ch 21: drugs for neuromuscular disorders and muscle spasms Flashcards
what do steroids end in?
(-sone) or (-lone)
what is myasthenia gravis? what neurotransmitter is at a loss? what is enlarged?
- autoimmune disease
- decrease in ACh
- enlarged thymus gland
what are the two drug classes used for myasthenia gravis?
- ACh inhibitors
- things only used when ACh inhibitors don’t work
what are ACh inhibitors for myasthenia gravis? what are the side effects?
- preventing the destruction of ACh
- SLUDGE and bradycardia
what does rebound mean?
worse side effects than the started with
what can patients with myathenia gravis get when ACh inhibitors do not work anymore?
- prednisone
- plasma exchange
- immunosuppressive drugs
what is myasthenia crisis? cholinergic crisis?
- underdosed
- overdosed
what is multiple sclerosis? what is it characterized by?
- autoimmune disease
- attacks in myelin sheath of the nerve fibers in the brain and spinal cord
- weakness, spascity in extremities, and diplopid
what are the drug classes used ofr MS?
- immunomodulators
- spninogosine
- monoclonal antibody
- immunosuppressant
- corticosteroids
- muscle relaxants
what are immunomodulators used as for MS?
-1st line of treatment
what do spininogosine do for MS?
decrease in lymphocytes in blood and crossing BBB which means no neuro injury
what do monoclonal antibody end in? what can these cause in MS?
- (-mab)
- can cause a reactivation in a virus which can lead to PML=death
what do corticosteriods end in? what do they do for MS?
- (-olone) and (-sone)
- reduces edema and inflammation
what is the muscle relaxant drug we need to remember? what are the side effects?
- cyclobenzaprine
- ANTISLUDGE and tachycardia
