C / 10 - carbapenems, monobactams, beta-lactamase inhibitors

Question 1

What are the carbapenems?

Answer 1

• Ertapenem
• Imipenem
• Meropenem

Question 2

Carpabenem
- MOA
- Spectrum
- Agents against it
- Toxicity

Answer 2

• Inhibit cell wall synthesis
• Gram (+), Gram (-), anaerobes, aerobes, pseudomonas, resistant to most beta-lactams
• Carbapenemase (MBL) expressed by klebsiella
• Hypersensitivity reaction, GI symptoms, skin rash

Question 3

What is an example of a monobactam?

Answer 3

Aztreonam

Question 4

Beta lactamase inhibitors
Names
MOA

Answer 4

• Clavulanate, tazobactam, vaborbactam
• Used with beta lactams (penicillins, carbapenems…) to prevent splitting of the beta lactam ring to ensure good activity

Question 5

Beta lactamase inhibitor combinations

Answer 5

• Amoxicillin and clavulanate
• Piperacillin and tazobactam
• Meropenem and vaborbactam