
What practices may lead a cleaning solution to be contaminated with pseudomonas or seratia (esp in phenolics or quat)
- re-dip dirty cloth into solution
- solution not changed frequently enough
- solution prepared in dirty container
- solution stored too long
- solution not prepared correctly
Infection control for cleaning solutions
Prepare daily and discard remaining solution at end of day and dry out container
Use ready-to-use wipes or solution
These chemicals help to clean off proteins, fats, etc
Detergents
If using detergents to clean, what is an important step
RINSE!
Probe that helps to look at the esophagus and determine if it is working properly
Esophageal manometry probe
Examples of equipment that require HLD
- resp therapy equipment
- anesthesia equipment
- GI endoscopes
- Bronchoscopes
- Laryngoscopes
- Esophageal manometry probes
- anorectal manometry catheters
- Endocavitary probes (vaginal and rectal)
- Prostate biopsy probes
- infrared coagulation devices
- Diaphragm fitting rings
HLD chemicals
- Gluteraldehyde (2%)
- hydrogen peroxide (7.5%)
- accelerated HP (2%)
- Improved HP
- Paracetic acid with HP
- Paracetic acid (0.2%)
- ortho-phtaladehyde (0.55%)
- chlorine based products
how often do disinfection and sterilization team members get training and competency checks?
Hire and yearly
What is AAMI’s benchmark for residual protein on instruments?
<6.4 ug/ cm
Common places for biofilms to form
- Whirlpools
- dental water lines
- hemodialysis systems
- urinary catheters
- CVCs
- endoscopes
Exposure time and temperature for most HLD
8 minutes - 45 minutes at 20C (68F)
How long after an uneventful surgery does TASS usually occur?
12-48 hours
How to spot clean surfaces with CJD
1:10 solution
Which is faster- UV light or HP for terminal cleaning?
UV light
Which terminal cleaning supplement is more effective for spores: HP or UV light?
HP
What is the temperature and time for a washer disinfector
93C (199F), 10 minutes
Washer sterilizer temp
285F (washer followed by short steam cycle)
Washer pasteurizer temp and time
70C (158F), 30 min
Time required for most liquid chemical sterilants
3-12 hours
Time and temp for paracetic acid as a liquid chemical sterilant
12 minutes @ 50-56C (122-132F)
Limitations to liquid chemical sterilants
Cannot be wrapped
Generally what are the most resistant organisms to disinfection?
Prions
Spores
oocysts and eggs
Mycobacteria
What are the most susceptible organisms to disinfection?
Most viruses
Vegetative fungi
Vegetative bacteria
What are examples of high temperature sterilization with processing times?
Steam: 40 minutes
Dry heat 1-6 hours
What are the types of low temperature sterilization and their processing times?
- Ethylene oxide gas (15 hours)
- Hydrogen peroxide gas plasma (28-52 minutes)
- Ozone (4 hours)
- Hydrogen peroxide vapor (55 minutes)
Least preferred sterilization method because items cannot be wrapped and difficult to maintain sterility
Liquid immersion sterilization
What is the heat-automated HLD method, and it’s processing time?
Pasteurization (65-77C, 30 min)
Describe intermediate level disinfectants. What can they be used on?
EPA-registered hospital disinfectant with claim against tuberculocidal activity
Noncritical patient care items
Low-level disinfection descriptions
EPA registered hospital disinfectant with no TB claim
Peracetic acid/ hydrogen peroxide advantages
- no activation required
- odor or irritation not significant
Peracetic acid/ hydrogen peroxide disadvantages
- material compatibility concerns- cosmetic and functional (lead, brass, zinc)
- Limited clinical experience
- potential for eye/ skin damage
Glutaraldehyde advantages
- Numerous use studies published
- relatively inexpensive
- excellent material compatability
Glutaraldehyde disadvantages
- Respiratory irritation
- pungent and irritating odor
- Relatively slow mycobactericidal activity (unless phenolics or alcohol added)
- Coagulates blood and fixes tissue to surfaces
- Allergic contact dermatitis
Hydrogen peroxide advantages
- no activation required
- may enhance removal of organic matter and organisms
- no disposal issues
- no odor or irritation issues
- does not coagulate blood or fix tissues to surface
- inactivates cryptosporidium
- use studies published
Hydrogen peroxide disadvantages
- material compatibility concerns- cosmetic and functional (brass, zinc, copper, and nickel/ silver)
- serious eye damage with contact
Ortho-phthaladehyde (OPA) advantages
- fast acting high-level disinfectant
- no activation required
- odor not significant
- excellent materials compatibility claim
- does not coagulate blood or fix tissues to surfaces claim
Ortho-phthaladehyde (OPA) disadvantages
- stains protein gray
- limited clinical experience
- more expensive than glutaraldehyde
- eye irritation with contact
- slow sporicidal activity
- anaphylactic reactions to OPA in bladder cancer patients with repeated exposure through cystoscopy
Advantages of peracetic acid
- rapid sterilization cycle time (30-45 min)
- low temp (50-55C) liquid immersion sterilization
- environmentally friendly by-products (acetic acid, O2, H2O)
- Fully automated
- single use system eliminates need for concentration testing
- standardized cycle
- May enhance removal of organic material and endotoxin
- no adverse health effects to operators under normal conditions
- compatible with many materials and instruments
- does not coagulate blood of fix tissues to surfaces
- sterilant flows through scope, facilitating salt, protein, and microbe removal
- rapidly sporicidal
- provides procedure standardization (constant dilution, perfusion of channel, temps, exposure)
Disadvantages of peracetic acid
- potential material incompatibility (aluminum anodized coating becomes dull)
- used for immersible instruments only
- Biological indicator may not be suitable for routine monitoring
- one scope or a small number of instruments can be processed in a cycle
- More expensive than HLD
- serious eye and skin damage
- point of use system, no sterile storage
- 2% peracetic acid only cleared by FDA as HLD in AER
