Cell Communication And Signalling Flashcards
What are stable cell-cell interactions required for?
Cell adhesion within a tissue
Anchoring cell in the Extra Cellular Matrix (ECM)
What are the three types of junctions?
Gap junctions
Anchoring junctions
Tight junctions
What is a gap junctions?
2 cylindrical channels that are joined to form a pore
What are the 4 main transient cell communication ways?
Contact dependant
Paracrine
Synaptic
Endocrine
What are contact dependant cell communication?
Binds to a receptor
Between immune cells
Via gap junctions
What are paracrine cell communication?
Extracellular fluid
Acts locally
What are synaptic cell communication?
Axon
Release neurotransmitters
What are endocrine cell communication?
Release signals called hormone
Run through bloodstream
What is autocrine signalling?
Signals that act back on the secreting cell
What are the steps of cell signalling pathway?
- Signal receptor binding
- Signal transduction
- Specific cell response
What types of receptors are used in receptor binding?
Ion channel coupled receptors
G-protein coupled receptor
Enzyme coupled receptors
What are the different pathways for the transduction step?
Protein phosphorylation cascade
Small molecules and ions as second messenger
What does cellular response lead to?
Regulation of one or more cellular activities
