Blood Formation Flashcards
What is the System that regulates the amount of RBC’s & Platelets in the blood?
This is regulated by a Negative feedback loop.
RBC’s in the blood normally stay at a regulated level. What in the blood changes in level in response to invaders of the body?
WBC’s respond to Antigens in the body.
What is the process called in which the body develops formed elements?
This process is called “Hemopoiesis”.
In the late stages of fetal development and for the rest of life what becomes the primary site for “Hemopoiesis”?
In the later stages of fetal development and into the rest of life the main site for Hemopoiesis is the “Liver”.
What can yellow bone marrow do in the bones if a person has major bleeding?
It can revert to red bone marrow and start to form blood cells for the body.
What do stem cells in the Red bone marrow do for the blood?
They reproduce themselves & differentiate into cells that give rise to: Blood cells Macrophages Reticular cells Mast cells Adipocytes
What are RBC’s / Erythrocytes?
These cells contain the oxogen carrying protein Called Hemoglobin.
How much RBC’s does a Healthy Adult Male have per microliter of blood?
They have on average 5.4 million RBC’s.
How much RBC’s does a Healthy Adult Female have per microliter of blood?
They have on average 4.8 million RBC’s.
What is the RBC Anatomy?
They are a Biconcave Disc.
Mature RBC’s have a simple structure, Their plasma membrane is both strong and flexible which allows them to deform without breaking when fitting through small capillaries.
What is the RBC Physiology?
Each RBC cell contains about 280 million Hemoglobin molecules.
Each Hemoglobin molecule consist of a protein called Globin composed of four polypeptide chains.
A nonprotein pigment called Heme is bound to each of the four chains.
Why are RBC’s really good for oxygen transport?
This is because they have no nucleus and that space can be used for holding onto oxygen.
The Biconcave surface increases surface area.
The oxygen its carrying doesn’t get used by the cell because of the passive transport.
Why does a RBC not use up the oxygen it is trying to transport?
This is because the cell doesn’t have a Mitochondria and creates ATP without oxygen it can save the payload for the body cells that need the oxygen.
What are all the ways an RBC is good for the transport of oxygen?
This includes:
The shape increases the amount of oxygen it can carry at a time.
They have no nucleus so the internal space of the cell is used for the oxygen.
There is no mitochondria to use the payload.
Besides Oxygen what else does Hemoglobin carry for the RBC’s?
They also transport about 23% of the carbon dioxide.
