Chapter 11 Part VI

Question 1

disseminated intravascular coagulation
immune thrombocytopenia pupura
von Willebrand disease
Hemophilia A
Hemophilia B

Answer 1

5 hallmark conditions of bleeding disorders

Question 2

bleeding disorder with widespread thrombi: clots that depletes platelets/clotting factors –> hemorrhage; causes are SYSTEMIC coagulation (sepsis, SLE, heat stroke, SEVERE INJURY)

Answer 2

disseminated intravascular coagulation (DIC)

Question 3

disseminated intravascular coagulation usually presents with clots in _____, _____ or _____ and many times is a lethal condition

Answer 3

kidneys
adrenals
brain

Question 4

bleeding disorder with decrease platelets (decrease production or increase destruction)
small PETECHIAE –> large ECCHYMOSES (looks like large bruises)

Answer 4

thrombocytopenia

Question 5

there are normally 150,000 cells/uL but with thrombocytopenia there can be ________ cells with post-traumatic bleeding or _______ cells with spontaneous bleeding

Answer 5

20,000-50,000 cells

Question 6

red/purple discoloration of skin

Answer 6

purpura

Question 7

bleeding disorder in which antibodies attack platelet membranes that are removed in spleen and produces a bleeding tendency

Answer 7

immune thrombocytopenic purpura

Question 8

category of immune thrombocytopenia purpura that MC affects KIDS, self-limited, secondary to viral INFXN

Answer 8

acute ITP

Question 9

category of immune thrombocytopenia purpura that is MORE COMMON; insidious, ADRs, lymphomas, idiopathic

Answer 9

chronic ITP

Question 10

chronic ITP is _______ and affects ______ ages _____

Answer 10

more common
females
20-40 y.o.

Question 11

treatment for ITP is _____ and usually is ____ % remission

Answer 11

splenectomy

65%

Question 12

bleeding disorder that is autosomal DOMINANT and is MC INHERITED

Answer 12

von Willebrand disease

Question 13

von WIllebrand disease mimics _______ and has dysfunctional platelet _______ to vessel wall; bleeding gums, easy bruising

Answer 13

thrombocytopenia

adherence

Question 14

Hemophilia A and B affect ______ and is ___-linked

Answer 14

males

x-linked

Question 15

Hemophilia A is usually ___% sporadic mutations with _______

Answer 15

30%

factor VIII

Question 16

____ is AKA Christmas disease

Answer 16

hemophilia B

Question 17

bleeding disorder that clinically identical to Hemophilia A, but LESS COMMON

Answer 17

hemophilia B

Question 18

treatment for hemophilia B is infusion of ______

Answer 18

factor IX

Question 19

Myasthenia gravis patients, SLE, RA, reactive B cells within the thymus

Answer 19

thymic hyperplasia

Question 20

rare carcinoma that can be benign or malignant and MC affects ADULTS or myasthenia gravis patients – cough, dyspnea, SVCs

Answer 20

thymoma