C / 18 - metronidazole, fidaxomycine, rifaximin, nitrofurantoin, phosphomycine

Question 1

Metronidazole
MOA
Spectrum
Indications
ROA
Toxicity

Answer 1

• Interferes with nucleic acid synthesis
• Anaerobic gram (-) bacteria + protozoans (eg trichomonas)
• For intra-abdominal infections + brain abscesses
• Oral, parenteral
• GI symptoms, CNS effects, alcohol intolerance

Question 2

Fidaxomicin
MOA
Spectrum
ROA

Answer 2

• Inhibits bacterial RNA polymerase
• Gram (+) anaerobes ( C. difficile)
• Oral

Question 3

Rifaximin
MOA
Spectrum
Indications
ROA

Answer 3

• Inhibits DNA dependant RNA polymerase
• Gram (+) and (-)
• Hepatic encephalopathy
• Oral

Question 4

Nitrofurantoin
MOA
Spectrum
Indications
ROA
Toxicity

Answer 4

• Urinary antiseptic
• Urinary tract pathogens like E. coli
• Uncomplicated lower UTI
• Oral
• GI symptoms, skin rash, pulmonary reactions

Question 5

Phosphomycin
MOA
Spectrum
ROA
Toxicity

Answer 5

• Cell wall synthesis inhibitor
• Gram (+) and (-) bacteria
• Oral, parenteral
• GI symptoms