ACS - presentation and management Flashcards

1
Q

What is ACS

A

New onset of a collection of symptoms related to a problem with the coronary arteries

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2
Q

What do the CA supply?

A

Myocardial cells

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3
Q

What does an ACS cause?

A

Myocardial Ischaemia

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4
Q

What is stable angina caused by?

A

‘Stable’ Coronary leison

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5
Q

What are stable anginal symptoms relieved by?

A

Rest

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6
Q

What are acute coronary syndromes caused by?

A

Unstable coronary leison

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7
Q

How do you diagnose ACS?

A

Detection of cardiac cell death (troponin) AND:

  • Symptoms of ischaemia
  • New ECG changes
  • Evidence of coronary problem on coronary angiogram or autopsy
  • Evidence of new cardiac damage on another test
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8
Q

What is a type 1 MI?

A

Spontaneous MI associated with ischamia and due to a primary coronary event such as plaque erosion, rupture, fissuring or dissection

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9
Q

What is a type 2 MI?

A

Due to imbalance in supply and demand of oxygen. Result of Ischaemia but not ischaemia from thrombosis of CA

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10
Q

What is a type 3 MI?

A

Sudden cardiac death, Including cardiac arrest, with symptoms of ischaemia, accompanied by new ST elevation or LBBB. Verified coronary thrombus by angiography or autopsy but death occurring before blood samples could be obtained or before biomarkers appear in the blood

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11
Q

What is a type 4a MI?

A

MI associated with PCI. PCI related crease of biomarkers greater than X 99th percentile of the upper reference limit is by convention defined as MI

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12
Q

What is a type 4b MI?

A

MI associated with verified statement stent thrombosis via angiography or autopsy

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13
Q

What is a type 5 MI?

A

MI associated with CABG, >5 x99th percentile upper reference limit plus new Q waves or LBB or imaging of new loss

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14
Q

What does LBBB stand for?

A

Left bundle branch block, - a cardiac conduction abnormality seen on the electrocardiogram (ECG). In this condition, activation of the left ventricle of the heart is delayed, which causes the left ventricle to contract later than the right ventricle

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15
Q

What type of MI would a vasospasm or endothelial dysfunction be?

A

MI Type 2

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16
Q

What type of MI would a fixed atherosclerosis and supply-demand imbalance by?

A

MI Type 2

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17
Q

What type of MI would be a plaque rupture with thrombus be?

A

MI Type 1

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18
Q

What type of MI would be a supply-demand imbalance alone?

19
Q

Describe the history of a patient with a STEMI?

A
  • Ischaemic sounding heart pain
  • May radiate to neck/arm
  • OFten deny it is a ‘pain’, more of a ‘discomfort, weight or tightening’
  • May be associated with nausea, sweating and breathlessness
20
Q

What does the initial ECG of a person with a complete coronary occlusion show?

A

ST elevation?

21
Q

What does the ECG at 3 days show after a complete coronary occlusion?

22
Q

what does the initial ECG of a partial coronary occlusion show?

A

ST depression
T wave inversion
May be normal

23
Q

What does the mECG of a partial coronary occlusion at 3 days show?

A

No Q waves

24
Q

What may show/not be shown on an ECG of a posterior MI

A

As the posterior wall supplied by the left circumflex artery may not see any ST elevation anywhere, even if LCx is completely blocked

25
If a posterior MI is suspected what investigation is reccomended?
Put ECG leads on back of chest - will see opposite changes in leads however
26
What is the goal of reperfusion therapy?
To open a blocked artery
27
What is a mechanical reperfusion therapy?
PCI
28
What is a pharmacological reperfusion therapy?
Thrombolysis
29
What are the risks of thronbolysis?
Bleeding
30
When to not give thrombolysis
If recent stroke, or ever had a previous intracranial bleed | Caution if had recent surgery, on warfarin, or severe hypertension
31
How to decide if thrombolysis or cath lab for stemi?
If you can get to cath lab within 2 hours, then dont give thrombolysis
32
What are the investigations for an NSTEMI?
``` Serial ECG's - As to not miss an evolving STEMI or a posterior STEMI Blood tests - Troponin - Cholesterol levels ```
33
What are the possible treatment options for an ACS with no ST elevation?
``` GTN Opiates Antithrombotic drugs with a P2Y12 antagonists Anticoagulant drugs Beta blockers Statins ACEI ```
34
GTN effects
Vasodilator - opens up CA | - Wont help if artery is completely blocked
35
How can GTN be given?
Sub-lingual or as IV
36
Opiate (morphine) effects
Helps relieve anxiety | Helps venodilate which may have haemodynamic benefits
37
Describe the procedure of dual antiplatelet therapy for an NSTEMI
``` Aspirin PLUS ONE OF P2Y12 Receptor antagonists: - Clipiodogrel - Tricagrelor - Prasugrel ```
38
Describe the dosing of aspirin?
300mg loading dose - unless already on, then 75mg
39
Describe the dosing of clopidogrel?
300mg loading dose, then 75g
40
Describe the dosing of tricagrelor?
180mg loading dose, then 90mg
41
Describe the dosing of prasugrel
60 mg loading dose, then 10mg
42
What is the effect of anti-coagulant drugs?
Prevent fibrin formation
43
What procedure is given to those with NSTEMI unless frail/elderly?
Coronary angiogram
44
What is the management for someone with a NSTEMI
- Keep attached to a cardiac moniter for first 24-48 hours - Listen to new murmurs and signs of heart failure every day - Start 'secondary prevention' medication - Do an echo