Chapter 13 - Disease of the WBCs, etc Flashcards
All of the following are TRUE about Non-Hodgkin Lymphomas EXCEPT:
A. Most often localized
B. Noncontiguous spread
C. Waldeyer ring and mesenteric nodes involved
D. Extranodal presentation common
A. Most often localized
According to the WHO classification of Hodgkin lymphoma, which of the following is the most common subtype?
A. Nodular sclerosis B. Mixed cellularity C. Lymphocyte-rich D. Lymphocyte depletion E. Nodular lymphocyte predominant
A. Nodular sclerosis = stage I or II
MC = stage III or IV; males
Which of the following cells are diagnostic of Hodgkin Lymphoma?
A. Large B-cells
B. Reed-Sternberg cells
C. Tubercle cells
D. Carbuncle cells
B. Reed-Sternberg cells
What stage of Hodgkin and non-Hodgkin lymphoma involves single lymph node region?
A. I
B. II
C. III
D. IV
A. I
II = 2 or more III = both sides of diaphragm IV = diffuse / extralymphatic
At least how much of myeloid blasts must be present to diagnose AML?
A. 10%
B. 20%
C. 30%
D. 40%
B. 20%
What type of leukemia has the presence of BCR-ABL gene?
A. AML
B. ALL
C. CML
D. CLL
C. CML
Philadelphia chromosome is translocation b/w what chromosomes?
A. 11 and 22
B. 9 and 22
C. 5 and 7
D. 9 and 17
B. 9 and 22
Histiocytosis is a proliferative disorder of what type of cells?
A. Monocytes
B. Dendritic cells
C. Lymphocytes
D. Neutrophils
B. Dendritic cells
This is also seen in DiGeorge syndrome which is marked by severe defects in cell-mediated immunity
and variable abnormalities of parathyroid
development
A. Thymic hypoplasia
B. Thymic hyperplasia
C. Isolated thymic cysts
D. Thymoma
A. Thymic hypoplasia
Thymic hyperplasia = encountered in MG; “follicular hyperplasia”
Isolated thymic cysts = postmortem / surgery
Thymoma = tumor
Most of the thymic carcinoma are ________
A. Small cell carcinoma
B. Squamous cell carcinoma
C. Stratified cell carcinoma
D. Cuboidal cell carcinoma
B. Squamous cell carcinoma
Most of the thymomas arise in the ________
A. Anterior superior mediastinum
B. Anterior inferior mediastinum
C. Posterior superior mediastinum
D. Posterior inferior mediastinum
A. Anterior superior mediastinum
What type of thymoma is cytologically benign and
penetrates through the capsule into surrounding
structures?
A. Noninvasive thymoma
B. Invasive thymoma
C. Thymic carcinoma
D. All of the above
B. Invasive thymoma
CML usually presents which of the following blood results?
A. Leukopenia
B. Leukocytosis
C. Neutropenia
D. Thrombocytopenia
B. Leukocytosis
What subtype of Hodgkin Lymphoma is CD 15+ and CD30+?
A. Nodular sclerosis B. Mixed cellularity C. Lymphocyte-rich D. Lymphocyte-depletion E. All of the above
E. All of the above
Presence of Birbeck granules are seen in what disease?
A. AML
B. CML
C. LCH
D. CLL
C. LCH
