Chapter 8 Flashcards

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1
Q

Metabolism definition

A

Sum total of all chemical reactions occurring in a biological system at a given time

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2
Q

What do cells use energy to do?

A

To grow, reproduce, maintain their structure, respond to environmental changes

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3
Q

Major theme is biology

A

Life requires energy transfer and transformation

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4
Q

Two distinct divisions of metabolism

A

Catabolic reactions (catabolism) and anabolic reactions (anabolism)

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5
Q

Catabolism definition

A

Release energy by breaking down complex molecules into smaller compounds ; downhill reaction

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6
Q

Anabolism definition

A

Consume energy to build complex molecules from simpler ones ; uphill reaction

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7
Q

What are metabolic pathways?

A

Series of chemical reactions occurring within a cell

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8
Q

Metabolic pathway reactions are ____________ , where the product _____

A

Catalyzed by enzymes ; the product of one enzyme acts as the substrate for the next

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9
Q

Feedback Inhibition definition

A

When the product of a pathway acts as an inhibitor of the pathway to prevent too much build up of a product

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10
Q

Spontaneous Reactions

A

Occurs without any requirement for outside energy, but it may occur so slowly that it is imperceptible

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11
Q

What kind of reaction is hydrolysis of sucrose

A

Exergonic and spontaneous reaction ; very very slow reaction

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12
Q

Free-Energy Change (∆G) Definition

A

Tells us whether the reaction occurs spontaneously

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13
Q

Free-Energy Change Equation

A

∆g= ∆H-T ∆S

∆=change
G=Gibb’s Free Energy
H= Total Energy
T= Absolute Temperature (k)
S= Entropy

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14
Q

When is ∆G spontaneous and when is energy required?

A

∆G < 0 = Spontaneous

∆G > 0 = Energy Required

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15
Q

What does more free energy equal (higher G)?

A

More energy, less stable, greater work capacity

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16
Q

What does less free energy equal (lower G)?

A

Less energy, more stable, less work capacity

17
Q

What can catalyst reactions?

A

Enzymes can catalyst a reaction but are not used up in the reaction ; only connect to certain substrates

18
Q

What impacts enzymatic activity? (5)

A

Temperature, pH, Cofactors, Competitive Inhibitors, Noncompetitive Inhibitors

19
Q

How does temperature impact enzymatic activity?

A

As temp, increases, reaction rate will increase ; Enzymes have a peak performance at a temp, optimum ; Beyond that they denature

20
Q

How does pH impact enzymatic activity?

A

Most enzymes have a pH at which they perform at peak efficiency - the pH optimum

21
Q

How do cofactors impact enzymatic activity?

A

Non-protein enzyme helpers ; Cofactor may be inorganic but can also be organic

22
Q

How do competitive inhibitors impact enzymatic activity?

A

Bind to active site of enzyme, competing with substrate for binding to the exact same site (decreases productivity)

23
Q

How do noncompetitive Inhibitors impact enzymatic activity?

A

Bind to another part of the enzyme, causing the enzyme to change shape, making the active site less effective

24
Q

What do allosteric sites do?

A

They bind ATP and AMP

25
Q

Which is an inhibitor and which is an enhancer, ATP and AMP?

A

ATP is an inhibitor and AMP is an enhancer

26
Q

What happens when ATP production is greater than use?

A

The ATP will accumulate and then slow of shut off pathway

27
Q

What happens when ATP production is behind?

A

ATP will accumulate and enhance the pathway

28
Q

What is a coupled reaction?

A

Couple a spontaneous reaction to a non-spontaneous reaction ; Uses exergonic reaction to drive endergonic reactions

29
Q

What happens in an oxidation reaction?

A

Cells release (catabolism) the energy in their food molecules through a series of oxidation reactions (cellular respiration)

30
Q

What happens to electrons in an oxidation reaction?

A

Electrons are transferred from one molecule to another changing in composition and energy content of both the donor and acceptor molecules ; energy generated is stored at ATP and NADH

31
Q

What kinds of things does ATP do?

A

Powers cellular work by coupling reactions ; Drives endergonic reactions by phosphorylation (transferring a phosphate group to some other molecule)

32
Q

Three types of cellular work

A

Chemical, transport, mechanical

33
Q

What is chemical cellular work?

A

ATP phosphates key reactants

34
Q

What is transport cellular work?

A

ATP phosphates transport proteins

35
Q

What is mechanical cellular work?

A

ATP phosphates motor proteins