Chapter 28 - CNS Flashcards

1
Q

Earliest morphological markers of neuronal cell death.

A. Red neurons
B. Subacute injury
C. Axonal reaction
D. Wallerian degeneration

A

A. Red neurons

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2
Q

Most important histopathologic marker of CNS injury

A. Gliosis
B. Astrocytosis
C. Lafora bodies
D. Rosenthal fibers

A

A. Gliosis

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3
Q

Increase in intracellular fluid secondary to neuronal, glial, or endothelial cell membrane injury.

A. Stroke
B. Vasogenic edema
C. Cytotoxic edema
D. Vaso occlusion edema

A

C. Cytotoxic edema

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4
Q

Refers to compensatory increase in ventricular volume secondary to a loss of brain parenchyma.

A. Obstructive hydrocephalus
B. Communicating hydrocephalus
C. Hydrocephalus ex vacuo
D. Subarachnoid hydrocephalus

A

C. Hydrocephalus ex vacuo

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5
Q

Occurs when unilateral or asymmetric expansion of a cerebral hemisphere displaces cingulate gyrus under the falx.

A. Subfalcine herniation
B. Transtentorial herniation
C. Tonsillar herniation
D. Cerebral herniation

A

A. Subfalcine herniation

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6
Q

Refers to an extrusion of malformed brain tissue through a midline defect in the cranium.

A. Anenecephaly
B. Area cerebrovasculosa
C. Myelomeningocele
D. Menigocele
E. Encephalocele
A

E. Encephalocele

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7
Q

Most common neural tube defect

A. Anenecephaly
B. Spina bifida
C. Myelomeningocele
D. Menigocele
E. Encephalocele
A

B. Spina bifida

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8
Q

Malformation characterized by reduction in the number of gyri.

A. Microencephaly
B. Lissencephaly
C. Polymicrogyria
D. Neuronal heterotopias

A

B. Lissencephaly

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9
Q

A clinical syndrome of altered consciousness, secondary to head injury

A. Contusion
B. Concussion
C. Laceration
D. Parenchymal head injury

A

B. Concussion

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10
Q

Depressed, retracted, yellowish brown patches involving crests of gyri

A. Plaque coup
B. Plaque jaune
C. Plaque ulegyria
D. Status marmoratus

A

B. Plaque jaune

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11
Q

Location which is typically associated with underlying parenchymal injury, with sudden onset of severe headache

A. Epidural space
B. Subdural space
C. Subarachnoid space
D. Intraparenchymal space

A

C. Subarachnoid space

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12
Q

Acute infarct of neurons occurs after how many hours of injury?

A. 0 to 6
B. 6 to 12
C. 12 to 18
D. 18 to 24

A

B. 6 to 12

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13
Q

Occurs when there is generalized reduction of cerebral perfusion or decreased oxygen carrying capacity of the blood

A. Focal cerebral hypoxia/ischemia
B. Global cerebral hypoxia/ischemia
C. Lacunar infarcts
D. Evolving infarcts

A

B. Global cerebral hypoxia/ischemia

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14
Q

Which of the following is most commonly associated with deep brain parenchymal hemorrhages?

A. Diabetes mellitus
B. Hypertension
C. Cerebral amyloid angiopathy
D. Optic neuropathy

A

B. Hypertension

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15
Q

Most common type of intracranial aneurysm

A. Saccular aneurysm
B. Subarachnoid aneurysm
C. Subdural aneurysm
D. Cerebral aneurysm

A

A. Saccular aneurysm

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16
Q

Most common site of arteriovenous malformations

A. Anterior cerebral artery
B. Middle cerebral artery
C. Posterior cerebral artery
D. Distal cerebral artery

A

B. Middle cerebral artery

17
Q

Stroke is a clinical term for acute-onset neurologic deficit that last longer for more than how many hours?

A. 24
B. 36
C. 48
D. 72

A

A. 24

18
Q

Most common route of infection

A. Hematogenous
B. Direct implantation
C. Local extension
D. Peripheral extension

A

A. Hematogenous

19
Q

Negri bodies are pathognomonic microscopic finding in which of the ff:

A. Poliomyelitis
B. VZV
C. CMV
D. Rabies

A

D. Rabies

20
Q

Which of the following shows behavioral changes and language disturbance?

A. AD
B. FTLD
C. PD
D. PSP

A

B. FTLD

21
Q

Most common cause of dementia in older adults.

A. AD
B. HD
C. FTLD
D. PD

A

A. AD

22
Q

Pick bodies are seen in which of the following?

A. AD
B. HD
C. FTLD
D. PD

A

C. FTLD

23
Q

A characteristic gross finding in this disease is pallor of substantia nigra

A. AD
B. HD
C. FTLD
D. PD

A

D. PD

24
Q

The brain in this disease shows striking atrophy of caudate nucleus and the putamen

A. AD
B. HD
C. FTLD
D. PD

A

B. HD

25
Q

This disease results from deficiency of galactocerebrosidase B-galactosidase

A. Krabbe disease
B. Metachromatic leukodystrophy
C. Adrenoleukodystrophy
D. Cerebral dysplasia

A

A. Krabbe disease

26
Q

Irreversible condition of vitamin B1 deficiency marked by disturbances of short-term memory and confabulation

A. Wernicke-Korsakoff syndrome
B. Wernicke encephalopathy
C. Korsakoff syndrome
D. Thiamin deficiency

A

C. Korsakoff syndrome

27
Q

Most common embryonal neoplasm

A. Medulloblastoma
B. Retinoblastoma
C. Choroidoblastoma
D. Neuroblastoma

A

A. Medulloblastoma

28
Q

Which of the following vitamin deficiency leads to degeneration of spinal cord

A. B1
B. B6
C. B8
D. B12

A

D. B12