Advantages: Improved hydrogen peroxide
- no activation required
- no odor
- non-staining
- no special venting requirements
- manual or automated applications
- 12 month shelf life, 14-day re-use
- 8 min at 20C HLD claim
Disadvantages of improved HP
- material compatibility concerns due to limited clinical experience
- organic material resistance concerns due to limited data
Advantages Steam sterilization
- nontoxic
- cycle easy to control and monnitor
- rapidly microbioicdal
- least affected by organic/ inorganic soils among sterilization processes listed
- rapid cycle time
- penetrates medical packing and device lumens
Disadvantages of steam
- deleterious for heat sensitive instruments
- microsurgical instruments damaged by repeated exposure
- may leave instruments wet, causing them to rust
- potential for burns
Advantages of HP gas plasma
- safe for the environment
- leave no toxic residuals
- cycle time is 28 minutes and no aeration necessary
- used for heat and moisture sensitive items sine process temp <50C
- simple to operate, install, and monitor
- compatible with most medical devices
- only requires electrical outlet
Disadvantages for HP Gas plasma
- Cellulose (paper), linens, and liquids cannot be processed
- endoscope or medical device restrictions based on lumen internal diameter and length
- requires synthetic packaging (polypropylene wraps, polyolefin pouches) and soecial container tray
- may be toxic at levels greater than 1 ppm
Advantages of ethylene oxide
- penetrates packaging materials, device lumens
- single-dose cartridge and negative-pressure chamber minimizes the potential for gas leak and ETO exposure
- simple to operate and monitor
- compatible with most medical materials
Disadvantages of ETO
- requires aeration time to remove ETO residue
- toxic!, carcinogen, and flammable
- emission regulated by states
- cartridges should be stored in flammable liquid storage cabinets
- lengthy cycle/ aeration time
Advantages of vaporized hydrogen peroxide
- safe for the environment and hcp
- no toxic residue, no aeration
- fast cycle time, 55 min
- used for heat and moisture sensitive items (metal and nonmetal)
Disadvantages of HP vapor
- medical device restrictions based on lumen internal diameter and length
- not used for liquid, linens, powders, or cellulose
- requires synthetic packaging
- limited materials compatibility data
- limited clinical use
Who should be involved with decisions to reprocess SUDs?
-Admin
-Risk assess
- Legal
- Supply chain admin
- Infection control
How often to test HLD?
Daily, discard if chemical indicator shows chemical is < minimum
Discard at end of re-use life per manufacturers instructions
What are the advantages of AERs?
- reduce errors prone to manual cleaning
- enhance efficiency and reliability of HLD
- automated and standardized reprocessing strips
- reduce personnel exposure to chemicals
- filtered tap H2O
What are the disadvantages of automated endoscope reprocessors
- failure linked to OBs
- does not eliminate pre-clean
- incompatible with certain side-viewing duodenoscopes
- biofilm buildup
- inadequate channel connectors
- scope placement MUST ensure exposure of internal surfaces to HLD/ sterilant
Should you do environmental sampling in sterile processing?
No, only if there is epi risk
Filter for sterile storage room
HEPA
What is the shelf life for re-processed endoscopes?
7 days
What infections have been transmitted by improperly disinfected GI endoscopes?
Salmonella
Pseudomonas
Over 150 infections transmitted
What infections have been transmitted by improperly disinfected bronchoscopy equipment?
Mycobacterium tuberculosis
NTM
Pseudomonas aieruginosa
Steps to reprocessing endoscope
- clean (water and enzymatic cleaner)
- disinfect (immerse)
- rinse
- dry (forced air + alcohol)
- store
Removes fine soil from instruments after manual cleaning, before HLD and sterilization
Ultrasonic cleaner
What type of water should be used in an automated washer/ disinfector
RO or DI
How often does AAMI recommend monitoring washier disinfectors with a challenge test? and what does the challenge test entail?
Once a week
Challenge test mimics protein, dried blood, polysaccharides
When do you complete the instrument inspection?
Clean side, after cleaning, before HLD or sterilization
Chemical indicator: external time/ temp/ and pressure (says item went through the autoclave, on tape or peel pack)
Class 1
Chemical indicator: Bowie Dick test- looks at efficiency of air removal
Class 2
Chemical indicator: Internal time and temp (rarely used)
classs 3
Chemical indicator: internal, reacts to two or more parameters (rarely used outside of ETO)
class 4
Chemical indicator: integrators- melted chemical pellet reacts to all parameters in steam cycle
Class 5
Emulating indicators- cycle specific
Class 6
What type of sterilizer is the Bowie Dick test used in?
Pre-vac (not gravity)
How often should the Bowie Dick test be run?
Daily
What does the class 5 chemical indicator measure (integrators)
time, temp, steam
Add to each layer in the most challenging place
When you run a biological indicator, you should also run a ______
Control
When to use BI
- during installation of sterilizer
- once daily (before first load for steam and HP
- Every gravity steam load
- every ETO load
- all implant loads
Where to place BI in steam sterilizer
Loaded chamber over drain (coolest part of sterilizer)
Where to place BI in gas sterilizer
Middle of loaded chamber
Where to place BI in HP sterilizer
Lowest shelf towards back of chamber
Causes of sterilization failure
- improper cleaning
- improper packaging
- wrong pack material
- excessive packaging
- improper loading/ overloading
- No separation between packages or cassettes
- improper timing and temp
- incorrect operation of sterilizer
What is used to vaporize HP in HP gas plasma sterilization?
Radio frequency
Probability of microbe surviving sterilization is 1 in ______
1,000,000
Probability of single viable microbe living on product after sterilization
Sterility assurance level
What is the SAL before and after sterilization?
