Cartilage Pre-Assigned Readings

Question 1

Chondroblasts arise from and location

Answer 1

-Chondrogenic cells give rise to chondroblasts

-location: just below chondrogenic layer
of perichondrium (P)

Question 2

lacuna

Answer 2

The space occupied by a chondroblas

Question 3

Responsible for external growth of cartilage

Appositional growth

Answer 3

Chondroblasts

Question 4

Chondrocytes

Answer 4

-Are matured chondroblasts
located in the lacunae and
surrounded by matrix
• Located deeper to the
chondroblasts and are more
spherical

Question 5

Isogenous groups or cell nest

Answer 5

Chondrocytes Divide by mitosis to form groups

of 4-8 chondrocytes

Question 6

Chondroclast

Answer 6

originate from monocytes • help to remodel the cartilage

Question 7

internal growth of cartilage.

Answer 7

As chondrocytes in isogenous
groups mature, they move apart
by their own synthesis of ECM.

Question 8

Extra Cellular Matrix (ECM)

Answer 8

Constitutes >95% of cartilage volume
•Composed of amorphous ground
substance and collagen fibrils
•Collagen constitutes about 15% of the total
mass with Type II being most abundant.

Question 9

Capsular matrix

Answer 9

• matrix
  adjacent to the chondrocyte - also called paracellular matrix
  Highest concentration of sulfated proteoglycans,
  hyaluronan, biglycans, and several multiadhesive
  glycoproteins.
  • Less collagen fibers
  • Basophilic staining with H/E

Question 10

Territorial matrix (TM)

Answer 10

matrix found around
isogenous groups
Randomly arranged network of type II collagen fibrils
with smaller quantities of type IX collagen.
• Lower concentration of sulfated proteoglycans
• Less basophilic than the capsular matrix

Question 11

. Interterritorial matrix (IM)

Answer 11

-matrix in-between isogenous
groups
Composition is a mixture between territorial matrix and
capsular matrix.

Question 12

Perichondrium (P)

Answer 12

Connective tissue covering entire cartilage
(except articular
and epiphyseal hyaline cartilage, and
fibrocartilage)

Question 13

Perichondrium (P)-Outer fibrous layer contains

fibroblasts

Answer 13

synthesize collagen

type I and matrix

Question 14

Perichondrium -Inner cellular layer

Answer 14

chondrogenic cells

Source of chondroblasts

Question 15

Cartilage is avascular -Nutrients are supplied by?

Answer 15

vessels from perichondrium
by diffusion, Or from the
synovial fluid at the articular
surfaces.