Chapter 4 - Neurotransmitter Systems Flashcards
In what two regions are cholinergic neurons found?
Pontomesencephalic
Nuclear groups of the BF
What is the primary efferent NT of the PNS?
Acetylcholine
What classes of drugs have strong anti cholinergic properties?
Antihistamines
First gen antipsychotics
Tricyclics antidepressants
Where do andrenergic neurons exist primarily?
Locus coerulus
Lateral tegmental area of pons and Medulla
What role does NE play?
Modulating sleep-wake cycles Attention Mood Pain
What ADHD meds increase NE and DA?
Ritalin
Concerta
Adderall
What ADHD med is a SNRI?
Strattera
Where are serotonergic neurons found?
Raphe nuclei of midbrain, pons, and medulla
Where do the rostral raphe project to?
Entire forebrain including thalamus, cortex, and basal ganglia
Where do the dorsal raphe project to?
Cerebellum, medulla, spinal cord
What med is a 5-HT and NA re uptake inhibitor?
Effexor (venlafaxine)
What are two serotonin 2A antagonists?
Trazodone (Desryl)
Mirtazapine (Temeron)
Where do DA containing neurons exist primarily?
SNpc
VTA
What are three DA subsystems?
Mesostriatal
Mesolimbic
Mesocortical
From where does the mesostriatal system arise and project?
Arises:
SNpc
Projects:
Striatum (caudate and putamen)