Sterility reduces microbe from 10^3 to 10^6
Types of high temp steam sterilizers
- Gravity Displacement (250 F)
- Dynamic air removal (270-275F)
Types of Dynamic air removal steam sterilizers
- pre-vac steam sterilizer (sucks out the air)
- Steam flush pressure pulse sterilizer (above atmospheric pressure)
Parameters of steam sterilizer
- steam
- pressure
- temperature
- time
Steam process
- conditioning
- exposure
- exhaust
- drying
Gravity displacement sterilizer exposure time and temp
250 for 30 minutes
Dynamic air removal pre-vac steam sterilizer exposure time and temp
270 for 4 minutes
Time and temp for IUSS
132C (270) for 3- 10 minutes
Exposure time and aeration time for ETO
2.5- 6 hour exposure
8-12 hour aeration
How ETO works to sterilize
Alkylation
BI spore to test ETO
Bacillus atrophes
BI to test most sterilizers
Geobacillus stearothermophilus
What materials are not compatible with HP gas plasma
-liquids/ powders
- materials that absorb liquids
- items with cellulose (cotton, paper, linens, towels, gauze, sponges)
Run time for HP gas plasma sterilization
28-75 minutes
Run time for ozone sterilization
4 hours 15 minutes
rendering item safe to handle
Decontamination
Declaration by med device manufacturers that a product is sterile on the basis of physical or chemical process data after validating the cycle using BIs
Parametric release
Part of CI labeling that provides a value or values of a critical variable at which the indicator is designed to reach it’s end point as delivered by the manufacturer
Stated value
Where should the decontamination air be exhausted?
outside
PPE for decontamination
- Gloves (heavy duty)
- Fluid resistant mask
- Eyewear
- Gown
- shoe covers
- surgical attire (hc laundered scrubs)
No long nails or polish, no jewelry
Instrument sets going into the sterilizer should not weigh more than ____ lbs
25 lbs
What are the types of packaging materials?
- textile wraps (woven- reusable/ nonwoven- disposable)
- Peel pouches
- rigid containers (metal or plastic)
When are peel pouches preferred?
When visibility is important
Which side of peel pouch can you write on?
plastic side only
What are the parameters of sterilizers that must be tracked?
- Temperature
- time
- pressure
- vacuum levels
- moisture conditions/ relative humidity
- chemical concentrations
- adequate air removal
If physical monitors of sterilizer are not correct, what next?
- Do not release for use
- notify supervisor to initiate follow-up
- recall items in load
When to read external CIs
When unloading sterilizer, dispensing/ issuing for use, and before item opened in ER
Per AAMI ST79, is a recall required if the cause of failure is immediately ID’d as the result of operator error and confined to one load
No
Documentation for sterilization
- sterilizer lot information
cycle documentation;
- lot #
- date
- time
- contents of load
- dept
Description of items
- exposure time and temp
- operator name
- results BI and Bowie Dick, CI in PCD, any reports of inconclusive or nonresponse challlenges
Where should heavy items be stored in sterilized item storage?
middle shelf
Item sterile unless integrity of packaging compromised
Event related sterility
What compromises event related sterility
- env source contamination (moisture, vermin, air movement with traffic)
- storage and distribution practices (open versus closed shelving, transport)
- inventory control
- frequency of handling between distribution and user
Who regulates sterile processing?
OSHA
EPA
FDA
Who makes recommendations for sterile processing?
HICPAC
AAMI
AORN
FGI
What document regarding disinfection and sterilization do TJC and CMS use for accredidation?
ANSI/ AAMI ST 79- Comprehensive Guide to Steam Sterility in HCF
Sink requirements for decontamination
3 bay sink
Clean
Initial rinse
Final Rinse
How far do sinks need to be from the floor in decontamination? How deep?
36 inches from floor
8-10 inches deep
How often to change enzymatic cleaner
After each use (no antimicrobial)
How often to run cleaning verification tests? (ie bioluminescence markers/ cavitation testing in ultrasonic cleaner)
Daily
How often to empty, clean, and disinfect ultrasonic washer
@ least daily, better if after each use
How to disinfect ultrasonic cleaner
wipe with 70-90% alcohol
Dry with lint-free cloth
How often to test washer/ disinfectors and washer/ decontaminators
daily
What level of disinfection does a cart washer/ disinfector offer?
low-intermediate level disinfection
How often to test/ clean cart washer/ disinfector?
daily
How often to test AER and how often to use CI or test strip?
Weekly testing
Use test strip or CI before each use
Process for manual cleaning verification
- visible inspection (with magnifying glass or camera)
- test with soil/ protein/ ATP and or hemoglobin tests
What is considered clean?
<6.4 ug/cm^2
How often to test manual cleaning process
Daily
when new types of equip used
Test endoscopes and difficult to clean items
How often to test mechanical cleaners
daily, on all cycles
installation
after major repair
new type of solution
What is the test for ultrasonic cleaners?
Cavitation test (aluminum foil videos online)
Documentation required for HLD solution
Shelf life
Date opened
Use-of life open container
Date activated/ diluted/ poured
Re-use life of solution
Tips for loading the sterilizer
- absorbent materials at the top
- stand peel pounces on side and in same direction
- containers should be same manufacturer
- tilt anything that may hold water on edge
Tips for unloading the sterilizer
- ensure cycle parameters met
- allow to cool before unloading
- check package and CI/ BI
- any wet/ damaged or failed BI need to be returned to decontamination
What tests need to be run after a sterilizer is installed, relocated, malfunctioning, repaired, or had a process failure?
3 BI PCD (preferably from different manufacturers)
follow with 3 Bowie dick
run on shortest cycles
What regulatory agency approves chemical indicators?
FDA
What to do if CI fails
Return load to SP
SP investigates
Do not use machine again until BI PCD known
What chemical indicators are typically used for steam sterilizers?
Type 5 or 6 CI
What chemical indicators are typically used for EO sterilizers?
Type 4 or 5
How often should routine monitoring happen for sterilizers?
At least once a week, but daily preferred
How often to use BI in EO sterilizer
each use
How often to use BI with HP sterilizer
at least daily
Steps to recalling sterilized loads:
Review log of items in load
Retrieve unused items
ID cause of failure
Quality testing
Recall report
Surveillance of involved patients
How often to clean and decontaminate reusable brushes for deontamination
Daily but preferably before each use
Objectives of product evaluation
- good performance
- good patient outcomes
- safe
- cost effective
what characteristics make a product evaluation program successful?
- executive oversight and support
- culture embraces product evaluation
- data-driven decision making process
Benefits of product standardization
- reduces inventory
- HCP more comfortable with product
What should be part of the cost considerations during product evaluation?
- cost of product
- costs beyond product (re-training staff)
% breakdown of time product evaluation committee should spend on cost and utilization
20% cost/ 80% utilization
Who should be on the product evaluation steering committee?
Sr. admin
nursing exec
med exec
supply chain exec
finance exec
quality improvement exec
PEC leaders
Who has this role on the product evaluation committee?
