Chapter 11 Part II (QUIZ) Flashcards
Sickle cell anemia is autosomal ______ with an mutation/instability of the _____ globin
recessive
B-globin
8% of African Americans are ______ or _____
heterozygous carriers
sickling –> _______ obstruction
microvascular obstruction
locations of sickle cell anemia occurs in areas of _____; bone marrow, spleen; usually has symptoms of _____ and _____/inflammation
stasis
dehydration
infection
thrombosis, chronic low-level pain, joint pain, priapism, fever, malaise, splenomegaly/infarction, gallstones are symptoms of
sickle cell anemia
heterozygous carriers for sickle cell anemia are RARELY _____ ; homozygous: ___% survive beyond 5th decade
symptomatic
50%
MC cause of death in someone with SCA (2)
acute chest syndrome
stroke
MC location of congestion/infarction for SCA
bone marrow
vertebral involvement in SCA is called _______; microvascular endplate infarctions with central endplate depression
Lincoln log vertebra (H-shaped vertebra)
thalassemia is autosomal ________ with abnormal ______ PRODUCTION
recessive
hemoglobin
hemoglobin shape in thalassemia (2)
microcytic (small)
hypochromic (pale)
areas of endemic malaria (2)
africa
SE asia
B-thalassemia is on chromosome ____
11
A-thalassemia is on chromosome ___
16
mutation in thalassemia is excess of the ________ globin chain
opposite
in thalassemia, there is damage to _____ called HEMOLYSIS and damage to ____
RBCs
erythroblasts
in ______ thalassemia, there is decreased B-globin chain synthesis and excess of unpaired A chains
B-thalassemia
aka B-thalassemia trait; features are ASYMPTOMATIC or MILD; normal life span of RBC; treatment is often not necessary
B-thalassemia minor
type of B-thalassemia that has severe hemolysis/anemia with SKELETAL DEFORMITIES; leads to eventual IRON OVERLOAD
b-thalassemia major