Chapter 5: Nutritional Needs Flashcards
Chronic disease related malnutrition with inflammation is also known as
Cachexia
Effect of systemic inflammation on protein metabolism
-changes in protein synthesis & degradation
-loss of fat & muscle mass
-increase in acute-phase proteins (aka CRP)
Effect of systemic inflammation on carbohydrate metabolism
Insulin resistance and impaired glucose tolerence
Effect of systemic inflammation on lipid metabolism
maintained or increased lipid oxidation (d/t free radicals), particularly in the presence of weight loss
Individuals with cancer are at risk for loss of muscle mass resulting from two conditions
- Sarcopenia (age related muscle breakdown)
- Cachexia
These 7 cancers have found to be hypermetabolic
- pancreatic
- gastric
- bile duct
- kidney
- adrenal
- NSCL
- H&N
There is controversy amongst advanced cancers and if they may be hypermetabolic or hypometabolic. What about metastatic cancer to the liver?
Hypermtabolic
These 3 cancers are considered normometabolic
- breast
- colorectal
- bladder
The Dietary Reference Intakes are developed for ___________ but cannot be used to ensure adequacy for __________
Groups
Individuals
*Use a reference point or approximation
Protein needs for individual with cancer
1-1.5 g/kg
Protein needs for cancer cachexia
1.5-2.5 g/kg
Protein needs for hematopoietic stem cell transplant
1.5 g/kg
Protein needs for healthy young adult
0.8 g/kg
ADMR: 10-35%
Protein needs for healthy older adult
1.0-1.2 g/kg
Protein needs for acutely ill or chronically ill older adult
1.2-1.5 g/kg
Nitrogen balance can be used to assess
Adequacy of recommended protein values
RDA for carbohydrates
130 g/day
ADMR: 45-65%
RDA for fats
None set, but need for essential fatty acids can usually be met when linoleic & linolenic acid provide 2-4% of total intake
ADMR: 20-35%
Cisplatin in a ______toxic chemotherapy
Nephrotoxic
3 methods used to calculate fluid needs
- Weight (Holliday-Segar)
- Body surface area
- RDA
RDA method for calculating fluid needs
1 mL/kcal
Body surface area calculation
1500 mL x BSA
Weight (Holliday-Segar) method calculation
0-10 kg = 100 mL/kg
10-20 kg= 1000 mL + 50 mL for each kg over 50
>20 kg
- </= 50 years old, 1500 mL + 20 mL for each kg over 20 kg
- > 50 years old, 1500 mL + 15 mL for each over 20 kg
5 conditions that increase fluid requirements
- Fever
- Sweating
- Hyperventilation
- Hyperthyroidism
- Gastric or renal losses
Levels of these 4 nutrients are not usually lowered in the presence of inflammation (thus low levels may = deficiency)
*b strong
- Thiamine
- Riboflavin
- Folate (B9)
- Vitamin B12
Levels of these 4 nutrients are lowered during the inflammatory process
- Selenium
- Copper
- Iron
- Zinc