- actively participates in discussions and content of PEC meeting
- leads team
- develops and follows agenda
- schedules meetings
- communicates with team members between meetings
Team leader or chairperson
Who has this role on the product evaluation committee?
- provides support and guidance on navigating political and administrative challenges
- acts as liaison between PEC and other standing committees
- keeps executive management team informed on PEC activities
- Champions PEC program
Administrative representative
Who has this role on the product evaluation committee?
- provides supporting information on clinical need and product relevance
- champions PEC program to medical staff
physician reps
Who has this role on the product evaluation committee?
- Coordinates PEC logistics and activities
- provides direction on team and project management
- maintains PEC focus
- Manages team dynamics
Facilitator
Who has this role on the product evaluation committee?
- Documents discussions, ideas, actions, and decisions
- publishes PEC minutes
- maintains PEC history
- maintains and publishes log of financial impact of PEC decisions
Recorder/ Secretary
Who has this role on the product evaluation committee?
- may serve dual capacity as project team leaders, assembling task forces to work on specific PEC initiatives
- represents the facility, not their department
- provides clinical expertise and knowledge of literature, best practices, and patient care
Team members
IP role in product evaluation
assess product safety and consider cost and potential infection risks of products
The product evaluation process (8 steps)
- ID need for product (review and if needed, assign PM)
- Develop functional product specs
3 review literature, product info, other product uses - review safety/ IP implications
- Develop product trial protocol
- Conduct product trial
- Evaluate trail results
- present to PEC- final decision
What needs to happen after a product is selected?
Train employees on use
complete post-implementation surveillance
OSHA BBP mandates for selecting needles/ sharps
- safety engineered sharps/ needleless systems
- solicit input from front-line workers
- document solicitation in exposure control plan
- maintain sharps injury log
What is the process to reprocess single use devices?
Decontaminate
Functional testing
Repackage
Relabel
Sterilize
What forms are required for reprocessing Class 1 and 2 SUD?
FDA Pre-market notification 510K
What forms are required for reprocessing class 3 SUD?
premarket approval application
Can facilities reprocess SUD on site?
No, should use third party and recommend site visit
What cannot be reprocessed?
Hemodialysis filter
implants
non-hosp setting equip
General components of licensing and agreements with FDA for reprocessing SUD
- register with FDA
- report adverse events
- track reprocessed SUD medical devices
- report corrections (repairs) and removals (removed from use)
- good manufacturing process requirements
- labeling
- pre-market notification approval
Strategy to assist facilities in using their own NHSN data to generate reports that help target infection prevention efforts to areas of greatest need
Targeted assessment for prevention (TAP)
CMS requirement for IPs at hospitals
- Hospitals must have active, hospital wide program for surveillance, prevention, and control of HAIs and other infectious diseases
- Antimicrobial stewardship program
The US HHS wrote the National Action Plan to Prevent HAI: Roadmap to Elimination. What are it’s targets?
- CLABSI
- CAUTI
- SSIs
- Incidence of invasive HAI MRSA
- MRSA BSI
- C. Diff infections
- C. diff hospitalizations
What are the principle goals for infection prevention and control programs?
- protect the patient
- protect HCP, visitors, and others in the healthcare env
- cost-effectively accomplish the previous goals whenever possible
What are the principle functions of IPC programs?
- To obtain and manage critical data and information, including surveillance for infections
- To develop and recommend policies and procedures
- to intervene directly to prevent infections and interrupt the transmission of infectious diseases
- to educate and train HCP, patients, and nonmedical caregivers
Multidisciplinary IP committee (not required by TJC)
- nursing
- admin
- EVS
- Laboratory
- engineering
- pharmacy
- building management
- physicians
- surgeons
IPC responsibilities
- education
- consultation
- surveillance
- implementation science
- patient safety
- quality improvement
These are the roles of this committee:
-advocate for prevention and control of infections in the facility
- formulate and monitor patient care policies
- educate staff
- provide political support that empowers the team
Infection prevention committee
Once certified, what is the next development step?
Proficient practioner bridge
What is the APIC opportunity for advanced professionals?
Fellow of APIC (FAPIC)
Cost effectiveness: Economic evaluations- types of economic analysis studies
- cost effectiveness
- cost utility
- cost-benefit
This economic analysis compares products or interventions with different costs and potential outcomes of care. Examples are # cases of disease prevented, # lives saved, and # life years saved
Cost-effectiveness
This economic analysis adjusts the benefits of a specific intervention in terms of health prevention sores (ie quality of life years (QALY) gained(
Cost-utility
This economic analysis looks at outcomes in terms of cost
cost-benefit
Aside from cost-savings, what other benefits from IP programs can be measured?
- regulatory compliance
- decreasing malpractice claims
- protecting employees from injury
- assisting in pt safety efforts
- enhancing org. image
7 step method to create a business case
- frame the problem and develop a hypothesis about potential solutions
- Meet with key administrators
- Determine the annual cost
- Determine what costs can be avoided through reduced infection rates
- Determine costs associated with the infection of interest at your hospital
- Calculate the financial impact
- Include the additional financial health benefits
What is the goal of the IP annual risk assessment?
To set priorities and obtain support from key stakeholders
What are the steps for setting priorities in the IP annual risk assessment?
- establish a reliable, focused surveillance program based on the annual risk assessment
- Streamline data management activities
- aim for zero HAI rates
- Educate staff regarding prevention strategies
- ID opportunities for performance improvement
- Take leadership role in performance improvement teams
- Develop and implement action plans that outline the steps needed to accomplish each objective
- Evaluate the success of action plans in accomplishing the goals and objectives of the IPC plan
What should be identified in the IP annual risk assessment?
High-volume, high-risk, and problem-prone activities
What should the IP annual risk assessment be based upon?
Strategic goals and institutional findings from previous year’s activities
How to measure quality of ICP program
- customer satisfaction
- appropriateness
- efficacy
- timeliness
- availability
- effectiveness
- efficiency
Who mandates an IP annual evaluation?
TJC
What is included in the annual evaluation?
