Ch. 36 GI - Book/2 Flashcards
UC is less common in people who
smoke
CD and smoking
increases the risk for developing severe disease
sx of DD
5
- cramping of lower abdomen
- diarrhea
- constipation
- distention
- flatulence
risk factors and theories of cause of IBDs include
4
- genes
- environment
- alterations in epithelial cell barrier function
- altered immune response to intestinal microflora
most common areas for CD
2
- distal small intestine
2. proximal large colon
diverticular disease is associated with 3 -increased -abnormal -alterations
- increased intracolonic pressure
- abnormal neuromuscular function
- alterations in intestinal motility
what meds are used for tx of serious UC
3
- thioprine agents
- immunodulatory agents
- vedolizumad
idiopathic inflammatory disorder that affects any part of the GI tract from mouth to anus
CD
rectum aka
proctitis
diverticula
herniations or saclike outpouchings of the mucosa and submucosa through the muscle layers in the sigmoid colon
uncomplicated DD is tx with
2
- bowel rest
2. analgesia
imaging of the small intestine is used in dx what
CD
complicated diverticulitis includes
5
- abscess
- fistula
- obstruction
- bleeding
- perforation
what often relieves symptoms of DD
2
- increase fiber
2. probiotics
DD common associated finding is
thickening of the circular muscles and shortening of the longitudinal muscles surrounding the diverticula
what may cause large amounts of watery diarrhea in UC
2
- loss of absorptive mucosal surface
2. rapid colonic transit time
effective for initial therapy for CD
immunomodulatory (anti-TNF)
UC mucosal destruction and inflammation causes
3
- bleeding
- cramping pain
- urge to defecate
most common sx of CD
diarrhea
chronic inflammatory disease that causes ulceration of the colonic mucosa
UC
asymptomatic diverticular disease
diverticulosis
diverticulosis is
asymptomatic diverticular disease
UC that involve the entire colon sx
7
- abdominal pain
- fever
- elevated pulse rate
- frequent diarrhea
- urgency
- bloody stool
- crampy pain
what type of stool is common in UC
frequent diarrhea with passage of small amounts of blood and purulent mucus
CD aka
3
- granulomatous colitis
- ileocolitis
- regional enteritis
diverticula most common location
sigmoid colon
bleeding and cramping pain from anus
UC
UC complications include
3
- fissures
- hemorrhoids
- perirectal abscess
chronic relapsing IBDs
2
UC
CD
component of therapy for CD
stop smoking
predisposing factors for DD
7
- older age
- genes
- obesity
- smoking
- diet
- lack of physical activity
- medications (aspirins)
if the diverticula become inflamed or abscesses form, what can develop
3
- fever
- leukocytosis
- tenderness of the LLQ
CD typical lesion is a
granuloma with a cobblestone appearance
most common site for skip lesions of CD
2
- ascending colon
2. transverse colon
urge to defecate is to
UC
sx of CD
4
- diarrhea
- rectal bleeding
- weight loss
- abdominal pain
UC
chronic inflammatory disease that causes ulceration of the colonic mucosa
diverticula can occur where
anywhere in GI tract, particularly in weak points in the colon wall
CD inflammation begins and spread with
begins in the intestinal submucosa and spreads with discontinuous transmural involvement (skip lesions)
if CD involved the ileum what may the patient be
anemic as a result of malabsorption of vitamin B12
frequent diarrhea with small amounts of blood and purulent mucus
UC
UC common location
2
rectum
sigmoid colon
UC mucosa is
hyperemic and may appear dark red and velvety
UC mild to mod disease is tx with
2
5-aminosalicyclate therapy followed by steroids
definitive tx for CD
none
hypoalbuminemia is a sx of
CD
the primary lesion of UC begins with
inflammation at the base of the crypt of Lieberkuhn in the large intestine
biomarkers for CD
none
CD
idiopathic inflammatory disorder that affects any part of the GI tract from mouth to anus
herniations or saclike outpouchings of the mucosa and submucosa through the muscle layers in the sigmoid colon
diverticula
UC lesions appear around what age
20-40 yrs old
the course of UC consists of
intermittent periods of remission and exacerbation
what medications can cause DD
2
- aspirin
2. non-steroidal anti inflammatory drugs
CD - fistulae may form in the
perianal area
ulcerations of CD can produce
fissures that extend inflammation into lymph tissue
diverticulitis
represents inflammation
cause of diverticular disease is
unknown
disease begins in the rectum and extends proximally to the entire colon
UC
