C / 7 - agents against hepatitis viruses Flashcards
1
Q
Type of virus : HAV, HBV, HCV, HDV
A
- HAV : RNA
- HBV : DNA
- HCV : RNA
- HDV : RNA
2
Q
Which viruses are the most common causes of chronic hepatitis and cirrhosis?
A
Hepatitis B and C (only ones which currently have ttmt)
3
Q
Treatment options for HBV (3)
A
- Nucleoside / nucleotide derivative (tenofovir, entecavir)
- IFN alpha derivative
- Vaccination
4
Q
Treatment options for HCV (2)
A
- Combination therapy based on genotype
- Triple therapy : IFN alpha derivative + ribavirin + telaprevir
5
Q
Interferon alpha
MOA
Spectrum
ROA
Toxicity
A
- Complex antiviral activity (induces production of antiviral proteins)
- Hepatitis B (chronic), Hepatitis C (acute and chronic)
- Subcutaneous injection
- Flu-like symptoms, GI symptoms, suppression of hematopoiesis
6
Q
Tenofovir
MOA
Spectrum
ROA
Toxicity
A
- Nucleotide analog + antiretroviral agent
- HBV
- Oral
- Nephrotoxicity, GI symptoms
7
Q
Entecavir
MOA
Spectrum
ROA
Toxicity
A
- Guanosine analog, inhibits DNA polymerase
- HBV
- Oral
- Headache dizziness, fatigue, nausea
8
Q
Ribavirin
MOA
Spectrum
ROA
Toxicity
A
- Guanosine analog, inhibits viral RNA polymerase
- HCV (+ HSV, influenza)
- Oral, aerosol
- Hemolytic anemia, teratogenic, irritation
9
Q
Sofosbuvir
MOA
Spectrum
Toxicity
A
- Nucleotide analog, inhibits RNA dependant RNA polymerase
- HCV
- No toxicity
10
Q
Dasabuvir
MOA
Spectrum
Indication
A
- Non nucleoside polymerase inhibitor
- HCV
- Used with paritaprevir for type 1 HC
11
Q
Paritaprevir, grazoprevir
MOA
Spectrum
ROA
Toxicity
A
- Protease inhibitor : NS3
- HCV
- Oral
- Skin reaction, photosensitivity
12
Q
Velpatasvir
MOA
Spectrum
Indication
A
- Protease inhibitor : NS5a
- All genotypes of HCV
- Used in combination with sofosbuvir
13
Q
What is the most effective combination for the treatment of HCV?
A
Sofosbuvir + Velpatasvir
