C / 16 - clindamycin, streptogramins, oxazolidinones, fusidans

Question 1

Clindamycin
MOA
Spectrum
Indications
ROA
Toxicity (3)

Answer 1

• Binds to 50S subunit
• Gram (+) cocci and anaerobic organisms
• Staphylococcus infections
• Oral, parenteral
• GI symptoms, skin rash, hepatotoxicity

Question 2

Example of streptogramins

Answer 2

quinupristin / dalfopristin

Question 3

Quinupristin / dalfopristin
MOA
Spectrum
Indications
ROA
Toxicity

Answer 3

• Binds to 50S subunit, bactericidal when used together
• Gram (+) cocci, MRSA, VRSA
• Reserve antibiotics for resistant infections
• IV
• Arthralgia-myalgia syndrome

Question 4

Example of oxazolidinones

Answer 4

Linezolid

Question 5

Linezolid
MOA
Spectrum
Indications
ROA
Toxicity (4)

Answer 5

• Binds to 50S subunit
• Gram (+) resistant organisms (MRSA, VRE…)
• For vancomycin resistant bacteria (E. faecium + staphylococcus)
• Oral, parenteral
• Thrombocytopenia, anemia, neutropenia, serotonin syndrome (if used with SSRIS)

Question 6

Fusidic acid
MOA
Spectrum
Indications
ROA
Toxicity

Answer 6

• Binds to 50S subunit (protein synthesis inhibitor)
• Gram (+) : staphylococci
• Serious staph infections, MRSA endocarditis
• Oral, parenteral, topical
• Hepatotoxicity