B7 L7 Flashcards
Boyle’s Law
Volume and pressure are inversely related
Contraction of Inspiratory MM
lungs expand
alveolar pressure decreases
air flows in
Relaxation of Inspiratory MM
lungs recoil to original size
increases alveolar pressure
air expelled
Compliance
change in volume per change in pressure
inversely related to elastance
Equilibrium Point
where forces are equal and opposite
chest wall expansion balanced by lung collapsing
equal to FRC- no energy required to maintain volume
Emphysema
loss of elastic fibers
compliance increased
harder to get air out
FRC increased
Fibrosis
lungs lose compliance
greater collapsing force
harder to get air in
FRC reduced
Surfactant
reduces surface tension
keeps lungs open
makes inspiration easier
CO2 is always….
perfusion limited and diffusion limited
more permeable than O2
low gradient
O2 is usually…
perfusion limited
can be diffusion limited in exercise
less permeable than CO2
high gradient
High A-a gradient
something wrong with oxygen exchange
A-a gradient
diff b/t arterial O2 conc and alveolar O2
Fibrotic Diseases
increase distance between air and blood
reduces diffusion
Physiologic Shunts
perfused alveoli with no ventilation
allows deoxygenated blood to enter arterial circulation