Chapter 38: Antibiotics Flashcards
Which class of penicillin (PCN) affects bacteria with pseudomonal activity?
Extended spectrum
Piperacillin is used for patients with…
Intraabdominal infection with pseudomonas aeruginosa
Cephalosporin is excreted through
Kidney
Oral vancomycin is used for which bacterium?
C Diff.
Which antibacterial is in the lincosamide class?
Clindamycin
What is the half life of clindamycin?
Half life is 2-3 hours. Therefore, it must be administered everyday 6 hours to have therapeutic effects
Why is gentamicin given intravenously instead of orally?
Gentamicin is not absorbed orally.
What makes gentamicin nephrotoxic?
A small amount of gentamicin is reabsorbed in the renal cortex which increases risk for nephrotoxicity
Which abx are effective against pseudomonas aeruginosa?
Ciprofloxacin
Gentamicin
Which cardiac medication is Cipro contraindicated with and why?
Cipro cannot be taken with Beta Blockers because it can prolong the QT intervals causing arrhythmia
Ceftriazone can cause ____ ____ if combined with an anticoagulant.
Excessive Bleeding
When giving multiple doses of gentamicin, what lab tests should be assessed?
Trough levels. Because high trough levels indicates drug toxicity
Which 3 abx work against Pseudomonas Aeruginosa?
Piperacillin
Ceftriaxone
Cecepime
Oxacillin antibiotic treats_____
Cardiac infection with staph.
Amoxicillin is NOT prescribed for ____
Asthma and throat infection
Which cephalosporin would be administered for treatment of MRSA?
Ceftaroline
Why is Cilastatin given with Imipenem?
Cilastatin prevents renal metabolism of imipenem.
Clindamycin cannot be given to a patient with advanced ____ _____.
Advanced liver disease
Which abx work against E. Coli?
Sulfonamide
Aminoglycoside
Fluoroquinolone
Pharmacokinetics of tetracycline.
Absorption decreases as the dose is increased.
Tetracycline is the first line therapy for ____.
H. Pylori
Which abx has protein binding of less than 40%
Gentamicin
Ciprofloxacin
Which type of drugs can cause nephrotoxicity when administered with Vancomycin?
NSAIDs
Erythromycin can cause ____ of the ears
Ringing of the ears.
Gentamicin can cause N____ and O______
Nephrotoxicity and Ototoxicity
