Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

5. Pharmacology AC > C / 5 - herpes, varicella, cytomegalovirus, influenza, corona > Flashcards

C / 5 - herpes, varicella, cytomegalovirus, influenza, corona Flashcards

1
Q

When do antiviral drugs act best?

A

During the acute phase of viral infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Agents used against HSV 1-2 and VZV?

A

Acyclovir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Acyclovir
- MOA
- Spectrum
- ROA
- Toxicity

A
  • Guanosine analog : inhibits viral DNA polymerase
  • HSV1, HSV2, VSZ, it can also be used in IV formulation for HSV encephalitis
  • IV, oral, topical
  • Well tolerated : GI symptoms, headache
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which virus is CMV?

A

it is herpes virus 5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Agents which can be used against CMV?

A
  • Ganciclovir
  • Foscarnet
  • Letermovir

(Let’s fucking go)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Ganciclovir
- MOA
- Spectrum
- ROA
- Toxicity

A
  • Deoxy-guanosine analog : inhibits viral DNA polymerase
  • CMV
  • IV
  • Neutropenia, teratogenic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Foscarnet
- MOA
- Spectrum
- Indication
- ROA
- Toxicity

A
  • Pyrophosphate analog, inhibits viral RNA and DNA polymerase
  • CMV
  • CMV retinitis in HIV/AIDS patients
  • IV
  • Nephrotoxicity, bone alterations, decreased Hb

(FOScarnet : pyroPHOSphate)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Letermovir
- MOA
- Spectrum
- Indication
- ROA
- Toxicity

A
  • Inhibits terminase complex (cleavage of DNA after replication)
  • CMV
  • Prophylaxis for bone marrow transplant
  • Oral, IV
  • Headache, malaise (well tolerated)

(leTERMovir : TERMinase complex)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Agents used against RSV

A
  • Palivizumab
  • Ribavirin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Palivizumab
- MOA
- Spectrum
- Indication
- ROA

A
  • Monoclonal AB against RSV
  • RSV
  • Prophylaxis in immunocompromised children in RSV season
  • Intramuscular monthly
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Ribavirin
- MOA
- Spectrum
- Indication
- ROA
- Toxicity

A
  • Guanosine analog, inhibits viral RNA polymerase
  • Broad spectrum (HSV, VSZ, influenza, RSV)
  • Immunocompromised children with severe RSV
  • Oral, aerosol
  • Drug induced hemolytic anemia, teratogenic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Anti-influenza agents

A

Oseltamivir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Oseltamivir
- MOA
- Spectrum
- ROA
- Toxicity

A
  • Inhibits neuraminidase, so virus cannot infect new cells
  • Influenza A + B
  • Oral
  • GI symptoms
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Drugs used against corona

A
  • Remdesivir
  • Molnupiravir
  • Nirmatrelvir
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Remdesivir
- MOA
- Spectrum
- Indication
- ROA

A
  • RNA dependant RNA polymerase inhibitor
  • Ebola, hepatitis C, corona
  • For medium severity patients, with no cytokine storm
  • IV
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Molnupiravir
- MOA
- Indication
- ROA

A
  • RNA dependant RNA polymerase inhibitor
  • For low - medium severity patients
  • Oral
17
Q

Nirmatrelvir
- MOA
- Indication
- ROA

A
  • Protease inhibitor
  • Corona : For adults with high risk of progression
  • Oral

5. Pharmacology AC (17 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions