Chapter 30 - Movement Disorders

Question 0

What is the role of the extrapyramidal motor system?

Answer 0

Regulates movement
Muscle tone
Posture

Question 1

What structures are part of the extrapyramidal motor system?

Answer 1

Basal ganglia, STN, SN, thalamic nuclei

Question 2

What neuro anatomical region experiences a loss of DA cells in PD?

Answer 2

SN (lateral ventral)

Question 3

What neuro anatomical region shows the largest depletion of DA in PD?

Answer 3

Dorsolateral putamen

Question 4

When what are the main sx of PD, cognitive deficits tend to occur more frequently?

Answer 4

Bradykinesia and rigidity

Question 5

What are two common DA agonists used to tx PD?

Answer 5

Requip

Miripex

Question 6

Onset of compulsive behaviors is a potentially devastating side effect of what med used to tx PD?

Answer 6

DA agonists

Question 7

What are two primary targets of DBS in PD?

Answer 7

STN and GP

Question 8

DBS if what structure results in improved tremor?

Answer 8

Ventrointermedius thalamic nuclei

Question 9

What kind of neuro degenerative disorder is Huntington’s disease?

Answer 9

Terminal autosomal dominant

Question 10

What are the genetics differences in HD?

Answer 10

CAG repeats on chromosome 4

Question 11

What are the four core motor sx of HD?

Answer 11

Chorea
Bradykinesia
Dystonia
In coordination

Question 12

What is the neuropathology seen in HD?

Answer 12

Loss of medium spiny neurons in the caudate nucleus