biosafety of clinical research Flashcards
what is woolsorters’ disease now known as
anthrax
what was the cause of laboratory acquired infections LAI in the mid 20th century
mouth pipetting
what lead to the formation of the Advisory committee on dangerous pathogens ADCP
when a woman contracted smallpox from a university in Birmingham
what does the health and safety at work act etc. 1974 means
brought the whole of health safety under one act instead of multiple
what is COSH registration
control of substances hazardous to health, chemicals and biological agents you must take a risk assessment
what is SAPO leglistration
control and containment of specified animal pathogens, prevents animals from serious disease
what do containment labs do
- control areosols
- waste inactivation
- negative pressure environment
- ability to fumigate
- effluent disinfection
what are biological agents classified on
severity of disease
risk to workers
likelihood of community transmission
availability of vaccines or effective treatment
what does containment level 1 mean
unlikely to cause human disease
what does containment level 4 mean
can cause severe human disease, likely to spread to the community, usually no effective prophylaxis
what are the routes of infection
inhalation
inoculation
absorption
ingestion
what is the function of microbiological safety cabinets MSCs
minimise or prevent aerosols
what is the most common MSCs for primary containment
class II
what MSC is best way of controlling infectious aerosols
class II
what protection does Class II MSC provide
operator and sample
