Antipsychotics

Question 1

2 Types of Antipsychotics

Answer 1

First generation (typical)
Second generation (atypical)

Question 2

they block dopamine receptors in the brain leading to decreased dopaminergic neurotransmission

Answer 2

Antipsychotics

Question 3

Extrapyramidal side effects of First Generation Antipsychotics

Answer 3

acute dystonia
akithisia
akinesia
tardive akinesia

Question 4

First Generation Antipsychotics

Answer 4

Chlorpromazine
Fluphenazine
Haloperidol

Question 5

SGAs typically has more metabolic side effects such as:

Answer 5

weight gain
diabetes
hypercholesterolemia

Question 6

Second Generation Antipsychotics

Answer 6

Clozapine
Olanzapine
Asenapine
Lurisidone
Ziprazidone
Risperidone
Paliperidone
Sulpiride

Question 7

first SGA introduced into the market

Answer 7

Clozapine

Question 8

Although considered the most effective antipsychotic, it is not first line due to small chance of the dangerous side effects such as agranulocytosis and cardiac toxicity

Answer 8

Clozapine

Question 9

Clozapine, although considered the most effective antipsychotic, it is not first line due to small chance of the dangerous side effects such as

Answer 9

agranulocytosis and cardiac toxicity

Question 10

partial agonist at dopamine D2 receptor

Answer 10

Aripiprazole

Question 11

Distrupt areas of brain where dopamine acts strongly on these receptors leading to decreased response (response is greater than antagonists)

Answer 11

Aripiprazole

Question 12

a phenothiazine antipsychotic, primarily acts by blocking D2 dopamine receptors in the brain, particularly in the mesolimbic and mesocortical pathways, reducing symptoms of psychosis like hallucinations and delusions. It also inhibits dopamine in the chemoreceptor trigger zone (CTZ), providing effective relief from nausea and vomiting. Additionally, its H1 histamine receptor blockade produces sedative effects, aiding in the management of agitation.

Answer 12

Chlorpromazine

Question 13

works primarily by blocking dopamine (D2) receptors in the brain. This action reduces the symptoms of psychosis such as hallucinations, delusions, and agitation. It is considered a first- generation (typical) antipsychotic with potent dopamine antagonism, which is effective in managing psychiatric symptoms but also associated with a higher risk of extrapyramidal side effects (EPS) compared to atypical antipsychotics.

Answer 13

Haloperidol