Chapter 19 - Pancreas Flashcards
All of the following are TRUE about serous cystic neoplasm EXCEPT:
A. Occur in the tail of pancreas
B. Women > Men
C. Inactivation of VHL gene
D. None of the options
D. None of the options
All of the following are TRUE about mucinous cystic neoplasm EXCEPT:
A. Women > Men B. Precursor to invasive carcinomas C. Painful, growing masses D. KRAS, TP53 and RNF43 mutations E. None of the options
C. Painful, growing masses = painless
All of the following are TRUE about intraductal papillary mucinous neoplasms (IPMNs) EXCEPT:
A. Men > Women B. Involve tail of the pancreas C. Absence of the dense “ovarian” stroma D. Involvement of a pancreatic duct E. None of the options
B. Involve tail of the pancreas = head
Which of the following is the precursor lesion to invasive pancreatic cancers?
A. Pancreatic intraepithelial neoplasia
B. Pancreatic extraepithelial neoplasia
C. Pancreatic interepithelial neoplasia
D. All of the options
A. Pancreatic intraepithelial neoplasia
Which of the following is the most frequently altered oncogene in pancreatic cancer?
A. KRAS
B. CDKN2A
C. SMAD4
D. TP53
A. KRAS
Pancreatic cancers arise mostly in which of the following?
A. Head
B. Body
C. Tail
D. Entire pancreas
A. Head
All of the following are TRUE about pancreatic neoplasms EXCEPT:
A. Most are ductal adenocarcinomas
B. Benign
C. Elicit desmoplastic response w/ deposition of dense collagen
D. Most are hard, stellate, gray-white, poorly defined masses
E. None of the options
B. Benign = highly malignant
Which of the following is the strongest risk factor for pancreatic cancer?
A. Alcohol
B. Smoking
C. Poor hygiene
D. Fat rich diet
B. Smoking
KRAS and CDKN2A mutations represent which of the following?
A. Normal
B. Low grade
C. High grade
D. Invasive carcinoma
B. Low grade
Which of the following is the defining diagnostic feature of pancreatoblastoma?
A. Squamoid nests
B. Columnar islands w/ acinar cells
C. Pan-acinar cells
D. All of the options
A. Squamoid nests