- achievements and activities of the program and support requirements
- emphasize value of IPC program to organization
- Patient outcomes and cost savings
Who should get copies of the IP annual evaluation
Widely disseminate to leaders throughout the organization (execs)
Professional & Practice Standard domains of infection preventionist
- leadership
- professional stewardship
- research
- IPC operations
- quality improvement
- IPC informatics
IP domain that includes communication, critical thinking, collaboration, behavioral science, program management, and mentorship
Leadership
IP domain that includes accountability, ethics, financial acumen, population health, continuum of care, and advocacy
Professional stewardship
IP domain that involves IP as a subject matter expert, performance improvement, patient safety, data utilization, risk assessment and risk reduction
Quality improvement
IP domain that includes epidemiology and surveillance, education, IPC rounding, cleaning, disinfection, and sterilization, outbreak detection and management, emerging technologies, antimicrobial stewardship, and diagnostic stewardship
IPC operations
IP Domain that includes surveillance technology, electronic medical records and electronic data warehouse, data management, analysis, and visualization, application of diagnostic testing data and techniques
IPC informatics
IP domain that includes evaluation of research, comparative effectiveness research, implementation and dissemination science, and conduct or participate in research or evidence based practice
Research
Career stage: IP demonstrates effective emotional intelligence, listening, and learning skills and is acquiring baseline knowledge about each dept and team in which they interact. The IP is beginning to understand the diverse areas of responsibility in her new role and is developing relationships with department staff outside of IP.
Novice
Career stage: The IP collaborates well with peer groups and can work well with diverse groups
- the IP is developing collaboration skills by assuming a role in a focused group project
- with ongoing guidance, the IP is becoming more independent in collaborating with key stakeholders
Becoming proficient
Career stage:
- The IP actively suggests and seeks ideas to improve quality, efficiency, and effectiveness
- The IP is able to prepare for group meetings by identifying key issues and expectations and is able to identify resources most likely to guide project tasks
- The IP is able to engage all members in the discussion with respect and professionalism
Proficient
Career stage:
- The IP actively pursues collaboration and discussion by facilitating and leading diverse groups, welcoming opinions, respectfully challenging perspectives, and modeling effective listening skills
- The IP encourages ownership of the process by group members, highlights group successes, builds a sense of shared accomplishment, and reinforces successes by becoming an advocate for the group’s decisions
Expert
What are APIC’s professional development tools?
- Roadmap for the novice IP
- Self-assessment tool
- Proficient practioner bridge
Benefits of IP certification per studies
- more comprehensive antimicrobial stewardship programs
- reduction in MDROs
- increase in evidence based practices
- implement best practices for immunizations, vaccine handling, and program management
- increased perceived value- competency, professionalism, growth in one’s career
Agency that makes advisory reports for hospital execs, follows regulatory issues with HAIs, and maintains hospitals in pursuit of excellence
American Hospital Association
Agency focused on using science based research to improve IP
Association for Professionals in Infection Control and Prevention (APIC)
Agency focused on surveillance and runs NHSN, they also developed Healthcare control practices advisory committee (HICPAC) which provide guidance about IPC, surveillance strategies, control of HAI, and antimicrobial resistance
CDC
Agency responsible for conditions of participation, conditions for coverage, and tie HC quality to medical reimbursement through value based purchasing
CMS
What IP related items does CMS require?
IPC program
Antimicrobial stewardship program
IP certification board
Certification board of infection control and epidemiology (CBIC)
What does the FDA regulate?
- Drugs/ biologics for human use
- reprocessed equip
- medical devices
- antimicrobials
- PPE
- Device recall
What does the EPA regulate?
- hazardous waste and chemicals into env
- germicides applied to surfaces
This agency provides IP education, position papers, a journal, and compendium of strategies to prevent HAIs in acute care hospitals
Society of Healthcare Epidemiologists of America (SHEA)
Federal agency that protects health of Americans, and made HAIs a priority with the Roadmap to HAI elimination
U.S. Health and Human Services (HHS)
Agency that focuses on HAI innovation and implementing change
Institute of HC improvement
Accrediting agencies
The Joint Commission
DNV-GL
Regulate the types of devices used for employee protection (respirators, sharps, PPE)
National Institute for Occupational Safety and Health (NIOSH)
Regulate work related safety
Occupational Safety and Health Administration (OSHA)
IP regulations from OSHA
BBP standard of 1991, with 2001 update for sharps
General duty clause- TB
Respiratory protection standard
What should training and education be linked to?
An organizations vision, mission, and values
What are learning outcomes for HCP?
- increased competence in ID’ing problems
- critical thinking
- managing existing situations
- coping effectively with stress
Describe the adult learner
Autonomous and self-directed
Goal-oriented
Relevancy oriented
Practical
What are the three types of learning in Bloom’s taxonomy?
Cognitive- mental skills (knowledge)
Affective- growth in feelings or emotional areas (attitude of self)
Psychomotor- manual of physical skills (Skills)
Bloom’s taxonomy levels
remembering
Understanding
Applying
Analyzing
Evaluating
Creating
Can the learned recall or remember the information?
Define, duplicate, list, memorize, recall, repeat, reproduce
Remembering
Can the learner explain the ideas or concepts?
Classify, describe, discuss, explain, identify, locate, recognize, report, select, translate, paraphrase
Understanding
Can the learner use the information in a new way?
Choose, demonstrate, dramatize, employ, illustrate, interpret, operate, schedule, sketch, solve, use, write
Applying
Can the learner distinguish between the different parts?
Appraise, compare, contrast, criticize, differentiate, discriminate, distinguish, examine, experiment, questoin, test
Analyzing
Can the learner justify a stand or decision?
Appraise, argue, defend, judge, select, support, value, evaluate
Evaluating
Can the learner create new product or point of view?
