Blood Chem: Liver Disease

Question 0

What are three enzymes associated with hepaticellular injury?

Answer 0

ALT, AST, Sorbitol dehydrogenase

Question 1

Name four functions of the liver

Answer 1

Metabolism of carbs and fats
Synthesis of albumin, clotting factors
Secretion bilirubin
Metabolism and elimination of toxins

Question 2

What is ALT specific in?

Answer 2

Dogs and cats

Question 3

What is ALT not specific in?

Answer 3

Horses cattle pigs

Question 4

What can also cause an increase in ALT?

Answer 4

Glucocorticoids and anticonvulsants

Question 5

Which enzyme is not liver specific but is used when looking for liver disease?

Answer 5

AST

Question 6

When are increased levels of AST often seen?

Answer 6

Muscle inflammation, hemolysis of blood sample

Question 7

What is AST testing used for in the liver?

Answer 7

Ruling out other problems

Question 8

What is sorbitol dehydrogenase liver specific in?

Answer 8

All animals

Question 9

Which liver specific enzyme is not routinely measured?

Answer 9

Sorbitol dehydrogenase

Question 10

What enzymes are associated with obstruction of bile flow? 2

Answer 10

Alkaline phosphate and gamma glutamyltranspeptidase

Question 11

Is alk phos liver specific?

Answer 11

No

Question 12

What is alk phos useful in?

Answer 12

Dogs and cats

Question 13

What is alk phos not useful in?

Answer 13

Horses and cattle

Question 14

This is the first thing to rise in cushiness

Answer 14

Alk phos

Question 15

When will you often see a rise in alk phos? 4

Answer 15

Bone injury, rapidly growing animals, use of glucocorticoids and anti convulsants

Question 16

This enzyme lives in the liver which is its primary source for all animals

Answer 16

GGT

Question 17

What can GGT be increased by?

Answer 17

Glucocorticostwroids and anti convulsants

Question 18

What does bilirubin come from?

Answer 18

From hemoglobin that has been released from lysed RBCs

Question 19

What can cause increased bilirubin? 2

Answer 19

Increased rRBC destruction or liver disease

Question 20

What can lead to a false elevated readings of bilirubin?

Answer 20

Lipemia or hemolysis

Question 21

What are bile acids?

Answer 21

Secreted in bile to promote digestion and absorption of fat from the small intestine

Question 22

What happens to the bile acids?

Answer 22

Reabsorbed from the SI and removed by the liver

Question 23

What can increase bile acids?

Answer 23

Portosystemic shunts, chronic liver disease