Block 32 Pharm Flashcards
Antacids and alginates examples
- Magnesium trisilicate
- Aluminium/magnesium mixtures (Maalox) - Alginates
what are antacids and alginates used for?
dyspepsia, GORD
Mag trisillicate mechanism?
-antacid
- inc pH of gastric juicr via neutrilisation
CI of magnesium triscillicate?
Hypophosphataemia
mag tricillicate interactions?
- amlodepine
- nifedipine
- verapamil
mag trisillicate side effects?
- diarrhoea
- nephrolithiasis (long term use)
Co-magaldrox (Maalox) mechanism?
- mix of mag hydroxide and al hydroxide
- neutralises acid
Co-magaldrox indications?
dyspepsia
Co-magaldrox side effects?
constipation and diarrhoea
Co-magaldrox and renal impairment?
There is a risk of accumulation and aluminium toxicity with antacids containing aluminium salts
alginates mechanism?
- reacts w gastric acid to form a raft of alginic acid gel
- raft had a neutral pH
- acts as a barrier to impede reflux
CI of alginic acid?
- intestinal obstruction
- where excessive water loss likely (e.g. fever, diarrhoea, vomiting, high room temperature)
alginates and renal impairment?
avoid - risk of hypernatremia
alginic acid (gaviscon) side effects?
- ankle swelling
- constipation
H2-receptor antagonists?
rantidine
rantidine indications?
dyspepsia, GORD, peptic ulceration, prophylaxis of NSAID associated peptic ulceration
cautions with H2 receptor antagonits like ranitidine?
signs and symptoms of gastric cancer can be masked
ranitidine side effects?
- bone marrow depression
- nephritis
- acute pancreatitis
- dyskinesia
ranitidine mechanism?
- normally after a meal, gastrin -> histamine release -> H2 activation -> acid secretopm
- ranitidine blocks H2 receptors on gastric parietal cells -> less acid produced
PPIs?
- Lansoprazole
- Omeprazole
PPIs mechanism?
- inhition of the H+/K+/ATPase pump
- inhibition of acid production
PPIs and H pylori eradication?
- PUD associated w H pylori infection
- acid inhibition in H pylori eradication therapy raises gastric pH discouraging growth of H pylori
- PPI inhibit urease enzyme
PPIs indications?
- dyspepsia
- GORD
- oesophagitis
- peptic ulceration
- prophylaxis of NSAID associated peptic ulceration
- H. pylori eradication
cautions of PPIs?
- risk of fractures - high doses in the elderly
- C diff infection risk
- masking gastric cancer symptoms
- B12 abs reduced w long term use
- osteoporosis risk