bcm25 zymogens

Question 1

zymogens

Answer 1

digestive enzymes secreted as inactive precursor zymogens

Question 2

chymotrypsinogen

Answer 2

zymogen to digestive enzyme chymotrypsin

Question 3

where is chymotrypin found?

Answer 3

pancreas

Question 4

why must chymotrypsinogen be in zymogen form?

Answer 4

until it reaches digestive tract to prevent damage

Question 5

why does zymogen have low activity?

Answer 5

due to distorted active site

Question 6

what is chymotrypsin

Answer 6

a protease

Question 7

what is chymotrypsins active site

Answer 7

a catalytic triad

Question 8

why is chymotrypsin zymogen activated by

Answer 8

trypsin

Question 9

what are proteases activated by and where

Answer 9

zymogen cascade in duodenum - 1st section of small intestine

Question 10

trypsingogen -> trypsin

Answer 10

enteropeptidase

cleaves n terminus of trypsin

Question 11

chymotrypsinogen-> chymotrypsin

Answer 11

trypsin

Question 12

how does trypsin activate chymotrypsin

Answer 12

by cleaving out ser asn and arginine so isoleucine swings into active site = increase activity

Question 13

what does trypsin to do trypsinogen?

Answer 13

cleaves out tap = trypsin activation protein to activate trypsin