C / 12 - tetracyclines and glycylcyclines

Question 1

MOA of tetracyclines and glycylcyclines (2)

Answer 1

• Bind to 30s subunit and inhibits binding of tRNA : bacteriostatic
• Tetracyclines also act as chelators

Question 2

Doxycycline (tetracycline)
Spectrum (3)
Indications (4)
Pharmacodynamics
Toxicity (4)
Contraindications
ROA
Dose

Answer 2

• Rickettsia, H pylori, sprichetes
• Community acquired pneumonia, gonorrhea, chlamydia, lyme disease
• High liposolubility : accumulates intracellularly
• GI disturbances, dental staining, hepatotoxicity, nephrotoxicity
• Children under 10 and pregnancy
• Oral
• 200mg the first day, then 100mg/day

Question 3

Tigecycline (glycylcycline)
Spectrum
Indications
Resistant bacterias
ROA
Toxicity

Answer 3

• Broader spectrum than tetracycline : MRSA + VRSA as well
• Skin and intrabdominal infections
• Pseudomonas and proteus
• IV
• Same as tetracycline