Assemble, construct, create, design, develop, formulate, write
Creating
Amount that people retain by passive learning
5-30%
Amount that people retain by active learning
50-90%
Methods for active learning
Discussion group (50% retention)
Practice by doing (75% retention)
Teach others/ immediate use learning (90% retention)
Methods for passive learning
Lecture (5% retention)
reading (10% retention)
Audio-visual (20% retention)
Demonstration (30% retention)
Methods for educational needs assessment
- Learner self-assessment
- focus group
- interest finder surveys
- test development
- personal interviews
- job analysis and performance reviews
- observational studies
- review of internal reports (ie injury and illness reports)
Statements that communicate the intent of the curriculum and provide a direction for planning the education session (time and resources are defined)
Goals
Specific actions the learner will perform as a result of instruction (must be measurable and should use action verbs
Instructional objectives
Three common learning assessment tools
Koln’s learning style inventory
Dunn, Dunn, and Price Productivity Env preference survey
VARK inventory
Kolb learning style inventory- prefers concrete experience and active experimentation
Accomodative
Kolb learning style inventory- prefers abstract conceptualization and reflective observation
Assimilative
Kolb learning style inventory- prefers concrete experience and reflective observation
Divergent
Kolb learning style inventory- prefers abstract conceptualization and active experimentation
Convergent
What does the Dunn, Dunn, Price and productivity preference survey determine preferences for?
- Environmental (surroundings)
- Sociological (study alone or in groups)
- physical (visual, auditory, kinetic)
- emotional (responsibility, persistence, motivation)
Grasha teaching style: IPs use vast knowledge base to inform learners and challenge them to be well prepared. This can be intimidating to the learner
Expert
Grasha teaching style: This style puts the IP in control of the learner’s knowledge acquisition. The IP is not concerned with learner-educator relationships but rather focuses on the content to be delivered
Formal authority
Grasha teaching style: the IP coaches, demonstrates, and encourages a more active learning style
Demonstrator or Personal Model
Grasha teaching style: Learner-centered, active learning strategies are encouraged. The accountability for learning is placed on the learner
Facilitator
Grasha teaching style: The IP role is that of a consultant and the learners are encouraged to direct the entire learning project
Delegator
What should be evaluated for an IP educational program?
- appropriateness of program design
- adequacy of teaching and instructional resources
- knowledge, skills, and attitudes learned by participants
What are the evaluations?
Formative and summative evaluation
Pre/post test
Observation of practice
Exit questionnaires
Interviews
Educational evaluation conducted during the planning of the educational session to provide immediate feedback and allow appropriate changes to be made
Formative evaluation
Education evaluation that occurs after the program is completed to determine the impact and overal effectiveness
Summative evaluation
In every community, someone doses something better than their peers although they have the same resources
Positive deviance
Parts of creating a network map
- initial network
- current network
- innovation network
- project network
- potential network
- social network
Social network analysis metrics
- awareness
- connector
- integration
When is lecture appropriate
More complex, high volume topics- symposiums and panels
QA time is improtant
When is train the trainer appropraite
training large numbers of staff over short span of time
Leader guides train person responsible for implementing program and training staff
What is a leader guide for train the trainer?
Simply written goals and objectives, course outline, instructional methods, references, and evaluation
Benefits of mentoring programs
Cost-effective, cross-training
Education that may be better suited to get information to employees on night shift
Education charts
HCP IP competency framework
- Describe the role of microorganisms in disease
- Describe how microorganisms are transmitted in HC
- demonstrate std and tbp for all pt contact
- describe occ health practices to prevent acquiring infection
- Describe occ health practices that protect HCP from transmitting infection to a pt
- Demonstrate ability to problem solve and apply knowledge to recognize, contain, and prevent infection transmission
- describe the importance of healthcare preparedness for a natural or human-made infectious disease disaster
Objectives of performance improvement program
- measure how facility controls/ complies with policies
- document results observed audits
- root cause analyses
- infection rate reports –> ind physician/ unit
- benchmark against community/ state/ national
Steps to move from novice to proficient
- CIC
- Consider advanced degree in field
- serve in leadership position in local APIC chapter
Agency for HC Research Quality IP intiatives
- Improve HH
- Barrier precautions to prevent transmission
- Reduce C. diff and VRE through prudent antibiotic use
- Prevent UTIs
- Prevent CLABSI’s
- Prevent VAP
- Prevent SSI
What are the management types of power?
Coercive
Expert
Legitimate
Referent
Reward
Manager threatens with punishment
Coercive
Manager has special knowledge, experience and skills
Expert
Manager was appointed or elected
Legitimate
Manager looks to individual group members and respects community beliefs
Referent
Manger grants something a person desires or removes what they do not
reward
Agency that coordinates all federal QI efforts, key organization after to err is human
Agency for Healthcare Research and Quality (AHRQ)
What subjects require written IP polciies?
- staff and pt care practices
- construction/ renovation
- emergency management
- occupational health
- sterilization/ disinfection
6 basic functions of a manager
- plan
- organize
- staff
- lead
- control
- motivate
Deficit reduction act requires hospitals to report HAIs that are…
High/cost high/volume
secondary dx- with a higher payment dx related group
Could have been prevented
What are the staffing requirements for ambulatory care?
- at least 1 IP employed or regularly available
- develop and maintain IP and occ health programs
- sufficient supplies for std precautions
- written policies and procedures
What do most IPs spend about 50% of their time doing?
Collecting, analyzing, and interpreting data on the occurrence of infections
Steps for positive devience
- Define
- Determine
- Discover
- Design
Precede/ proceed model components
Predisoposing factors: motivate people to make change (attitudes, beliefs, values)
Enabling factors: Capacity to change (do they have the necessary skills and capability? Do they have the necessary resources?)
Reinforcing: Behavior implemented, determines whether it will continue to be carried out (Responses/ interaction of team members, supervisors, role models, own experience)
Parts of the health belief model
Perceived security/ susceptibility
Modifying factors (demographics)
Perceived threat
Cues to action (heightened awareness)
Benefits minus barriers
Self-efficacy
All: Likelihood of action
Parts of social cognitive theory
Person
Behavior
Environment
Parts of transtheoretical model/ stage theory
- Precontemplation
- contemplation
- preparation
- action
- maintenance
Which stage of transtheoretical approach: mixed communications to highlight the problem of infection spread in hc settings
Precontemplation stage
Which stage of transtheoretical approach: communications and role modeling to show advantages, minimize disadvantages of best practice
Contemplation stage
Which stage of transtheoretical approach: ID resources and provide training for best practice techniques
Preparation group
Which stage of transtheoretical approach: coaching, training, reinforcing self-efficacy to master best practices, provide social reinforcement
Action group
Which stage of transtheoretical approach: Continue reinforcement, peer support, highlighting best practice compliance in small group settings
Maintenance group
Goals of SSI surveillance plans
- ID risk factors for infection and adverse events
- implement risk reduction measures
- monitor effectiveness of interventions
What to review in SUD site-visit
- Policies
- Cleaning and decontamination
- inspection and testing
- sterilization load prep process
- quality control measures
Pneumatic tube spill processes
- method to recognize spills/ leaks
- communication protocol
- cleaning and decontamination
- retrieval of stuck items
- restoration system
Process for SPD if single positive indicator is in a load with no implants
Check log- used correctly?
