Ch 14: Digestive System Flashcards
What is the GI tract flow?
Mouth
Esophagus
Stomach
Small Intestine (Duodenum > Jejunum > Ileum)
Large Intestine [Colon] (Cecum > Transverse colon > Descending colon > Sigmoid colon)
Rectum
Anus
What is the GI tract?
Long tube that’s open at both ends for the transit of food during processing
What are accessories?
Salivary glands
Liver
Gallbladder
Pancreas
What are the 4 digestive system functions?
Ingestion
Digestion
Absorption
Defecation
What is ingestion?
Taking in food
What is digestion?
Breaking food into nutrient molecules
What is absorption?
Movement of nutrients into the blood stream
What is defacation?
Excrete to rid the body of indigestible waste
What are the 4 layers of the GI tract from inner most to outer most?
Mucosa
Submucosa
Muscularis externa
Serosa
What is the peritoneum?
Serous membranes of abdominal cavity
What are the 3 peritonea?
Visceral peritoneum
Parietal peritoneum
Peritoneal cavity
Which peritoneum is this:
External surface of most digestive organs
Visceral peritoneum
Which peritoneum is this:
Lines body wall
Parietal peritoneum
What is the peritoneal cavity?
Fluid filled space between the 2 peritonea
What is the name of the double layer of peritoneum?
Mesentery
What does the mesentery do?
- Extends from body wall to digestive organs
- Routes for blood vessels, lymphatics, and nerves
- Holds organs in place
- Stores fat
What is this:
- Collapsible, muscular tube
- Posterior to the trachea
- Passes through diaphragm to join stomach
- Gastroesophageal sphincter
Esophagus
What does the Gastroesophageal sphincter do?
Prevents regurgitation of food from stomach
How many layers of smooth muscle does the stomach have?
3
Longitudinal, Circular, Oblique
What does the rugae do?
Expands to accommodate for food
What are these the functions of?
- Mixes saliva, food, and gastric juice to form chyme
- Secretes gastric juice: HCl, Pepsin, Intrinsic factor, Gastric lipase
- Reservoir for food before release into small intestine
- Secretes gastrin into the blood
Stomach
What is intrinsic factor required for?
Absorption of vitamin B12
What is the main hormone that regulates acid secretion in stomach?
Gastrin
What is the 1st layer of the stomach barrier?
Thick layer of bicarbonate - rich mucus
What is the 2nd layer of the stomach barrier?
Tight junctions between epithelial cells
(prevent juice seeping underneath tissue)
What is the 3rd layer of the stomach barrier?
Damaged epithelial cells are quickly replaced by division of stem cells
(surface cells are replaced every 3-6 days)
What is gastrin activated by?
Vagus nerve
Gastrin related peptide
Peptides in stomach lumen
How is gastrin produced?
Released into blood until it reaches parietal cells
The small intestine is from what to what?
Pyloric sphincter to ileocecal valve
What are the functions of the small intestine?
- Receive chyme
- Absorb products of digestion
- Transport residues to large intestine
What are the 3 types of villi
Brush border
Goblet cells
Intestinal glands
What do goblet cells secrete?
Mucous
What are the 2 plexus of the Enteric Nervous System?
Submucosal plexus
Myenteric plexus
What’s another name for the Submucosal plexus?
Plexus of Meissner
What does the Submucosal plexus (of meissner) control?
Local secretion, absorption and muscle movements
What’s another name for the Myenteric plexus?
Plexus of Auerbach
What does the Myenteric plexus (of auerbach) do?
Increases tone of the gut and velocity and intensity of contractions
What are the 2 neural innervations of the gut - ANS?
Parasympathetic and Sympathetic
What is the increase of GI secretion / motility by increasing activity of ENS neurons?
Parasympathetic
What is the decrease in GI secretion / motility by inhibiting ENS neurons?
Sympathetic
What are the 4 regulating digestive activities?
1 Stimuli
2 Effectors
3 Neurons
4 Hormonal Controls
Which Regulating Digestive Activity is this:
- Receptors in walls of GI tract
- Stretch, osmolarity, pH, presence of substrate and end products of digestion
Stimuli
Which Regulating Digestive Activity is this:
- Smooth muscle and glands
- Stimulate smooth muscle to mix and move lumen contents
- Activate or inhibit digestive glands that secrete digestive juices or hormones
Effectors
Which Regulating Digestive Activity is this:
- Intrinsic controls: short reflexes (ENS)
- Extrinsic controls: long reflexes (ANS)
- Nervous system control
Neurons
Which regulating digestive activity is this:
- Hormones from cells in stomach and small intestine
- Stimulates target cells in same or different organs to secrete or contract
Hormonal Controls
What is segmentation?
Localized contractions
Nonadjacent segments of the alimentary canal organs contract and relax
What is peristalsis?
Propulsive contractions
Adjacent segments of the alimentary canal organs alternatively contract and relax
Secretion is stimulated by what?
Gastric juice
Chyme
and / or
Distention of small intestine wall
Capillaries in the villi absorb what?
- Water
- Monosaccharides
- Electrolytes
- Amino acids
- Short chain fatty acids
What does the absorptive cell absorb?
Water
What is this:
- Rectal wall distends
- Stretch receptors send sensory nerve impulses to sacral spinal cord
- Motor impulses to descending colon, sigmoid colon, rectum, and anus
- Longitudinal rectal muscles contract internal anal sphincter opens
Defecation Reflex
How many liters is Saliva?
1 liter
How many liters is Ingestion of liquids?
2.3 liters
How many liters is gastric juice?
2 Liters
How many liters is bile?
1 liter
How many liters is pancreatic juice?
2 liters
How many liters is intestinal juice?
1 liter
What’s the total fluid balance of ingested and secreted?
9.3 Liters
How many liters of fluid balance is the small intestine?
8.3 liters
How many liters of fluid balance is the large intestine?
0.9 liters
What’s the total of absorbed fluid balance?
9.2 liters
How many liters of fluid balance is ecreted in feces?
0.1 Liters
What does the pancreas produce?
Enzymes that digest carbohydrates, proteins, fats, and nucleic acids
Sodium bicarbonate which buffers stomach acid
Pancreas empties its contents into what?
The duodenum
What does the pancreatic amylase break down?
Carbohydrates into disaccharides
What does the pancreatic lipase break down?
Triglycerides into glycerol and fatty acids
What does the trypsin, chymotrypsin, and carboxypeptidase (proteolytic enzymes) break down?
Proteins into peptides
What does the nuclease break down?
Nucleic acids into nucleotides
What does NaHCO3 neutralize?
Acidic chyme
What is this:
- Metabolizes carbohydrates, lipids, and proteins
- Stores glycogen
- Filters blood
- Removes toxins
- Secretes bile
Liver
What is the portal circulation?
Artery -> Capillary -> Vein -> Capillary -> Vein
What is bile?
Emulsification of fats
What does gallbladder do?
Stores bile until needed
What does the Duodenal Hormone CCK do?
Triggers bile release