Bioenergetics and Regulation of Metabolism Flashcards

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1
Q

Liver:

A

The most metabolically diverse tissue. Hepatocytes are
responsible for the maintenance of blood glucose levels
by glycogenolysis and gluconeogenesis in response to
pancreatic hormone stimulation. The liver also processes
lipids and cholesterol, bile, urea, and toxins.

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2
Q

Adipose Tissue

A

Stores lipids under the influence of insulin and releases
them under the influence of epinephrine

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3
Q

Skeletal Muscle : also what is
Resting Muscle and Active Muscle

A

Skeletal muscle metabolism will differ depending on
current activity level and fiber type.
Resting muscle: Conserves carbohydrates in glycogen
stores and uses free fatty acids from the bloodstream.
Active muscle: May use anaerobic metabolism, oxidative
phosphorylation of glucose, direct phosphorylation from
creatine phosphate, or fatty acid oxidation, depending on
fiber type and exercise duration.

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4
Q

Cardiac Muscle:

A

Uses fatty acid oxidation in both the well-fed and fasting states.

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5
Q

Brain and
Nervous Tissue:

A

Consume only glucose in all metabolic states, except for
prolonged fasts, where up to 2/3 of the brain’s fuel may
come from ketone bodies.

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6
Q

Calorimetry:

A

Measures metabolic rates

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7
Q

Respiratory Quotient:

A

RQ. Estimates the composition of fuel that is actively consumed by the body. RQ = Co2 produced / O2 consumed

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8
Q

Regulatory Hormones:

function of Ghrelin

A

increase appetite. (sight, sound, taste, smell of food)

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9
Q

Regulatory Hormones:

function Orexin

A

increase appetite

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10
Q

Regulatory Hormones:

function Letin

A

decrease appetite by suppressing orexin production

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11
Q

Body Mass Index

A

BMI = mass/ Height^2

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12
Q

Equilibrium:

A

Equilibrium is an undesirable state for most biochemical reactions because organisms need to harness free energy to survive

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13
Q

Postprandial State:

A

Well-fed, absorptive. Increase ­Insulin. Anabolism prevails.

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14
Q

Postabsorptive State

A

Fasting decrease .Insulin. increase ­glucagon and catecholamine. Transition to catabolism

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15
Q

Prolonged Fasting:

A

Starvation increases glucagon and catecholamine. Most tissues rely on fatty acids. 2/3 of brain activity can be derived from ketone bodies.

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16
Q

High Energy

A

May be soluble or membrane-bound. Includes NADH

17
Q

Electron Carriers

A

NADPH, FADH2, ubiquinone, cytochromes, and glutathione.

18
Q

Flavoproteins

A

A subclass of electron carriers that are derived from riboflavin (vitamin B2). Examples: FAD and FMN

19
Q

what is the role of ATP

A

ATP is a mid-level energy molecule. It contains high-energy phosphate bonds that are stabilized upon hydrolysis by resonance, ionization, and loss of charge repulsion

20
Q

Energy Source:

A

ATP provides energy through hydrolysis and coupling to energetically unfavorable reactions. ATP = 30 kl/mol

21
Q

Phosphoryl

A

ATP can donate a phosphate group to other molecules.

22
Q

Group Transfers:

A

For example, in Glycolysis, it donates a Phosphate group to glucose to form glucose 6-phosphate

23
Q

Open System:

A

Matter & energy can be exchanged with the environment

24
Q

Closed System:

A

Only energy can be exchanged with the environment. No work is performed because pressure and volume remain constant. ∆enthalpy = ∆internal energy = heat exchange

25
Q

Entropy

A

A measure of energy dispersion in a system

26
Q

Change in Free Energy:

define Standard Free Energy

A

Standard Free Energy, DeltaG°: The energy change that occurs at 1 M concentration, 1 atm, and 25°C.

27
Q

Change in free Energy define Modified Standard State

A

Modified Standard State, DeltaG°’: Indicates physiological conditions. [H=] = 10^-7, so pH is 7.

28
Q

Define Insulin:

A

Secreted by pancreatic b-cells, regulated by glucose decrease¯blood glucose by increasing cellular uptake increase ­rate of anabolic metabolism

29
Q

Glucagon:

A

Secreted by pancreatic a-cells, stimulated by low glucose and high amino acid levels increses ­blood glucose by promoting gluconeogenesis and glycogenolysis in the liver

30
Q

Glucocorticoids:

A

Increase ­blood glucose in response to stress by mobilizing fat stores and inhibiting glucose uptake. They increase the impact of glucagon and catecholamines. Ex: cortisol

31
Q

Catecholamines:

A

Promote glycogenolysis and increase ­basal metabolic rate through sympathetic nervous system activity. “Adrenaline rush”. Ex: epinephrine and norepinephrine

32
Q

Thyroid Hormones

A

Increase ­basal metabolic rate, as evidenced by ­ Increase O2 consumption and heat production when they are secreted. T3 is more potent than T4, but has a shorter half-life and is available in lower concentrations in the blood. T4 is converted to T3 at the tissues. Thyroid hormones are tyrosine-based

33
Q

Liver definition

A

The most metabolically diverse tissue. Hepatocytes are responsible for the maintenance of blood glucose levels by glycogenolysis and gluconeogenesis in response to pancreatic hormone stimulation. The liver also processes lipids and cholesterol, bile, urea, and toxins

34
Q

Adipose Tissue:

A

Stores lipids under the influence of insulin and releases them under the influence of epinephrine

35
Q

Skeletal Muscle

define

Resting Muscle

A

Conserves carbohydrates in glycogen stores and uses free fatty acids from the bloodstream

36
Q

Skeletal Muscle

define Active muscle

A

May use anaerobic metabolism, oxidative phosphorylation of glucose, direct phosphorylation from creatine phosphate, or fatty acid oxidation, depending on fiber type and exercise duration.

37
Q

cardiac Muscle:

A

Uses fatty acid oxidation in both the well-fed and fasting states.