Contact maintenance
Test again- 3 consecutive cycles with paired BI from dif manufacturers
Maintenance of refrigerator/ freezers
- compare features to match intended use
- accurate temp monitoring (+ test accuracy)
- record temp reg basis
- routine monitoring of alarms
- reg preventative maintenance
- keep humidity low in walk-in units
- train personnel on safe maintenance
How can IP support antimicrobial stewardship?
- calculate MDRO incidence based on clinical culture results
- Calculate MDRO infection rates
- Use molecular typing for investigating outbreaks
- detect asymptomatic carriers using active surveillance cultures
Incubation period pneumonic plague
2-4 days (1-6 days)
Pneumonic plague precautions
droplet until 48 hours after appropraite antimicrobials and clinically improving
SSI score components- what makes up risk index score
+1: asa of 3,4, or 5
+1: operation classified as contaminated/ dirty/ infected
+1: operation lasts longer than duration cut pt time in minutes
How to test for anthrax
- measure antibodies or toxin in blood
- test for B. antrharics in blood, skin, CSF, or resp secretions
What is included in the budget/
- planned sales/ revenue
- Resource quantities
- costs and expenses
- assets
- liabilities
- cash flow
What makes a good performance measure
- evidence-based
- well defined
- clinically important for patient populations
- broadly applicable in dif types of facilities
Ideal active/ passive education ratio
60/40
What should goals and objectives in the annual risk assessment be based off of?
- strategic goals
- data and findings of previous year
- resources and data system needs
- reviewed in context of goals
Used to measure efficiency of production, measures output:inputs
productivity
3 things that performance improvement focuses on
- clinical outcomes
- customer service
- customer satisfaction
How long is bleach in a spray/ brown opaque bottle stable for?
30 days and retain 50% concentration
How short-term IVDs get infected
- cutaneous
- extraluminal
- occasionally intraluminal
How long-term IVDs get infected
- contamination catheter hub
- luminal fluid
Process for sentinel surveillance
Collect data from sample of reporting sites
Example- monitoring chickens for antibodies to arboviruses
What type of data can a run chart be used with?
Any numeric data (discrete or continuous)
IP for CRE
- Rapidly ID pts with CRE and put on TBP
- use antibiotics wisely
- minimize device use
- Surveillance- focus on high-risk settings or pts at high risk or from high risk setting
How PFGE works and what it is used for
Lyses organism
Restricts enzymes to digest DNA (fragments)
Fragments- pattern discrete bands
Bar code bacterial chromosome
Used to assess relatedness of different clinical isolates
Describe discrete data
Categorical or noncategorical
Whole #s, mutually exclusive
Example: infected/ not infected, male/ female
Describe noncategorical data
Can count events, but not non-events
Ex) patient falls/ 1000 pt days
Describe categorical data
Counts events and non-events
Ex) 10 SSIs in 100 surgical cases = 10 events, 90 non-events
Describe continuous data
Numeric values between the minimum and maximum
Ex) age, serum cholesterol level
Measurements
What does the RCA determine?
- human and other factors
- process of systems involved
- underlying causes/ effects of process
- risks and potential contributions to failure or adverse events
Steps to an initial OB investigation
- confirm outbreak present
- alert key partners
- lit review
- preliminary case definition
- methodology for case finding
- initial line list/ epi curve
- observe and review potentially implicated pt care activities
- Consider env sampling
- implement initial control measures
Conducting the needs assessment ID deficiencies in….
- knowledge
- skills
- attitudes
How is surveillance used?
- ID risk factors of infections and adverse events
- implement risk reduction measures
- monitor effectiveness of interventions
Human factor limitations that contribute to error:
- limited memory capacity
- negative effects of stress
- negative influence fatigue
- overdependence on multitasking
5 TJC IP standards
- Minimize HAI risk through IP program
- ID risk of transmission of infectious agents
- Effective management of the IP program
- collaboration relevant roles and functions
- adequate resources
Describe the model for improvement
Part 1:
1. set aims
2. establish measures
3. select changes that will make improvement
Part 2:
test changes in PDSA
What are the outcomes for low nurse staffing levels?
Increased:
- pneumo
- shock
- cardiac arrest
- UTI
Increase in non permanent staff leads to increase in HAIs
List of HAIs, most common to least common
- Pneumo
- SSI
- GI
- UTI
- BSI
Top HAI organisms, from most common to least common
- C. Diff
- Staph
- Klebsiella
- E coli
- Enterococcus
- Pseudomonas
What is included in a business plan?
- set of business goals
- reasons goals are attainable
- plan to reach the goals
What are the goals of human factors engineering?
Minimize errors by:
- improving efficiency
- creativity
- productivity
- job satisfaction
What law requires meaningful use of EHR?
American Recovery and Reinvestment Act
Failure of planned action to be completed as intended or use of wrong plan to achieve an aim
Medical error
Serious, undesirable, unanticipated pt safety event that resulted in harm to the patient
Adverse event
Event that results in death, permenant harm, or severe, temporary harm
Sentinel event
Common causes of medical errors
- communication problems
- inadequate info flow
- human probelms
- pt related issues
- org transfer knowledge
- staffing patterns/ workflow
- tech failures
- inadequate policies and procedures
Standardized terminology and classification schema for near misses and adverse events
Public safety taxonomy
What are the patient safety event taxonomy classifications:
- impact
- type- implied of visible processes that were faulty or failed
- domain- characteristic of setting in which incident occurred, type of ind involved
- cause
- prevention
Within how many days of an event does the RCA have to be completed?
