Chemo

Question 1

What is chemotherapy

Answer 1

Compounds targeting DNA, RNA and proteins

Question 2

Is chemotherapy specific or non specific?

Answer 2

Non specific

Question 3

What is the aim of chemotherapy?

Answer 3

To force cells into apoptosis

Question 4

What are the 3 main types of chemotherapy?

Answer 4

• Alkylating agents and platinum drugs
• Antimetabolites
• Organic drugs

Question 5

Describe the mechanism alkylating agents and platinum drugs

Answer 5

Form DNA adducts blocking DNA replication (all phases of Cell cycle)

Question 6

Describe the mechanism of antimetabolites

Answer 6

Structurally mimic essential molecules required for cell division (S phase of cell cycle)

Question 7

What are the 3 classes of organic chemotherapy

Answer 7

Vinca alkoids
Taxanes
Anthracyclines

Question 8

Describe the mechanism of vinca alkaloids

Answer 8

Bind to tubular and prevent microtubule assembly

Question 9

Describe the mechanism of taxanes

Answer 9

Bind to beta tubular subunit inhibiting depolymerisation and disrupting mitotic spindle

Question 10

Describe the mechanism of anthracyclines

Answer 10

Microbial antibiotic targets topoisomerase II

Question 11

What are the hormone releasing cancers

Answer 11

Breast 
Endometrium
Ovarian
Prostate
Testes
Thyroid

Question 12

What do immune checkpoints ensure?

Answer 12

That self tolerance is maintained