Chapter 38: Antibiotics

Question 1

Which class of penicillin (PCN) affects bacteria with pseudomonal activity?

Answer 1

Extended spectrum

Question 2

Piperacillin is used for patients with…

Answer 2

Intraabdominal infection with pseudomonas aeruginosa

Question 3

Cephalosporin is excreted through

Answer 3

Kidney

Question 4

Oral vancomycin is used for which bacterium?

Answer 4

C Diff.

Question 5

Which antibacterial is in the lincosamide class?

Answer 5

Clindamycin

Question 6

What is the half life of clindamycin?

Answer 6

Half life is 2-3 hours. Therefore, it must be administered everyday 6 hours to have therapeutic effects

Question 7

Why is gentamicin given intravenously instead of orally?

Answer 7

Gentamicin is not absorbed orally.

Question 8

What makes gentamicin nephrotoxic?

Answer 8

A small amount of gentamicin is reabsorbed in the renal cortex which increases risk for nephrotoxicity

Question 9

Which abx are effective against pseudomonas aeruginosa?

Answer 9

Ciprofloxacin
Gentamicin

Question 10

Which cardiac medication is Cipro contraindicated with and why?

Answer 10

Cipro cannot be taken with Beta Blockers because it can prolong the QT intervals causing arrhythmia

Question 11

Ceftriazone can cause ____ ____ if combined with an anticoagulant.

Answer 11

Excessive Bleeding

Question 12

When giving multiple doses of gentamicin, what lab tests should be assessed?

Answer 12

Trough levels. Because high trough levels indicates drug toxicity

Question 13

Which 3 abx work against Pseudomonas Aeruginosa?

Answer 13

Piperacillin
Ceftriaxone
Cecepime

Question 14

Oxacillin antibiotic treats_____

Answer 14

Cardiac infection with staph.

Question 15

Amoxicillin is NOT prescribed for ____

Answer 15

Asthma and throat infection

Question 16

Which cephalosporin would be administered for treatment of MRSA?

Answer 16

Ceftaroline

Question 17

Why is Cilastatin given with Imipenem?

Answer 17

Cilastatin prevents renal metabolism of imipenem.

Question 18

Clindamycin cannot be given to a patient with advanced ____ _____.

Answer 18

Advanced liver disease

Question 19

Which abx work against E. Coli?

Answer 19

Sulfonamide
Aminoglycoside
Fluoroquinolone

Question 20

Pharmacokinetics of tetracycline.

Answer 20

Absorption decreases as the dose is increased.

Question 21

Tetracycline is the first line therapy for ____.

Answer 21

H. Pylori

Question 22

Which abx has protein binding of less than 40%

Answer 22

Gentamicin
Ciprofloxacin

Question 23

Which type of drugs can cause nephrotoxicity when administered with Vancomycin?

Answer 23

NSAIDs

Question 24

Erythromycin can cause ____ of the ears

Answer 24

Ringing of the ears.

Question 25

Gentamicin can cause N____ and O______

Answer 25

Nephrotoxicity and Ototoxicity