biosafety Flashcards
what is involved in risk group classification
the threat they pose to lab workers and the community at large
how is the potential risk of each agent determined
pathogenicity (ability to cause disease), infection rate after exposure, virulence (severity of disease), stability, and treatment available for said disease
how many risk group levels are there
4
individual and community risk for RG1
low
low
explain why risk is low for RG1
agents are unlikely to cause disease in a healthy person
containment required for RG1?
no special containment needed, work can be done on an open bench, follow microbio procedures, lockable door to room
individual and community risk for RG2
medium
low
explain why there is low and medium risk for RG2
diseases are usually treatable or there are vaccines, not likely to spread in the environment
containment for Rg2?
level 1 requirements + biohazard signs posted, autoclave available, emergency eyewash and shower
individual and community risk for RG3
high
low
explain why there is high and low risk for RG3
agents cause serious harm in humans and animals, but they do not spread between individuals
containment for RG3?
level 1 and 2 requirements + controlled lab access, physical containment for all manipulations, negative airflow into lab, self-closing double door system
individual and community risk for RG4
high
high
why is risk high for RG4
agents cause very serious disease, are often untreatable, may be readily transmitted
containment for RG4?
1+2+3 requirements, isolated lab, dedicated air supply + decontamination systems, change clothes before entering, shower upon exit, all material decontaminated upon exit, procedures done in class 3 or in class 1/2 is full body protection is worn
