Chemotherapeutic Agents ulit Pt. 3 Flashcards
The ___________________________________ attacks the helper T cells (CD4 cells) within the immune system.
human immunodeficiency virus (HIV)
NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
delavirdine (Rescriptor), efavirenz (Sustiva), etravirine (Intelence), and nevirapine (Viramune) and rilpivirine (Edurant)
They prevent the transfer of information that would allow the virus to carry on the formation of viral DNA
NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
abacavir (Ziagen), didanosine (Videx), emtricitabine (Emtriva), lamivudine (Epivir), stavudine (Zerit XR), tenofovir (Viread), and zidovudine (Retrovir)
compete with the naturally occurring nucleosides within the cell that the virus would use to build the DNA chain
NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
compete with the naturally occurring nucleosides within the cell that the virus would use to build the DNA chain
zidovudine
PROTEASE INHIBITORS
atazanavir (Reyataz), darunavir (Prezista). fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (Kaletra), nelfi navir (Viracept), ritonavir (Norvir), saquinavir (Fortovase), and tipranavir (Aptivus).
block protease activity within the HIV virus
PROTEASE INHIBITORS
is essential for the maturation of an infectious virus; without it, an HIV is immature and noninfective.
Protease
intended to target the abnormal cells that compose the neoplasm or cancer
ANTINEOPLASTIC AGENTS
start with a single cell that is genetically different from the other cells in the surrounding tissue. eventually producing a tumor or neoplasm
Cancer
originated from mesenchyme and are made up of embryonic connective tissue cells
SARCOMA
originated from epithelial cells
CARCINOMA
ALKYLATING AGENTS
altretamine (Hexalen), bendamustine (Treanda), busulfan (Busulfex, Myleran), carboplatin (Paraplatin), carmustine (BiCNU, Gliadel), chlorambucil (Leukeran), cisplatin (Platinol-AQ), cyclophosphamide (Cytoxan, Neosar).
produce their cytotoxic effects by reacting chemically with portions of the RNA, DNA, or other cellular proteins, most potent when they bind with cellular DNA.
ALKYLATING AGENTS