cell pathology Flashcards
study of tissue diseases
histopathology
essential part of most living cells w/ DNA, RNA, proteins
nucleus
in resting cells, components in nucleus aggregate as ____ and in dividing cells, condense into ___
chromatin; chromosomes
all human cells except ___ need nucleus
platelets and RBC
^ N:C ratio found in:
tumour cells, embryonic cells (undifferentiated)
cytoplasmic ground substance
hyaloplasm
primary site of protein synth
RER
catabolism of drugs/hormones/nutrients and synth of steroids
SER
_____- are formed in golgi
glyco/lipoproteins
primary lysosomes have acid ____
hydrolases
secondary lysosomes (fusion with foreign vesicles) called
heterophagosomes
plasma mem arranged in ____ bilayer
polarized complex
paracrine stim by:
biogenic amines and neuropeptide hormones
endocrine stim by:
hormones released into blood
inside enviro of cell
internal milieu
ex. of oligominerals
zinc, copper, selenium, magnesium
what are essential minerals?
iron, chloride, potassium, calcium
reversible cell injury characterized by:
swollen mito,, switch to anaerobic metabolism, degranulated RER
reversible cell injury may be produced by:
expose to toxins, hypoxia
irreversible cell injury characterized by:
nuclear changes–>ultrastructural
3 types nuclear damage
pyknosis (dense chromatin), karyorrhexis (fragmentation), karyolysis (dissolution)
causes of cell injury
hypoxia, toxins, microbe pathogens, endogenous mediators, gene/metabolic disturbances
examples of hypoxia
myocardial infarction, choking
Cells change to another type
Metaplasia
Usually due to chronic irritation or hormone stim
Hyperplasia
3 types of necrosis
Coagulative, liquifactive, caseous
Type of necrosis in TB
Caseous (cheesy)
Secondary Infection of necrotic tissue
Gangrène
decrease in size of cell
atrophy
hyperplasia caused by :
hormonal stim, chronic irritation
accumulation of coal particles
anthracosis
accumulation of blood-derived brown pigment
hemosiderosis
exogenously induced death
necrosis
programmed cell death
apoptosis
death of cells after death of organism
autolysis
most common type of necrosis marked by rapid inactivation of hydrolytic enzymes?
coagulative
liquefactive necrosis common in_____
brain