Block 34 Week 6 Flashcards
signs and symptoms of anemia?
- General fatigue
- Weakness
- Dyspnea on exertion
- Pallor
vegan diet?
B12 def - can only be obtained from animal sources
alcoholism?
B9 (folate) def
autoimmune conditions?
- autoimmune conditions like lupus or lymphoma can predispose to autoimmune hemolytic anemia
features that would indicate IDA caused by bleeding?
- melena, epistaxis, hematochezia, hematemesis, or menorrhagia indicates bleeding.
features indicating haemolysis?
- Jaundice and dark urine, in the absence of liver disease, suggest hemolysis.
Diffuse severe bone or chest pain may suggest?
sickle cell disease,
stocking-glove parasthesia?
may suggestvitamin B12 deficiency.
jaundice may suggest
acute bleeding
splenomegaly?
may occur with hemolysis, a hemoglobinopathy, connective tissue diseases, myeloproliferative disorders, infection, or cancer.
peripheral neuropathy suggests
B12 def
fever and murmus may suggest
infective endo
what are the microcytic anaemias?
- altered heme or globin synthesis
- iron deficiency
- thalassemia
- sideroblastic anemia
- lead poisoning
- anemia of CD - MCV is microcytic or borderline microcytic - but more commonly a normocytic anemia
what are the megaloblastic macrocytic anaemias?
- impaired DNA synthesis - B12, B9 deficiency,
- methotrexate
what are the normoblastic macrocyctic anaemias?
- alcohol use disorders
- chemo drugs like hydroxyurea or antifolate
- hypothyoridism
- liver disease
- pregnancy
what are the normocytic anaemuas?
- deficiency in EPO or inadequate resp to it
- haemorrhage
- anemia of CD
- CKD
- aplastic anemia
- acute blood loss
- haemolytic anemia
reticulocyte count?
- higher values indicate excessive production (reticulocytosis); in the presence of anemia, reticulocytosis suggests excessive RBC destruction.
- Low numbers in the presence of anemia indicate decreased RBC production.
general symptoms of anaemia?
- Dyspnoea
- Fatigue
- Headache
- Dizziness
- Syncope
- Confusion
- Palpitations
- Angina
underlying causes of anaemia - table
Signs of anaemia
- Bounding pulse
- Postural hypotension
- Tachycardia
- Conjunctival pallor
- shock
mneumonic for microcytic anaemia
- Fe
- thalassemia
- sideroblastic anemia
- chronic disease
IDA signs?
- Atrophic glossitis
- Angular Stomatitis
- Koilonychia
- Pica – craving non-food substances such as ice or dirt
- Restless leg syndrome
- Rarely, tachycardia and signs of heart failure
sideroblastic anaemia?
- group of disorders characterised by dysfunctional haemoglobin synthesis in the mitochondria.
- This leads to the formation of ring sideroblasts in the cytoplasm and microcytic cells secondary to the disease pathogenesis.
deficiency?
causes of sideroblactic anaemia?
- Causes include genetic enzyme deficiency, and environmental causes: vitamin B6 deficiency, lead poisoning and chronic alcoholism.