45 days
Systematic study of elements involving human-machine interface with the intent of improving working conditions or operations
Human factors analysis
Research in human pysch, social, physical, and biologic characteristics, concerned with design of tools, machines, and systems that consider human capabilities, limitations, and characteristics
Human Factors Engineering
Recognizes complex, high technology systems are subject to rare but usually catastrophic organizational accidents in which variety of contributing factors combine to breach safeguards and some accidents could be thwarted if front line acquired degree mindfulness about failure points
Error wisdom
Reasons for error types in error wisdom
- skill based (slip or lapse)
- rule based (how taught)
- knowledge based (new situation)
Study of a process to achieve a failure free operation over time to reduce process defects and improve system safety. Includes resilience
Reliability science
Intrinsic ability of system to adjust and sustain operations during periods of stress or after an event
resilience
5 Principles of reliability science
- preoccupation with failure
- sensitivity to operations (awareness of changes like changes in the community may impact need for care)
- reluctance to simplify (multidisciplinary)
- Commitment to resilience
- deference to expertise
Parts of FMEA
- Failure- lack of success, nonperformance, etc
- Mode- way failure occurs, impact on a process
- Effect- consequences
- Analysis- possible failure modes and effects, how serious are the effects?, how to eliminate or reduce failure to prevent harm
Set of values, guiding beliefs, or ways of thinking that are shared among members of an organization, feel of the organization that is quickly picked up by new members
Culture
Patient safety culture: why waste time on safety?
Pathological
Patient safety culture: Do something when there is an incident
Reactive
Patient safety culture: Systems in place to manage all identified risks
Bureaucratic
Patient safety culture: always on alert for risks that might emerge
Proactive
Patient safety culture: risk management is an integral part of everything we do
Generative
What makes a strong safety culture?
- generative
- uneasy about risk
- constantly seek best practices
- look for where next mistake will happen
- work to prevent next mistake
Everyone holds each other accountable for patient safety
Reciprocal accountability
Science of studying people at work then designing tasks, jobs, information, tools, equipment, facilities, and the working env so that ppl can be safe, productive, and comfortable
Ergonomics
What do HCP want after they are involved with a patient safety event?
- system assessment
- support of colleagues
- sense of shared responsibility with leadership
- preventative action plan
- commitment to fix system problems
- psych counseling
Sets direction for where organization will go in the future, and what the organization must do to reach goal. mission, or vision
Strategic Plan
What are TJC requirements for the IP strategic plan
- Prioritize the ID’d risk for acquiring and transmitting infections
- Set goals that limit:
- Unprotected exposure to pathogens
- transmission of infections associated with procedure
- transmission of infections associated with medical equipment, devices, and supplies - describes activities and surveillance to minimize, reduce, or eliminate risk of infection
- describes process to evaluate efficacy of plan
Part of multi-disciplinary quality concept team- expert on team process, not process under review
Facilitator
Part of multi-disciplinary quality concept team- manager with process knowledge
Team leader
Part of multi-disciplinary quality concept team- front line employees
team members
Steps for failure mode effect analysis
- determine process to study (high risk of harm)
- multi-disciplinary team’
- Flow diagram with each step of process and subprocess
- Reasons process may fail and likert scale with severity and probability
- redesign process to eliminate failure
- develop outcome measure to redesign process
Parts of the six sigma/ lean approach
Define
Measure
Analyze
Improve
Control
Number of data points that run chart is best for
<25
Number of data points control chart is best for
25-50
valid and reliable indicator that can be used to monitor and evaluate quality of functions that affect patient outcomes
measure
Does it measure what it’s intended to measure?
valid
Does it accurately and consistently ID events it is intended to ID across multiple HC settings?
Reliable
Tool that provides an indication of organizations performance in relation to a specified process or outcome
Performance measure
Performance measure designed to evaluate the processes or outcomes of care associated with delivery of clinical services (condition specific, procedure specific)
Clinical measure
Measure that indicates result of performance
Outcome measure
What should be considered for outcome measures?
- cost/ benefit
- pt satisfaction
Ex- clean needle exchange or pt dissatisfaction with iso
Measure that evaluates compliance with pt care activities
Process measure
What measure is best for uncommon outcomes?
Process measure
Chart for when comparing relationship between points is more important than the exact values of the data points
Bar graph
Best chart for how categories relate to each other with respect to a whole
Pie chart
Diseases seen in neutropenia from HSCT patients
Gram negative aerobes
Gram positive cocci
Candida
Aspergillus
Hsv
Diseases seen in neutropenia from HSCT patients
Gram negative aerobes
Gram positive cocci
Candida
Aspergillus
Hsv
Diseases seen hsct patients with cell mediated immunity
- Viruses (CMV, EBV, adenovirus, EBV, resp viruses)
- Intracellular facultative bacteria (listeria, mtb, etc)
- fungi- pneumocystis jerovecii
- protozoa - toxo
Diseases seen hsct patients with cell mediated immunity
- Viruses (CMV, EBV, adenovirus, EBV, resp viruses)
- Intracellular facultative bacteria (listeria, mtb, etc)
- fungi- pneumocystis jerovecii
- protozoa - toxo
Diseases seen in hsct patients with humoral immunity dysfunction
Encapsulated bacteria
O
Tjc standards
- Minimize the risk for development of an hai through an organization-wide infection prevention program
- Identify risk for the acquisition and transmission of infectious agents on an ongoing basis
- Effective management of the infection prevention and control program
- Collaboration of representatives from relevant components and functions within the organization in the implementation of the program
- Allocation of adequate resources to the infection prevention and control program
Tjc standards for ip program
- Minimize the risk for development of an hai through an organization-wide infection prevention program
- Identify risk for the acquisition and transmission of infectious agents on an ongoing basis
- Effective management of the infection prevention and control program
- Collaboration of representatives from relevant components and functions within the organization in the implementation of the program
- Allocation of adequate resources to the infection prevention and control program
Organizations process of defining its strategy or direction and making decisions on allocating its resources to pursue this strategy
Strategic planning
Organizations process of defining its strategy or direction and making decisions on allocating its resources to pursue this strategy
Strategic planning
What does the strategic planning process include?
Setting goals, determining actions to achieve the goals, and mobilizing resources to execute the action
Planned objectives that a department or organization strives to achieve they must be clear and measurable
Strategic goals