B8 L3

Question 1

Hypothalamic-Pituitary-Thyroid Axis

HPT Axis

Answer 1

produce thyroid hormone

T3/T4

Question 2

HPT Process

Answer 2

Hypothalamus release TRH (thyotropin)
Ant Pit release TSH
Thyroid releases T3/T4

Question 3

T4 aka….

Answer 3

Thyroxine

Question 4

HPT Feedback

Answer 4

T3/T4 inhibit TSH and TRH

TSH inhibits TRH

Question 5

T3/T4 Function

Answer 5

bone growth
CNS maturation
heat production
increase body metabolism
increase cardiac output

Question 6

Follicular Epithelial Cells

Answer 6

make TH

basal faces blood, apical faces colloid

Question 7

Colloid

Answer 7

mix of TH attached to thyroglobulin

Question 8

Thyroglobulin

Answer 8

protein that binds iodine and helps form thyroid hormone

Question 9

TH Synthesis

Answer 9

requires iodine- added to tyrosine

Question 10

T3 or T4 is more potent?

Answer 10

T3

Question 11

Albumin

Answer 11

binds T3/T4 and carries it through the blood

Question 12

Iodinase

Answer 12

converts T4 to T3 in tissues

Question 13

Hyperthyroidism

Answer 13

too much T3/T4

weight loss, heat intolerance, sweating, increased cardiac output, exopthalamos, goiter

Question 14

Examples of Hyperthyroidism

Answer 14

Grave’s Disease
Thyroid tumor
TSH/ TRH secreting tumor

Question 15

Treating Hyperthyroidism

Answer 15

remove thyroid/ tumor

Question 16

Hypothyroidism

Answer 16

not enough T3/T4

weight gain, cold intolerance, low cardiac output, mental slowness, low energy, myxedema (swollen puffy skin)

Question 17

Examples of Hypothyroidism

Answer 17

Hashimoto’s Disease
Iodine Deficiency
Congenital

Question 18

Treatment of Hypothyroidism

Answer 18

exogenous T3/T4

Question 19

Goiter

Answer 19

from high TSH levels

Question 20

Conditions not yielding a goiter

Answer 20

Hashimoto’s

Congenital