C / 4 - antifungal agents

Question 1

What are the azoles?

Answer 1

• Fluconazole
• Itraconazole
• Clotrimazole
• Voriconazole

“c vif”

Question 2

What are the polyenes?

Answer 2

• Nystatin
• Amphotericin B

Question 3

Antifungal azoles
- MOA
- ROA
- Pharmacodynamics
- Side effects

Answer 3

• Ergosterol synthesis inhibitors (change the membrane structure)
• Oral, parenteral, topical
• Only fluconazole can cross the BBB
• GI symptoms, skin rash, neuropathy, headaches

Question 4

Spectrum of…
- Fluconazole
- Itraconazole

Answer 4

• Candidiasis
• Aspergillus, coccidoides, cryptococcus, histoplasma

Question 5

Nystatin, amphotericin B
- MOA
- Spectrum
- ROA
- Pharmacodynamics
- Toxicity

Answer 5

• Forms pores in the fungal membrane by binding to sterols
• AB : broad spectrum / Nystatin : mouth and oesophageal candidiasis
• AB : parenteral / Nystatin : topical
• Poor CNS penetration
• Fever, chills, muscle spasms, CNS toxicity, anemia

Question 6

Caspofungin
- MOA
- Spectrum
- ROA
- Toxicity

Answer 6

• Inhibits polysaccharide synthesis
• Aspergillus, Mucor and Candida infections
• IV
• GI symptoms, fever, headache

Question 7

Terbinafine
- MOA
- Spectrum
- ROA
- Toxicity

Answer 7

• Ergosterol synthesis inhibitor II
• Locally : dermatomycoses / systemically : dermatomycosis + candidiasis
• Topical or oral
• Gi symptoms, headache, rash

Question 8

What category is caspofungin?

Answer 8

Echinocandin